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Antibiotics and anti-infectives

Adefovir

Also known as ((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid, PMEA, 9-(2-Phosphonylmethoxyethyl)adenine

CAS 106941-25-7Formula C8H12N5O4PMolar mass 273.19 g/molEC 600-789-7
GHS signal word: Danger. Pictograms: Acute toxicity (severe) 102 suppliers listed Drug substance
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Adefovir chemical structure, C8H12N5O4P, CAS 106941-25-7
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Off-white crystalline solid
Melting point
>250
Solubility
MW: 501.47. Off-white crystalline powder. Solubility in water (mg/mL): 19 (pH 2.0), 0.4…
HS code
293359
Category
Antibiotics and anti-infectives
Illustrative photo, off-white powder in an open kraft paper sack in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Adefovir?

Plain description, key identifiers and synonyms

Adefovir is a member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-(6-amino-9H-purin-9-yl)ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(t-butoxycarbonyloxymethyl) ester (dipivoxil ester) prodrug is used to treat chronic hepatitis B viral infection. It has a role as an antiviral drug, a drug metabolite, a nephrotoxic agent, a HIV-1 reverse transcriptase inhibitor and a DNA synthesis inhibitor. It is a member of 6-aminopurines, an ether and a member of phosphonic acids. It is functionally related to an adenine. It is a conjugate acid of an adefovir(1-).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-(6-aminopurin-9-yl)ethoxymethylphosphonic acid
CAS number
106941-25-7 CAS number cross-checked
EC number
600-789-7
Molecular formula
C8H12N5O4P
UNII
6GQP90I798
MDL number
MFCD00866943
InChIKey
SUPKOOSCJHTBAH-UHFFFAOYSA-N
InChI
InChI=1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16)
SMILES (canonical and isomeric)
C1=NC(=C2C(=N1)N(C=N2)CCOCP(=O)(O)O)N

Synonyms

  • ((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid
  • PMEA
  • 9-(2-Phosphonylmethoxyethyl)adenine
  • GS 0393
  • 9-(2-(Phosphonomethoxy)ethyl)adenine
  • 2-(6-aminopurin-9-yl)ethoxymethylphosphonic acid
  • GS 393
  • N-(2-Phosphonylmethoxyethyl)adenine
  • {[2-(6-Amino-9h-Purin-9-Yl)ethoxy]methyl}phosphonic Acid
  • 9-(2-phosphonomethoxyethyl)adenine
  • Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]-
  • 9-[2-(phosphonomethoxy)ethyl]adenine
  • Phosphonic acid, ((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)-
  • [[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosphonic Acid
  • 9-[2-phosphonomethoxyethyl]adenine
  • 9-PMEA
  • Adefovirum
  • Phosphonylmethoxyethyl-a
  • (2-(6-amino-9H-purin-9-yl)ethoxy)methylphosphonic acid
  • [2-(6-amino-9H-purin-9-yl)ethoxy]methylphosphonic acid
  • N-(2-Phophonomethoxyethyl-2,6-diaminopurine)
  • adefovir(1-)
  • Adefovir, P-[[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosphonic acid, 9-(2-phosphonylmethoxyethyl)adenine, PMEA, GS-393
  • 106941-25-7 (free acid)
  • Adefovir (USAN/INN)
Show all 27 synonyms
  • AMD3100 and PMEA
  • Adefovir - Bio-X trade mark

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Off-white crystalline solidexp.
Melting point
>250exp.
Solubility
MW: 501.47. Off-white crystalline powder. Solubility in water (mg/mL): 19 (pH 2.0), 0.4 (pH 7.2), log Kow (octanol/aqueous phosphate buffer): 1.91 /Adefovir di(pivaloyloxymethyl) ester/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
273.19 g/molcalc.
Exact mass
273.0627 Dacalc.
LogP (octanol/water)
-0.44calc.
Topological polar surface area
136.4 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
5calc.
Heavy atoms
18calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.38calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ncc2[nH]cnc2n1

c1ncc2[nH]cnc2n1

2 rings, 9 atoms, the Purine ring system.

2,038 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H301Toxic if swallowed.
Precautionary statements (7)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Adefovir suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 102 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

102 suppliers in 14 countries

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Adefovir price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Pharmacological actions

  • Antiviral Agents
  • Reverse Transcriptase Inhibitors

Roles

  • DNA synthesis inhibitor
  • HIV-1 reverse transcriptase inhibitor
  • aetiopathogenetic role
  • animal metabolite
  • anti-HBV agent
  • anti-HIV agent
  • anti-HIV-1 agent
  • antiinfective agent
  • antimicrobial agent
  • antimicrobial drug
  • antiviral agent
  • antiviral drug
  • drug metabolite
  • enzyme inhibitor
  • eukaryotic metabolite
  • human metabolite
  • human xenobiotic metabolite
  • mammalian metabolite
  • metabolite
  • nephrotoxic agent
  • pathway inhibitor
  • pharmaceutical
  • xenobiotic metabolite

Pharmacology

Adefovir is a Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor. The mechanism of action of adefovir is as a Nucleoside Reverse Transcriptase Inhibitor.

How it is made

Preparation: A. Holy, I. Rosenberg, EP 206459, eidem, US 4808716 (1986, 1989 both to Ceskoslov. Akad. Ved)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Adefovir is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Adefovir is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Adefovir, based on the data on this page

What is Adefovir?

Adefovir is a member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-(6-amino-9H-purin-9-yl)ethoxy group.

What is the CAS number of Adefovir?

The CAS registry number of Adefovir is 106941-25-7.

What is the molecular formula and weight of Adefovir?

The molecular formula of Adefovir is C8H12N5O4P and its molar mass is 273.19 g/mol.

What is Adefovir used for?

Known uses and roles of Adefovir include antivirals in pharmaceuticals, dna synthesis inhibitor, hiv-1 reverse transcriptase inhibitor, aetiopathogenetic role, animal metabolite and 21 more.

Is Adefovir hazardous?

Adefovir carries the GHS signal word "Danger". Main hazards: toxic if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Adefovir?

Adefovir is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Adefovir?

CompoundList lists 102 suppliers of Adefovir in China, United States, United Kingdom, Germany and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Adefovir in India?

3 suppliers in India list Adefovir on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Adefovir?

Suppliers quote Adefovir on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Adefovir

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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