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Antibiotics and anti-infectives

Amphotericin B

Also known as Amphotericine B, Amfotericina B, Halizon

CAS 1397-89-3Formula C47H73NO17Molar mass 924.09 g/molEC 215-742-2
GHS signal word: Warning. Pictograms: Harmful or irritant 106 suppliers listed Drug substance
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Amphotericin B chemical structure, C47H73NO17, CAS 1397-89-3
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Deep yellow prisms or needles from n,n-dimethylformamide
Melting point
170 °C
Solubility
Insol in water at pH 6-7, solubility in water at pH 2 or pH 11 about 0.1 mg/ml, water so…
HS code
294190
Category
Antibiotics and anti-infectives
Illustrative photo, yellow pigment powder in an open fibre drum in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Amphotericin B?

Plain description, key identifiers and synonyms

Amphotericin B is a macrolide antibiotic used to treat potentially life-threatening fungal infections. It has a role as an antiamoebic agent, an antiprotozoal drug and a bacterial metabolite. It is a macrolide antibiotic, a polyene antibiotic and an antibiotic antifungal drug.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
CAS number
1397-89-3 CAS number cross-checkedOther or deprecated CAS: 1202017-46-6
EC number
215-742-2
Molecular formula
C47H73NO17
UNII
7XU7A7DROE
MDL number
MFCD00877763
InChIKey
APKFDSVGJQXUKY-INPOYWNPSA-N
InChI
InChI=1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
Canonical SMILES
CC1C=CC=CC=CC=CC=CC=CC=CC(OC2OC(C)C(O)C(N)C2O)CC2OC(O)(CC(O)CC(O)C(O)CCC(O)CC(O)CC(=O)OC(C)C(C)C1O)CC(O)C2C(=O)O
Isomeric SMILES
C[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](C[C@H]2[C@@H]([C@H](C[C@](O2)(C[C@H](C[C@H]([C@@H](CC[C@H](C[C@H](CC(=O)O[C@H]([C@@H]([C@@H]1O)C)C)O)O)O)O)O)O)O)C(=O)O)O[C@H]3[C@H]([C@H]([C@@H]([C@H](O3)C)O)N)O

Synonyms

  • Amphotericine B
  • Amfotericina B
  • Halizon
  • Ampho-Moronal
  • Amphotericinum B
  • Fungizone
  • Amphocin
  • Amphotec
  • AmphotericinB
  • AMPH-B
  • Amphotocerin
  • Ambil
  • Fungilin
  • Amphozone
  • Amphomoronal
  • Amphotericin B liposome
  • Mysteclin-F
  • Amphotericin b, liposome
  • NS 718
  • Abelcet, liposomal amphotericin b
  • Fungisone
  • amophotericin B
  • Amphotercin B
  • Amphotreicin B
  • Ampotericin B
Show all 37 synonyms
  • Amphotericitin B
  • Amphotericinum
  • Fungilin In Orabase
  • Amphotericin
  • Abelcet
  • Ambisome
  • Amphotericin-B
  • Amphotericin B (85%)
  • Amphotericin B (~80%)
  • ABLC
  • Abelecet
  • Amphortericin B

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Deep yellow prisms or needles from n,n-dimethylformamideexp.
Odour
ODORLESS OR PRACTICALLY SOexp.
Melting point
170 °Cexp.
Solubility
Insol in water at pH 6-7, solubility in water at pH 2 or pH 11 about 0.1 mg/ml, water sol increased by sodium desoxycholateexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
924.09 g/molcalc.
Exact mass
923.4879 Dacalc.
LogP (octanol/water)
0.71calc.
Topological polar surface area
319.6 Ųcalc.
Hydrogen bond donors
12calc.
Hydrogen bond acceptors
17calc.
Rotatable bonds
3calc.
Heavy atoms
65calc.
Rings
3calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.66calc.
Formal charge
0calc.
Stereocentres
19calc.
Lipinski rule of five
Fails (3 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCCCCCCCCCCC2CCCC(CC(OC3CCCCO3)C=CC=CC=CC=CC=CC=CC=CCCCCO1)O2

O=C1CCCCCCCCCCCC2CCCC(CC(OC3CCCCO3)C=CC=CC=CC=CC=CC=CC=CCCCCO1)O2

3 rings, 47 atoms.

43 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Amphotericin B suppliers

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Where suppliers are based

106 suppliers in 17 countries

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Amphotericin B price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

Amphotericin B is an antifungal antibiotic produced from a strain of Streptomyces nodosus.

Therapeutic category: Antifungal.

Very high concentrations of amphotericin B increase the permeability of the sarcolemmal membrane, and electrophysiologists use the drug to create perforated patch-clamp models.

Pharmacological actions

  • Amebicides
  • Anti-Bacterial Agents
  • Antifungal Agents
  • Antiprotozoal Agents

Roles

  • antiamoebic agent
  • antibacterial agent
  • antihypertensive agent
  • antiinfective agent
  • antileishmanial agent
  • antimicrobial agent
  • antimicrobial drug
  • antineoplastic agent
  • antiparasitic agent
  • antiprotozoal drug
  • bacterial metabolite
  • cardiovascular drug
  • metabolite
  • pharmaceutical
  • prokaryotic metabolite

Pharmacology

Amphotericin b is a Lipid-based Polyene Antifungal and Polyene Antifungal.

How it is made

Dutcher et al., US patent 2,908,611 (1959 to Olin Mathieson)

Fermentation of Streptomyces nodosus cultures

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Amphotericin B is traded under.

HS 2941.90Indicative HS code

Antibiotics, other

World exports in 2024
$6.39B
+2.3% vs 2023, imports $6.97B
2019 to 2024
Top exporters
  1. China39.7%
  2. United States11.3%
  3. Switzerland * partner reported10.9%
Top importers
  1. Italy15.0%
  2. India * partner reported12.0%
  3. China8.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Amphotericin B is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Amphotericin B, based on the data on this page

What is Amphotericin B?

Amphotericin B is a macrolide antibiotic used to treat potentially life-threatening fungal infections. It has a role as an antiamoebic agent, an antiprotozoal drug and a bacterial metabolite. It is a macrolide antibiotic, a polyene antibiotic and an antibiotic antifungal drug.

What is the CAS number of Amphotericin B?

The CAS registry number of Amphotericin B is 1397-89-3. Other or deprecated CAS numbers: 1202017-46-6.

What is the molecular formula and weight of Amphotericin B?

The molecular formula of Amphotericin B is C47H73NO17 and its molar mass is 924.09 g/mol.

What is Amphotericin B used for?

Veterinary medication:. Amphotericin B is an antifungal antibiotic produced from a strain of Streptomyces nodosus. Therapeutic category: Antifungal.

Is Amphotericin B hazardous?

Amphotericin B carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Amphotericin B?

Amphotericin B is usually classified under HS code 294190 (Antibiotics, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Amphotericin B?

CompoundList lists 106 suppliers of Amphotericin B in United States, China, India, Germany and 13 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Amphotericin B in India?

18 suppliers in India list Amphotericin B on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Amphotericin B?

Suppliers quote Amphotericin B on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Amphotericin B

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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