Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 1 to 60 of 15,838 scaffolds
![Scaffold c1ccc2[nH]ccc2c1](/scaffold/SIKJAQJRHWYJAI-UHFFFAOYSA-N/structure.svg)
Indole2,455 chemicals, 2 rings
Quinoline2,226 chemicals, 2 rings
Benzanilide1,973 chemicals, 2 rings
Naphthalene1,898 chemicals, 2 rings
Biphenyl1,627 chemicals, 2 rings![Scaffold c1ccc2[nH]cnc2c1](/scaffold/HYZJCKYKOHLVJF-UHFFFAOYSA-N/structure.svg)
Benzimidazole1,206 chemicals, 2 rings
Benzenesulfonanilide978 chemicals, 2 rings
Diphenylmethane952 chemicals, 2 rings
1-Phenylpyrazole937 chemicals, 2 rings
Diphenyl ether933 chemicals, 2 rings
Benzyl phenyl ether829 chemicals, 2 rings![Scaffold c1ccc2[nH]ncc2c1](/scaffold/BAXOFTOLAUCFNW-UHFFFAOYSA-N/structure.svg)
1H-Indazole795 chemicals, 2 rings
1,3,2-Dioxaborolane, 2-phenyl-795 chemicals, 2 rings
Cyclopropylbenzene778 chemicals, 2 rings
Benzothiazole756 chemicals, 2 rings
Fluorene647 chemicals, 3 rings
Flavone646 chemicals, 3 rings
Benzofuran632 chemicals, 2 rings
Indane621 chemicals, 2 rings
Coumarin614 chemicals, 2 rings
1,2,3,4-Tetrahydroisoquinoline607 chemicals, 2 rings
1-Phenylpiperazine595 chemicals, 2 rings
Isoquinoline569 chemicals, 2 rings
Benzophenone537 chemicals, 2 rings
1,3-Benzodioxole536 chemicals, 2 rings
Benzo(B)thiophene529 chemicals, 2 rings
Imidazo(1,2-a)pyridine525 chemicals, 2 rings
Phenoxyacetanilide476 chemicals, 2 rings
c1ncc2ncn(C3CCCO3)c2n1474 chemicals, 3 rings![Scaffold S=c1[nH]nc(-c2ccccc2)n1N=Cc1ccccc1](/scaffold/DFCISOWMWAKUDC-UHFFFAOYSA-N/structure.svg)
2,4-Dihydro-5-phenyl-4-[(phenylmethylene)amino]-3H-1,2,4-triazole-3-thione451 chemicals, 3 rings
Indoline440 chemicals, 2 rings
Tetralin432 chemicals, 2 rings
Carbanilide421 chemicals, 2 rings![Scaffold O=c1[nH]c(=O)c2[nH]cnc2[nH]1](/scaffold/LRFVTYWOQMYALW-UHFFFAOYSA-N/structure.svg)
Xanthine411 chemicals, 2 rings
Adamantane402 chemicals, 4 rings
Thiazole, 4-phenyl-400 chemicals, 2 rings
Diphenylamine395 chemicals, 2 rings
O=C(C=Cc1ccccc1)c1ccccc1389 chemicals, 2 rings![Scaffold c1ccc(-c2cc[nH]n2)cc1](/scaffold/OEDUIFSDODUDRK-UHFFFAOYSA-N/structure.svg)
3-Phenyl-1H-pyrazole387 chemicals, 2 rings
1,2,3,4-Tetrahydroquinoline384 chemicals, 2 rings
Azobenzene383 chemicals, 2 rings
N-Benzylideneaniline379 chemicals, 2 rings
Chroman376 chemicals, 2 rings![Scaffold O=c1cc[nH]c2ccccc12](/scaffold/PMZDQRJGMBOQBF-UHFFFAOYSA-N/structure.svg)
4-Hydroxyquinoline373 chemicals, 2 rings![Scaffold O=c1cc[nH]c(=O)[nH]1](/scaffold/ISAKRJDGNUQOIC-UHFFFAOYSA-N/structure.svg)
Uracil366 chemicals, 1 ring![Scaffold O=c1ccc2ccccc2[nH]1](/scaffold/LISFMEBWQUVKPJ-UHFFFAOYSA-N/structure.svg)
2-Hydroxyquinoline365 chemicals, 2 rings
Phthalimide352 chemicals, 2 rings
Dihydrobenzofuran349 chemicals, 2 rings
1,3-Diphenyl-1H-pyrazole341 chemicals, 3 rings
Anthraquinone335 chemicals, 3 rings
1-Phenylpyrrole324 chemicals, 2 rings
2-Phenylfuran323 chemicals, 2 rings
Quinazoline315 chemicals, 2 rings
C1CCC2C(C1)CCC1C3CCCC3CCC21315 chemicals, 4 rings
Bicyclo(2.2.1)heptane310 chemicals, 2 rings
Phenyl benzoate309 chemicals, 2 rings
Benzylaniline309 chemicals, 2 rings![Scaffold O=c1ccn(C2CCCO2)c(=O)[nH]1](/scaffold/CWWIKVUHBBTKHC-UHFFFAOYSA-N/structure.svg)
Tetrahydrofuryluracil305 chemicals, 2 rings
2-Phenylthiazole302 chemicals, 2 rings
O=C1C=C2CCC3C4CCCC4CCC3C2CC1301 chemicals, 4 rings