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Chlorinated and fluorinated solvents

Acetyl chloride

Also known as Ethanoyl chloride, Acetic chloride, Acetic acid chloride

CAS 75-36-5Formula C2H3ClOMolar mass 78.50 g/molEC 200-865-6
GHS signal word: Danger. Pictograms: Flammable, Corrosive 97 suppliers listed
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Acetyl chloride chemical structure, C2H3ClO, CAS 75-36-5
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Liquid
Melting point
-112.7 °C
Boiling point
51 °C
Density
1.1051g/cm³ at 20 °C
Flash point
5 °C
HS code
291590
Category
Chlorinated and fluorinated solvents
UN number
UN 1717
Illustrative photo, a closed 1000 litre IBC tote in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Acetyl chloride?

Plain description, key identifiers and synonyms

Acetyl chloride is an acyl chloride. It is functionally related to an acetic acid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
acetyl chloride
CAS number
75-36-5 CAS number cross-checked
EC number
200-865-6
Molecular formula
C2H3ClO
UNII
QD15RNO45K
MDL number
MFCD00000719
InChIKey
WETWJCDKMRHUPV-UHFFFAOYSA-N
InChI
InChI=1S/C2H3ClO/c1-2(3)4/h1H3
SMILES (canonical and isomeric)
CC(=O)Cl

Synonyms

  • Ethanoyl chloride
  • Acetic chloride
  • Acetic acid chloride
  • Acetylchloride
  • Acetic acid, chloride
  • CH3COCl
  • RCRA waste number U006
  • CH3-CO-Cl
  • C2H3ClO
  • Acetyl chloride, reagent grade, 98%
  • RCRA waste no. U006
  • acetylchlorid
  • acetylchlorine
  • Acetic Acid Chloride, Acetic Chloride, Ethanoyl Chloride, AcCl
  • acetyl chlorid
  • acetyl chlorine
  • acetyl choride
  • acetyl cloride
  • actyl chloride
  • Acteyl chloride
  • AcCl
  • Ac-Cl
  • methyl carbonyl chloride
  • Acetic acid monochloride
  • Acetic acid,chloride
Show all 32 synonyms
  • 4-02-00-00395 (Beilstein Handbook Reference)
  • UN1717 (DOT)
  • UN 1717
  • Acetyl chloride, for synthesis, 98.0%
  • Acetyl chloride, ReagentPlus(R), >=99%
  • Acetyl chloride [UN1717] [Flammable liquid]
  • Acetyl chloride, puriss. p.a., >=99.0% (T)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Liquidexp.
Odour
Pungent odorexp.
Melting point
-112.7 °Cexp.
Boiling point
51 °Cexp.
Density
1.1051g/cm³ at 20 °Cexp.
Flash point
5 °Cexp.
Autoignition temperature
390 °Cexp.
Solubility
Decomposed violently by water or alcoholexp.
Vapour pressure
287 mm Hg at 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
78.50 g/molcalc.
Exact mass
77.9872 Dacalc.
LogP (octanol/water)
0.77calc.
Topological polar surface area
17.07 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
0calc.
Heavy atoms
4calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.5calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS02: Flammable
Flammable
GHS05: Corrosive
Corrosive
332WNFPA 704 rating

Hazard statements

  • H225Highly flammable liquid and vapour.
  • H314Causes severe skin burns and eye damage.
Precautionary statements (21)
  • P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
  • P233Keep container tightly closed.
  • P240Ground and bond container and receiving equipment.
  • P241Use explosion-proof electrical, ventilating and lighting equipment.
  • P242Use non-sparking tools.
  • P243Take action to prevent static discharges.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P330 + P331If swallowed: Rinse mouth. Do not induce vomiting.
  • P302 + P361 + P354If on skin: Take off immediately all contaminated clothing. Immediately rinse with water for several minutes.
  • P303 + P361 + P353If on skin (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P316Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P363Wash contaminated clothing before reuse.
  • P370 + P378In case of fire: Use appropriate media to extinguish.
  • P403 + P235Store in a well-ventilated place. Keep cool.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 1717
Transport hazard class
3
Packing group
II

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Acetyl chloride suppliers

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All 97 suppliers
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Where suppliers are based

97 suppliers in 15 countries

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Acetyl chloride price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Acetylating agent, in testing for cholesterol, determination of water in organic liquids.

Organic preparations (acetylating agent), dyestuffs, pharmaceuticals.

Acetyl chloride is an efficient acetylating agent for alcohols and amines to produce esters and amides. It is important in the synthesis of dyes and pharmaceuticals. Acetyl chloride is used in the Friedel-Craft acylation of benzene to yield acetophenone.

Acetyl chloride is a powerful acetylating agent. It is used in the manufacture of aspirin, acetaminophen, acetanilide, and acetophenone. Liquid crystal compositions for optical display and memory devices frequently require acetyl chloride.

Industrial uses: Intermediate.

Consumer uses: Intermediate.

How it is made

Prepared from acetic acid and chlorine in the presence of phosphorus, from acetic acid and salts of chlorosulfonic acid, from sodium acetate and sulfuryl chloride. ... Lab preparation from acetic anhydride and calcium chloride.

By mixing glacial acetic acid and phosphorus trichloride in the cold and heating a short time to drive off hydrochloric acid. The acetyl chloride is then distilled.

The normal industrial method involves reaction of acetic anhydride with anhydrous hydrogen chloride. On the laboratory scale, it can be produced from acetic acid and reagents such as thionyl chloride, phosphorus trichloride, or phosphorus pentachloride.

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 607-011-00-5

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Acetyl chloride is traded under.

HS 2915.90Indicative HS code

Saturated acyclic monocarboxylic acids, anhydrides, halides, peroxides, peroxyacids and halogenated…

World exports in 2024
$3.42B
+5.6% vs 2023, imports $3.55B
2019 to 2024
Top exporters
  1. Indonesia15.9%
  2. Germany13.0%
  3. Malaysia12.4%
Top importers
  1. China14.4%
  2. Netherlands11.7%
  3. United States11.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Acetyl chloride is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Acetyl chloride, based on the data on this page

What is Acetyl chloride?

Acetyl chloride is an acyl chloride. It is functionally related to an acetic acid.

What is the CAS number of Acetyl chloride?

The CAS registry number of Acetyl chloride is 75-36-5.

What is the molecular formula and weight of Acetyl chloride?

The molecular formula of Acetyl chloride is C2H3ClO and its molar mass is 78.50 g/mol.

What is Acetyl chloride used for?

Acetylating agent, in testing for cholesterol, determination of water in organic liquids. Organic preparations (acetylating agent), dyestuffs, pharmaceuticals. Acetyl chloride is an efficient acetylating agent for alcohols and amines to produce esters and amides.

Is Acetyl chloride hazardous?

Acetyl chloride carries the GHS signal word "Danger". Main hazards: highly flammable liquid and vapour, causes severe skin burns and eye damage. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Acetyl chloride?

Acetyl chloride is usually classified under HS code 291590 (Saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Acetyl chloride?

CompoundList lists 97 suppliers of Acetyl chloride in India, China, United States, United Kingdom and 11 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Acetyl chloride in India?

32 suppliers in India list Acetyl chloride on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Acetyl chloride?

Suppliers quote Acetyl chloride on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Acetyl chloride

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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