2-Methylaziridine
Also known as Propyleneimine, Propylenimine, Aziridine, 2-methyl-
Key facts
What buyers check first
- Appearance
- Colorless, oily liquid
- Melting point
- -65 °C
- Boiling point
- 67 °C
- Density
- Relative density (water = 1): 0.8
- Flash point
- -3.9 °C
- HS code
- 293399
- Category
- Pharmaceutical intermediates
- UN number
- UN 1921

What is 2-Methylaziridine?
Plain description, key identifiers and synonyms
2-Methylaziridine is a member of aziridines.
Identifiers
Registry numbers, names and line notations, tap to copy
- IUPAC name
- 2-methylaziridine
- CAS number
- 75-55-8 CAS number cross-checked
- EC number
- 200-878-7
- Molecular formula
- C3H7N
- UNII
- ULC972Q7TZ
- MDL number
- MFCD00005118
- InChIKey
- OZDGMOYKSFPLSE-UHFFFAOYSA-N
- InChI
- InChI=1S/C3H7N/c1-3-2-4-3/h3-4H,2H2,1H3
- SMILES (canonical and isomeric)
- CC1CN1
Synonyms
- Propyleneimine
- Propylenimine
- Aziridine, 2-methyl-
- Methylaziridine
- 1,2-Propylenimine
- 2-Methylethylenimine
- Methylethylenimine
- Propylene imine
- 1,2-Propyleneimine
- 2-Methylazacyclopropane
- Propilenimina
- RCRA waste number P067
- DL-2-Methylaziridine
- 2-methylethyleneimine
- Propylene imine (inhibited)
- 2-Methyl aziridine
- Propyleneimine, inhibited
- RCRA waste no. P067
- 2-methylaziridine (propylenimine)
- 2-methyl-aziridine
- 5-20-01-00150 (Beilstein Handbook Reference)
- UN 1921 (Salt/Mix)
- Ozdgmoyksfplse-uhfffaoysa-
- 2-?Methylaziridine (Propylenimine)
- 2-Methylaziridine, (+/-)-
Show all 27 synonymsShow fewer synonyms
- 2-Methylaziridine, technical grade, 90%
- Propyleneimine, inhibited [UN1921] [Flammable liquid]
Physical and chemical properties
Measured values and descriptors computed from the structure
Physical and chemical properties
Measured values, check the supplier specification for your grade
| Appearance | Colorless, oily liquidexp.Measured value |
|---|---|
| Odour | Odor like aliphatic aminesexp.Measured value |
| Melting point | -65 °Cexp.Measured value |
| Boiling point | 67 °Cexp.Measured value |
| Density | Relative density (water = 1): 0.8exp.Measured value |
| Flash point | -3.9 °Cexp.Measured value |
| Solubility | In water, miscible in all proportionsexp.Measured value |
| Vapour pressure | 140 mm Hg at 25 °Cexp.Measured value |
Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.
Computed descriptors
Calculated from the structure, useful for screening and formulation
| Molecular weight | 57.10 g/molcalc.Computed value |
|---|---|
| Exact mass | 57.0578 Dacalc.Computed value |
| LogP (octanol/water) | -0.02calc.Computed value |
| Topological polar surface area | 21.94 Ųcalc.Computed value |
| Hydrogen bond donors | 1calc.Computed value |
| Hydrogen bond acceptors | 1calc.Computed value |
| Rotatable bonds | 0calc.Computed value |
| Heavy atoms | 4calc.Computed value |
| Rings | 1calc.Computed value |
| Aromatic rings | 0calc.Computed value |
| Fraction sp3 carbons | 1calc.Computed value |
| Formal charge | 0calc.Computed value |
| Stereocentres | 1calc.Computed value |
| Lipinski rule of five | Passes (0 violations)calc.Computed value |
Calculated for screening. Confirm critical figures with the supplier.
Murcko scaffold
The ring system that remains when every side chain is removed
Safety and hazards
GHS classification summary, not a safety data sheet
Hazard statements
- H225Highly flammable liquid and vapour.
- H300Fatal if swallowed.
- H310Fatal in contact with skin.
- H318Causes serious eye damage.
- H330Fatal if inhaled.
- H350May cause cancer.
- H411Toxic to aquatic life with long lasting effects.
Precautionary statements (34)
- P203Obtain, read and follow all safety instructions before use.
- P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
- P233Keep container tightly closed.
- P240Ground and bond container and receiving equipment.
- P241Use explosion-proof electrical, ventilating and lighting equipment.
- P242Use non-sparking tools.
- P243Take action to prevent static discharges.
- P260Do not breathe dust, fume, gas, mist, vapours or spray.
- P262Do not get in eyes, on skin, or on clothing.
- P264Wash skin thoroughly after handling.
- P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
- P270Do not eat, drink or smoke when using this product.
- P271Use only outdoors or in a well-ventilated area.
- P273Avoid release to the environment.
- P280Wear protective gloves, protective clothing, eye protection and face protection.
- P284In case of inadequate ventilation wear respiratory protection.
- P301 + P316If swallowed: Get emergency medical help immediately.
- P302 + P352If on skin: Wash with plenty of water.
- P303 + P361 + P353If on skin (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower.
- P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
- P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P316Get emergency medical help immediately.
- P317Get medical help.
- P318If exposed or concerned, get medical advice.
- P320Specific treatment is urgent (see supplemental first aid instructions on the label).
- P321Specific treatment (see supplemental first aid instructions on the label).
- P330Rinse mouth.
- P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
- P370 + P378In case of fire: Use appropriate media to extinguish.
- P391Collect spillage.
- P403 + P233Store in a well-ventilated place. Keep container tightly closed.
- P403 + P235Store in a well-ventilated place. Keep cool.
- P405Store locked up.
- P501Dispose of contents and container in accordance with local regulations.
- UN number
- UN 1921
- Transport hazard class
- 3
- Packing group
- I
GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.
Full safety data and first aid2-Methylaziridine suppliers
Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings
- ChinaUnclaimed profile2-MethylaziridineGrade, purity and minimum order on requestPrice on request
- United States, Port Washington ManufacturerUnclaimed profile2-MethylaziridineGrade, purity and minimum order on requestPrice on request
- United States, Pasadena ManufacturerUnclaimed profile2-MethylaziridineGrade, purity and minimum order on requestPrice on request
- United States, Pasadena ManufacturerUnclaimed profile2-MethylaziridineGrade, purity and minimum order on requestPrice on request
- JapanUnclaimed profile2-MethylaziridineGrade, purity and minimum order on requestPrice on request
- China, WuhanUnclaimed profilePropyleneimineGrade, purity and minimum order on requestPrice on request
Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.
Where suppliers are based
6 suppliers in 3 countries
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2-Methylaziridine price
Indicative price range per kg from live supplier offers
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Uses and applications
What the substance is used for, by industry and function
Propyleneimine is used as a chemical intermediate in the manufacture of a variety of paper, textile, rubber, and pharmaceutical chemicals. It is also employed in the production of latex surface-coating resins to improve adhesion.
Organic intermediate whose derivatives are used in the paper, textile, rubber, and pharmaceutical industries.
2-Methylaziridine is used in the United States exclusively as a chemical intermediate, and its derivatives are used in the paper, textile, rubber, and pharmaceutical industries. Because it easily forms imines, its primary use is in the modification of latex surface-coating resins to improve adhesion. Because of the substantive bonding of imines to cellulose derivatives, polymers modified with 2-methylaziridine or its derivatives have been used in the adhesive, textile, and paper industries.
Read more
2-Methylaziridine has been used to modify dyes for specific adhesion to cellulose, and derivatives have been used in photography, gelatins, and synthetic resins. In the oil-additive industry, 2-methylaziridine and its derivatives have been used as modifiers for viscosity control, high-pressure performance, and oxidation resistance. Other applications include use in flocculants in petroleum refining, as a modifier for rocket propellant fuels, in fiber modification, and in imine derivatives for use in medicinal and agricultural chemicals.
1,2-Propyleneimine is used as an intermediate in the paper, textile, rubber, and pharmaceutical industries. Its main use is to improve the adhesion of latex surface-coating resins.
Industrial uses: Intermediate.
Pharmacology
Propylenimine is a synthetic, flammable, volatile, colorless oily liquid that is soluble in water, ethanol and most organic solvents. Propylenimine is used in the United States exclusively as an intermediate, and its derivatives are used in the paper, textile, rubber and pharmaceutical industries. Due to its volatility, potential exposure could occur during production, packaging, or use of substances made with this liquid. The primary routes of potential human exposure to propylenimine are inhalation, ingestion and dermal contact. It is reasonably anticipated to be a human carcinogen. (NCI05)
How it is made
2-Methylaziridine can be prepared by addition of hydrogen chloride to 1-amino-2-propanol to form 2-chloropropylamine hydrochloride which is then treated with sodium hydroxide. It is manufactured commercially by combining 1,2-dichloropropane with ammonia at elevated temperatures.
Regulatory status
Inventories, regulations and trade controls that list this substance
Europe
- EU harmonised classification (CLP Annex VI)Index no: 613-033-00-6
Health and food
- EU Cosmetics Regulation Annex II, prohibited in cosmeticsName: 2-Methylaziridine (propyleneimine), Ref no: 730, Annex ref: II/730
United States
- TSCA inventory (USA)Status: Active in US commerce
HS code and trade data
Customs classification and reported world trade statistics
Global trade
World import and export statistics for the HS code 2-Methylaziridine is traded under.
Heterocyclic compounds with nitrogen hetero-atom(s) only, other
- Slovenia31.7%
- Italy24.2%
- United States5.0%
* Partner reported figures, a lower bound.
The HS code shown for 2-Methylaziridine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.
Frequently asked questions
Quick answers about 2-Methylaziridine, based on the data on this page
What is 2-Methylaziridine?
What is the CAS number of 2-Methylaziridine?
What is the molecular formula and weight of 2-Methylaziridine?
What is 2-Methylaziridine used for?
Is 2-Methylaziridine hazardous?
What is the HS code of 2-Methylaziridine?
Where can I buy 2-Methylaziridine?
What is the price of 2-Methylaziridine?
Guides for buyers
Practical guides that help when you source, ship or handle 2-Methylaziridine
- Article, QualityPharma grades explained: IP vs BP vs USP vs EPWhat the Indian, British, US and European pharmacopoeias are, how their monographs differ, what multi grade claims mean and why a grade alone does not make a product fit for medicines.Read
- Guide, SafetyHow to read a safety data sheet in 10 minutesA section by section method to pull the essentials out of any 16 section SDS: identity, hazards, composition, storage, PPE, properties, transport and emergency measures.Read
- Guide, Trade and logisticsShipping dangerous goods: UN numbers, classes and packing groupsHow the UN dangerous goods system works for chemicals, from the nine classes and UN numbers to packing groups, UN packaging marks, labels, documents and segregation.Read
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