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Cosmetic antioxidants

3-Hydroxyisovaleric acid

Also known as beta-Hydroxyisovaleric acid, 3-Hydroxy-3-methylbutanoic acid, 3-Hydroxy-3-methylbutyric acid

CAS 625-08-1Formula C5H10O3Molar mass 118.13 g/molEC 626-699-8
GHS signal word: Warning. Pictograms: Harmful or irritant 35 suppliers listed
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3-Hydroxyisovaleric acid chemical structure, C5H10O3, CAS 625-08-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
625-08-1
Formula
C5H10O3
Molar mass
118.13 g/mol
EC number
626-699-8
HS code
291819
Category
Cosmetic antioxidants

What is 3-Hydroxyisovaleric acid?

Plain description, key identifiers and synonyms

3-hydroxyisovaleric acid is a 3-hydroxy monocarboxylic acid that is isovaleric acid substituted at position 3 by a hydroxy group. Used as indicator of biotin deficiency. It has a role as a human metabolite. It is functionally related to an isovaleric acid and a butyric acid. It is a conjugate acid of a 3-hydroxyisovalerate.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
3-hydroxy-3-methylbutanoic acid
CAS number
625-08-1 CAS number cross-checkedOther or deprecated CAS: 123743-99-7
EC number
626-699-8
Molecular formula
C5H10O3
UNII
3F752311CD
MDL number
MFCD00059081
INCI name
3-METHYL-3-HYDROXYBUTYRIC ACID
InChIKey
AXFYFNCPONWUHW-UHFFFAOYSA-N
InChI
InChI=1S/C5H10O3/c1-5(2,8)3-4(6)7/h8H,3H2,1-2H3,(H,6,7)
SMILES (canonical and isomeric)
CC(C)(CC(=O)O)O

Synonyms

  • beta-Hydroxyisovaleric acid
  • 3-Hydroxy-3-methylbutanoic acid
  • 3-Hydroxy-3-methylbutyric acid
  • 3-OH-isovaleric acid
  • 3-hydroxy-3-methyl-butanoic acid
  • 3-hydroxy-isovaleric acid
  • Hmb-d6
  • beta-Hydroxy-methylbutyrate
  • beta-hydroxy-beta-methylbutyric acid
  • beta hydroxy beta methylbutyrate
  • beta-hydroxy beta-methylbutyrate
  • B-hydroxyisovaleric acid
  • Butanoic acid, 3-hydroxy-3-methyl-
  • Juven
  • 3-hydroxy-3-methyl-Butyric acid
  • Butyric acid, 3-hydroxy-3-methyl-
  • 3-hydroxy-3-methyl butyric acid
  • beta-Hydroxyisovaleric Acid-d8
  • Beta-(Hydroxyisovaleric Acid)
  • B-hydroxy-b-methylbutyric acid
  • B-hydroxy
  • 3-methyl-3-hydroxybutyric acid
  • B-hydroxyisovalerate
  • Beta-Hydroxy beta-methylbutyric acid
  • B-hydroxy-b-methylbutyrate
Show all 31 synonyms
  • hydroxy-beta-methylbutyrate
  • 3-hydroxy-3-methyl-Butanoate
  • beta-Hydroxy-isovaleric acid
  • ?-Hydroxyisovaleric acid
  • 3-Hydroxy-3-Methyl butanoic Acid
  • beta-Hydroxyisovaleric acid, >=95.0% (T)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
118.13 g/molcalc.
Exact mass
118.063 Dacalc.
LogP (octanol/water)
0.23calc.
Topological polar surface area
57.53 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
2calc.
Heavy atoms
8calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.8calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

3-Hydroxyisovaleric acid suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 35 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

35 suppliers in 7 countries

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3-Hydroxyisovaleric acid price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name 3-METHYL-3-HYDROXYBUTYRIC ACID(antioxidant)

Roles

  • animal metabolite
  • anti-ulcer drug
  • eukaryotic metabolite
  • human metabolite
  • mammalian metabolite
  • metabolite
  • pharmaceutical

Cosmetic functions

  • Antioxidant

Pharmacology

Juven is an orally bioavailable nutritional supplement. Juven contains the amino acids glutamine and arginine in addition to beta-hydroxy-beta-methylbutyrate (HMB). This agent may promote muscle protein synthesis and increase muscle mass. (NCI04)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code 3-Hydroxyisovaleric acid is traded under.

HS 2918.19Indicative HS code

Carboxylic acids with alcohol function but without other oxygen function, their…

World exports in 2024
$1.37B
+0.5% vs 2023, imports $1.18B
2019 to 2024
Top exporters
  1. China23.7%
  2. Italy14.7%
  3. India * partner reported12.0%
Top importers
  1. Germany11.7%
  2. South Korea9.8%
  3. Italy9.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for 3-Hydroxyisovaleric acid is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about 3-Hydroxyisovaleric acid, based on the data on this page

What is 3-Hydroxyisovaleric acid?

3-hydroxyisovaleric acid is a 3-hydroxy monocarboxylic acid that is isovaleric acid substituted at position 3 by a hydroxy group. Used as indicator of biotin deficiency. It has a role as a human metabolite. It is functionally related to an isovaleric acid and a butyric acid.

What is the CAS number of 3-Hydroxyisovaleric acid?

The CAS registry number of 3-Hydroxyisovaleric acid is 625-08-1. Other or deprecated CAS numbers: 123743-99-7.

What is the molecular formula and weight of 3-Hydroxyisovaleric acid?

The molecular formula of 3-Hydroxyisovaleric acid is C5H10O3 and its molar mass is 118.13 g/mol.

What is 3-Hydroxyisovaleric acid used for?

Known uses and roles of 3-Hydroxyisovaleric acid include antioxidants in cosmetics and personal care, animal metabolite, anti-ulcer drug, eukaryotic metabolite, human metabolite and 4 more.

Is 3-Hydroxyisovaleric acid hazardous?

3-Hydroxyisovaleric acid carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of 3-Hydroxyisovaleric acid?

3-Hydroxyisovaleric acid is usually classified under HS code 291819 (Carboxylic acids with alcohol function but without other oxygen function, their…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy 3-Hydroxyisovaleric acid?

CompoundList lists 35 suppliers of 3-Hydroxyisovaleric acid in China, United States, Germany, France and 3 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of 3-Hydroxyisovaleric acid?

Suppliers quote 3-Hydroxyisovaleric acid on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle 3-Hydroxyisovaleric acid

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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