Afatinib (CAS 850140-72-6): price, suppliers and safety

What is Afatinib?

Plain description, key identifiers and synonyms

Afatinib is a quinazoline compound having a 3-chloro-4-fluoroanilino group at the 4-position, a 4-dimethylamino-trans-but-2-enamido group at the 6-position, and an (S)-tetrahydrofuran-3-yloxy group at the 7-position. Used (as its dimaleate salt) for the first-line treatment of patients with metastatic non-small cell lung cancer. It has a role as an antineoplastic agent and a tyrosine kinase inhibitor. It is a secondary carboxamide, a member of furans, an aromatic ether, an organofluorine compound, a member of quinazolines, a tertiary amino compound, an enamide and a member of monochlorobenzenes.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name: (E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
CAS number: 850140-72-6 CAS number cross-checkedOther or deprecated CAS: 439081-18-2
EC number: 810-720-4
Molecular formula: C₂₄H₂₅ClFN₅O₃
UNII: 41UD74L59M
MDL number: MFCD12407405, MFCD31630115
InChIKey: ULXXDDBFHOBEHA-CWDCEQMOSA-N
InChI: InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1
Canonical SMILES: CN(C)CC=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OC1CCOC1
Isomeric SMILES: CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4

Synonyms

BIBW2992
Tomtovok
BIBW 2992
BIBW-2992
afatinibum
(2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-oxolan-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide
(2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide
(2E)-N-(4-(3-chloro-4-fluoroanilino)-7-(((3S)-oxolan-3-yl)oxy)quinoxazolin-6-yl)-4-(dimethylamino)but-2-enamide
(2E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((3S)-oxolan-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
(2E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((3S)-tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
2-Butenamide, N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((3S)-tetrahydro-3-furanyl)oxy)-6-quinazolinyl)-4-(dimethylamino)-, (2E)-
Tovok
(E/Z)-Afatinib
(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Afatinib (BIBW2992)
Afatinib free base
Afatinib, Free Base
BIBW2992 (Tovok)
(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
C24H25ClFN5O3
N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-Butenamide
(E)-N-[4-(3-chloro-4-fluoro-anilino)-7-[(3S)-tetrahydrofuran-3-yl]oxy-quinazolin-6-yl]-4-(dimethylamino)but-2-enamide
(S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
850140-72-6 (free base)
(S,E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

Show all 34 synonyms

(E/Z)-BIBW 2992
Afatinib E-Isomer
(S)-Afatinib
(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide
(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide, BIBW 2992,
(E)-4-dimethylamino-but-2-enoic acid-(4-(3-chloro-4-fluoro-phenylamino)-7-((S)-tetrahydrofuran-3-yloxy)-quinazolin-6-yl)-amide
(E)-4-Dimethylamino-but-2-enoic acid-[4-(3-chloro-4-fluoro-phenylamino)-7-((S)-tetrahydrofuran-3-yloxy)-quinazolin-6-yl]-amide
BIBW2992,Afatinib
Afatinib (USAN/INN)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight	485.95 g/molcalc.
Exact mass	485.163 Dacalc.
LogP (octanol/water)	4.39calc.
Topological polar surface area	88.61 Å²calc.
Hydrogen bond donors	2calc.
Hydrogen bond acceptors	7calc.
Rotatable bonds	8calc.
Heavy atoms	34calc.
Rings	4calc.
Aromatic rings	3calc.
Fraction sp3 carbons	0.29calc.
Formal charge	0calc.
Stereocentres	1calc.
Lipinski rule of five	Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

c1ccc(Nc2ncnc3cc(OC4CCOC4)ccc23)cc1

4 rings, 23 atoms.

46 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word

Warning

Harmful or irritant

Serious health hazard

Hazard statements

H302Harmful if swallowed.
H315Causes skin irritation.
H319Causes serious eye irritation.
H335May cause respiratory irritation.
H373May cause damage to organs through prolonged or repeated exposure.

Precautionary statements (20)

P260Do not breathe dust, fume, gas, mist, vapours or spray.
P261Avoid breathing dust, fume, gas, mist, vapours or spray.
P264Wash skin thoroughly after handling.
P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves, protective clothing, eye protection and face protection.
P301 + P317If swallowed: Get medical help.
P302 + P352If on skin: Wash with plenty of water.
P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P319Get medical help if you feel unwell.
P321Specific treatment (see supplemental first aid instructions on the label).
P330Rinse mouth.
P332 + P317If skin irritation occurs: Get medical help.
P337 + P317If eye irritation persists: Get medical help.
P362 + P364Take off contaminated clothing. And wash it before reuse.
P403 + P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Afatinib suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 109 suppliers

Verified only30 of 30 offers

Sakar Healthcare Limited
India, Ahmedabad ManufacturerUnclaimed profile
AfatinibGrade, purity and minimum order on request
Price on request
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Chuming Pharmaceutical Limited
ChinaUnclaimed profile
AfatinibGrade, purity and minimum order on request
Price on request
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Medkem
India, Hyderabad ManufacturerUnclaimed profile
AfatinibGrade, purity and minimum order on request
Price on request
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Jinan Lead Pharm-chemical Co., Ltd.
China, JinanUnclaimed profile
AfatinibGrade, purity and minimum order on request
Price on request
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Avd Pharmaceuticals Private Limited
India, Pune ManufacturerUnclaimed profile
AfatinibGrade, purity and minimum order on request
Price on request
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Tianjin Scipharmacn Limited
China, TianjinUnclaimed profile
AfatinibGrade, purity and minimum order on request
Price on request
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Lunan Pharmaceutical Group Corporation
ChinaUnclaimed profile
AfatinibGrade, purity and minimum order on request
Price on request
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Hangzhou CNRU Pharm&Chem Co., Ltd
China, HangzhouUnclaimed profile
AfatinibGrade, purity and minimum order on request
Price on request
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MSN Laboratories Private Limited
India ManufacturerUnclaimed profile
Afatinib dimaleate monohydrateGrade, purity and minimum order on request
Price on request
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Alembic Pharmaceuticals Limited
India, Vadodara ManufacturerUnclaimed profile
AfatinibGrade, purity and minimum order on request
Price on request
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

109 suppliers in 17 countries

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Afatinib price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Anticancer drugs in pharmaceuticals

Pharmacological actions

Antineoplastic Agents
Tyrosine Kinase Inhibitors

Roles

antineoplastic agent
enzyme inhibitor
pharmaceutical
protein kinase inhibitor
tyrosine kinase inhibitor

Pharmacology

Afatinib is a Kinase Inhibitor. The mechanism of action of afatinib is as a Protein Kinase Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Afatinib is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024

$26.7B

+15.0% vs 2023, imports $26.3B

2019 to 2024

Top exporters

Ireland26.3%
China15.7%
Singapore10.3%

Top importers

Reported customs values in USD, not prices.Full trade data

The HS code shown for Afatinib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Parent and salt forms, stereoisomers, similar structures and isomers

Salt and hydrate forms

Records that share this compound as their parent

Afatinib dimaleate chemical structure, C32H33ClFN5O11, CAS 850140-73-7

Afatinib dimaleate850140-73-7C₃₂H₃₃ClFN₅O₁₁49 suppliers

(S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide hydrochloride(1:x) chemical structure, C24H26Cl2FN5O3, CAS 1254955-21-9

(S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide hydrochloride(1:x)1254955-21-9C₂₄H₂₆Cl₂FN₅O₃

Afatinib oxalate chemical structure, C28H29ClFN5O11, CAS 1398312-64-5

Afatinib oxalate1398312-64-5C₂₈H₂₉ClFN₅O₁₁

Stereoisomers and isotopic forms

Same connectivity, different stereochemistry or isotopes (same InChIKey skeleton)

N-[4-(3-Chloro-4-fluoroanilino)-7-(3-oxolanyloxy)-6-quinazolinyl]-4-(dimethylamino)-2-butenamide chemical structure, C24H25ClFN5O3, CAS 439081-18-2

N-[4-(3-Chloro-4-fluoroanilino)-7-(3-oxolanyloxy)-6-quinazolinyl]-4-(dimethylamino)-2-butenamide439081-18-2C₂₄H₂₅ClFN₅O₃10 suppliers

(S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide chemical structure, C24H25ClFN5O3

(S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamideC₂₄H₂₅ClFN₅O₃

N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-Butenamide chemical structure, C24H25ClFN5O3, CAS 1427463-78-2

N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-Butenamide1427463-78-2C₂₄H₂₅ClFN₅O₃2 suppliers

Afatinib, (R)- chemical structure, C24H25ClFN5O3, CAS 945553-91-3

Afatinib, (R)-945553-91-3C₂₄H₂₅ClFN₅O₃2 suppliers

Afatinib-d6 chemical structure, C24H25ClFN5O3, CAS 1313874-96-2

Afatinib-d61313874-96-2C₂₄H₂₅ClFN₅O₃

(S,Z)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide chemical structure, C24H25ClFN5O3, CAS 1680184-59-1

(S,Z)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide1680184-59-1C₂₄H₂₅ClFN₅O₃

Similar structures

Nearest neighbours by Morgan fingerprint Tanimoto similarity

(S,E)-N-(4-((4-Chloro-3-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide chemical structure, C24H25ClFN5O3, CAS 2475094-87-0

N1,N2-Bis(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)oxalamide chemical structure, C38H30Cl2F2N8O6, CAS 2223677-65-2

(S)-N1-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-N2,N2-dimethyloxalamide chemical structure, C22H21ClFN5O4, CAS 2223677-66-3

(E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(prop-2-yn-1-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide chemical structure, C23H21ClFN5O2, CAS 1621002-27-4

(E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-fluoroquinazolin-6-yl)-4-(dimethylamino)but-2-enamide (Afatinib Impurity) chemical structure, C20H18ClF2N5O, CAS 2170273-17-1

Diethyl P-(2-((4-((3-chloro-4-fluorophenyl)amino)-7-(((3S)-tetrahydro-3-furanyl)oxy)-6-quinazolinyl)amino)-2-oxoethyl)phosphonate chemical structure, C24H27ClFN4O6P, CAS 618061-76-0

Same formula isomers

Different compounds that share this molecular formula

All isomers

Canertinib chemical structure, C24H25ClFN5O3, CAS 267243-28-7

Canertinib267243-28-7C₂₄H₂₅ClFN₅O₃9 suppliers

2-(2-Chloro-4-fluorobenzyl)-N-isobutyl-4-isopropyl-1,5-dioxo-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide chemical structure, C24H25ClFN5O3, CAS 1105214-44-5

2-(2-Chloro-4-fluorobenzyl)-N-isobutyl-4-isopropyl-1,5-dioxo-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide1105214-44-5C₂₄H₂₅ClFN₅O₃

2-(2-Chloro-4-fluorobenzyl)-N-isobutyl-1,5-dioxo-4-propyl-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide chemical structure, C24H25ClFN5O3, CAS 1105200-51-8

2-(2-Chloro-4-fluorobenzyl)-N-isobutyl-1,5-dioxo-4-propyl-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide1105200-51-8C₂₄H₂₅ClFN₅O₃

2-(2-Chloro-6-fluorobenzyl)-N-isobutyl-1,5-dioxo-4-propyl-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide chemical structure, C24H25ClFN5O3, CAS 1105247-51-5

2-(2-Chloro-6-fluorobenzyl)-N-isobutyl-1,5-dioxo-4-propyl-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide1105247-51-5C₂₄H₂₅ClFN₅O₃

N-(sec-Butyl)-2-(2-chloro-6-fluorobenzyl)-4-isopropyl-1,5-dioxo-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide chemical structure, C24H25ClFN5O3, CAS 1105228-20-3

N-(sec-Butyl)-2-(2-chloro-6-fluorobenzyl)-4-isopropyl-1,5-dioxo-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide1105228-20-3C₂₄H₂₅ClFN₅O₃

N-(sec-Butyl)-2-(2-chloro-6-fluorobenzyl)-1,5-dioxo-4-propyl-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide chemical structure, C24H25ClFN5O3, CAS 1105247-30-0

N-(sec-Butyl)-2-(2-chloro-6-fluorobenzyl)-1,5-dioxo-4-propyl-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide1105247-30-0C₂₄H₂₅ClFN₅O₃

(S,E)-N-(4-((4-Chloro-3-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide2475094-87-0C₂₄H₂₅ClFN₅O₃1 supplier

Afatinib impurity 109 chemical structure, C24H25ClFN5O3, CAS 2406199-31-1

Afatinib impurity 1092406199-31-1C₂₄H₂₅ClFN₅O₃

Frequently asked questions

Quick answers about Afatinib, based on the data on this page

What is Afatinib?

Afatinib is a quinazoline compound having a 3-chloro-4-fluoroanilino group at the 4-position, a 4-dimethylamino-trans-but-2-enamido group at the 6-position, and an (S)-tetrahydrofuran-3-yloxy group at the 7-position.

What is the CAS number of Afatinib?

The CAS registry number of Afatinib is 850140-72-6. Other or deprecated CAS numbers: 439081-18-2.

What is the molecular formula and weight of Afatinib?

The molecular formula of Afatinib is C24H25ClFN5O3 and its molar mass is 485.95 g/mol.

What is Afatinib used for?

Known uses and roles of Afatinib include anticancer drugs in pharmaceuticals, antineoplastic agent, enzyme inhibitor, pharmaceutical, protein kinase inhibitor and 3 more.

Is Afatinib hazardous?

Afatinib carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Afatinib?

Afatinib is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Afatinib?

CompoundList lists 109 suppliers of Afatinib in China, United States, India, Germany and 13 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Afatinib in India?

11 suppliers in India list Afatinib on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Afatinib?

Suppliers quote Afatinib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Afatinib

Afatinib

Key facts

What is Afatinib?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Murcko scaffold

Safety and hazards

Hazard statements

Afatinib suppliers

Where suppliers are based

Send one request to many suppliers

Afatinib price

Uses and applications

Industries and functions

Pharmacological actions

Roles

Pharmacology

Regulatory status

Health and food

HS code and trade data

Global trade

Frequently asked questions

What is Afatinib?

What is the CAS number of Afatinib?

What is the molecular formula and weight of Afatinib?

What is Afatinib used for?

Is Afatinib hazardous?

What is the HS code of Afatinib?

Where can I buy Afatinib?

Where can I buy Afatinib in India?

What is the price of Afatinib?

Guides for buyers

Get quotes for Afatinib

Key facts

What is Afatinib?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Murcko scaffold

Safety and hazards

Hazard statements

Afatinib suppliers

Where suppliers are based

Send one request to many suppliers

Afatinib price

Uses and applications

Industries and functions

Pharmacological actions

Roles

Pharmacology

Regulatory status

Health and food

HS code and trade data

Global trade

Related chemicals

Salt and hydrate forms

Stereoisomers and isotopic forms

Similar structures

Same formula isomers

Frequently asked questions

What is Afatinib?

What is the CAS number of Afatinib?

What is the molecular formula and weight of Afatinib?

What is Afatinib used for?

Is Afatinib hazardous?

What is the HS code of Afatinib?

Where can I buy Afatinib?

Where can I buy Afatinib in India?

What is the price of Afatinib?

Guides for buyers

Get quotes for Afatinib