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Impurities and reference standards

4-Methylpyridine

Also known as 4-Picoline, gamma-Picoline, Pyridine, 4-methyl-

CAS 108-89-4Formula C6H7NMolar mass 93.13 g/molEC 203-626-4
GHS signal word: Danger. Pictograms: Flammable, Acute toxicity (severe) 30 suppliers listed
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4-Methylpyridine chemical structure, C6H7N, CAS 108-89-4
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless liquid
Melting point
3.7 ยฐC
Boiling point
145 ยฐC
Density
0.9548 g/cmยณ at 20 ยฐC
Flash point
57 ยฐC
HS code
293339
Category
Impurities and reference standards
UN number
UN 2313
Illustrative photo, 200 litre blue HDPE drums of liquid in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is 4-Methylpyridine?

Plain description, key identifiers and synonyms

4-methylpyridine is a methylpyridine in which the methyl substituent is at position 4.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-methylpyridine
CAS number
108-89-4 CAS number cross-checkedOther or deprecated CAS: 92075-35-9
EC number
203-626-4
Molecular formula
C6H7N
UNII
TJD6V9SSO7
MDL number
MFCD00006440
InChIKey
FKNQCJSGGFJEIZ-UHFFFAOYSA-N
InChI
InChI=1S/C6H7N/c1-6-2-4-7-5-3-6/h2-5H,1H3
SMILES (canonical and isomeric)
CC1=CC=NC=C1

Synonyms

  • 4-Picoline
  • gamma-Picoline
  • Pyridine, 4-methyl-
  • p-Picoline
  • p-Methylpyridine
  • 4-methyl pyridine
  • gamma-Methylpyridine
  • Ba 35846
  • 4-methyl-pyridine
  • 4-Mepy
  • Picoline, gamma
  • 4-Methyl-d1-pyridine
  • gamma-picolin
  • 4-pi-coline
  • para-Methylpyridine
  • Nicorandil Impurity 1
  • 4-Methylpyridine, 98%
  • 4-Methylpyridine, 99%
  • 4-Picoline, analytical reference material
  • 4-Methyl-pyridine (gamma-picoline)
  • p-Picoline [UN2313] [Flammable liquid]

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless liquidexp.
Odour
Obnoxious, sweetish odorexp.
Melting point
3.7 ยฐCexp.
Boiling point
145 ยฐCexp.
Density
0.9548 g/cmยณ at 20 ยฐCexp.
Flash point
57 ยฐCexp.
Solubility
Miscible with water at 20 ยฐCexp.
Vapour pressure
5.77 mm Hg at 25 ยฐCexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
93.13 g/molcalc.
Exact mass
93.0578 Dacalc.
LogP (octanol/water)
1.39calc.
Topological polar surface area
12.89 ร…ยฒcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
0calc.
Heavy atoms
7calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.17calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccncc1

c1ccncc1

1 ring, 6 atoms, the Pyridine ring system.

118,162 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS02: Flammable
Flammable
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
230NFPA 704 rating

Hazard statements

  • H226Flammable liquid and vapour.
  • H302Harmful if swallowed.
  • H311Toxic in contact with skin.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H332Harmful if inhaled.
  • H335May cause respiratory irritation.
Precautionary statements (32)
  • P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
  • P233Keep container tightly closed.
  • P240Ground and bond container and receiving equipment.
  • P241Use explosion-proof electrical, ventilating and lighting equipment.
  • P242Use non-sparking tools.
  • P243Take action to prevent static discharges.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P303 + P361 + P353If on skin (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P316Get emergency medical help immediately.
  • P317Get medical help.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P370 + P378In case of fire: Use appropriate media to extinguish.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P403 + P235Store in a well-ventilated place. Keep cool.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 2313
Transport hazard class
3
Packing group
III

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

4-Methylpyridine suppliers

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Where suppliers are based

30 suppliers in 8 countries

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4-Methylpyridine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Manufacture of isonicotinic acid and derivatives. In waterproofing agents for fabrics. As solvent for resins.

Solvent in synthesis of pharmaceuticals, resins, dyestuffs, rubber accelerators, pesticides, and waterproofing agents, laboratory reagent, making isoniazid, catalyst, curing agent.

The main use of 4-methylpyridine is in the production of the antituberculosis agent, isoniazid, also used to make 4-vinylpyridine, and subsequently polymers.

Production of indolizinium quaternary salts for trimethine dyes.

Industrial uses: Intermediate.

Functional uses

  • Flavouring and nutrient

How it is made

Acetaldehyde and ammonia give 2-methylpyridine and 4-methylpyridine.

From cyclohexylamine plus ammonia and zinc chloride, also from coal tar and bone oil.

Paraldehyde + ammonia (liquid-phase condensation, coproduced with alpha-picoline/2-methyl-5-ethyl-pyridine)

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 613-037-00-8

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code 4-Methylpyridine is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structureโ€ฆ

World exports in 2024
$9.16B
โˆ’17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for 4-Methylpyridine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about 4-Methylpyridine, based on the data on this page

What is 4-Methylpyridine?

4-methylpyridine is a methylpyridine in which the methyl substituent is at position 4.

What is the CAS number of 4-Methylpyridine?

The CAS registry number of 4-Methylpyridine is 108-89-4. Other or deprecated CAS numbers: 92075-35-9.

What is the molecular formula and weight of 4-Methylpyridine?

The molecular formula of 4-Methylpyridine is C6H7N and its molar mass is 93.13 g/mol.

What is 4-Methylpyridine used for?

Manufacture of isonicotinic acid and derivatives. In waterproofing agents for fabrics. As solvent for resins. Solvent in synthesis of pharmaceuticals, resins, dyestuffs, rubber accelerators, pesticides, and waterproofing agents, laboratory reagent, making isoniazid, catalyst, curing agent.

Is 4-Methylpyridine hazardous?

4-Methylpyridine carries the GHS signal word "Danger". Main hazards: flammable liquid and vapour, harmful if swallowed, toxic in contact with skin. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of 4-Methylpyridine?

4-Methylpyridine is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in theโ€ฆ). This is indicative, confirm it with your customs broker before shipping.

Where can I buy 4-Methylpyridine?

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Where can I buy 4-Methylpyridine in India?

3 suppliers in India list 4-Methylpyridine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of 4-Methylpyridine?

Suppliers quote 4-Methylpyridine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle 4-Methylpyridine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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