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Cardiovascular and metabolic drugs

Anagrelide

Also known as Anagrelida, Anagrelidum, 6,7-dichloro-1H,2H,3H,5H-imidazolidino[2,1-b]quinazolin-2-one

CAS 68475-42-3Formula C10H7Cl2N3OMolar mass 256.09 g/molEC 864-866-9
GHS signal word: Danger. Pictograms: Serious health hazard 71 suppliers listed Drug substance
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Anagrelide chemical structure, C10H7Cl2N3O, CAS 68475-42-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
68475-42-3
Formula
C10H7Cl2N3O
Molar mass
256.09 g/mol
Solubility
In water, 1,300 mg/L at 25 °C /Estimated/
HS code
293359
Category
Cardiovascular and metabolic drugs

What is Anagrelide?

Plain description, key identifiers and synonyms

Anagrelide is a 1,5-dihydroimidazo[2,1-]quinazoline having an oxo substituent at the 2-position and chloro substituents at the 6- and 7-positions. It has a role as a cardiovascular drug, an antifibrinolytic drug, an anticoagulant and a platelet aggregation inhibitor.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
6,7-dichloro-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-one
CAS number
68475-42-3 CAS number cross-checked
EC number
864-866-9
Molecular formula
C10H7Cl2N3O
UNII
K9X45X0051
MDL number
MFCD00866794
InChIKey
OTBXOEAOVRKTNQ-UHFFFAOYSA-N
InChI
InChI=1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16)
SMILES (canonical and isomeric)
C1C2=C(C=CC(=C2Cl)Cl)N=C3N1CC(=O)N3

Synonyms

  • Anagrelida
  • Anagrelidum
  • 6,7-dichloro-1H,2H,3H,5H-imidazolidino[2,1-b]quinazolin-2-one
  • 6,7-dichloro-3H,5H-imidazo(2,1-b)quinazolin-2-ol
  • 6,7-dichloro-3H,5H-imidazo[2,1-b]quinazolin-2-ol
  • 6,7-dichloro-1H,2H,3H,5H-imidazolidino(2,1-b)quinazolin-2-one
  • 6,7-Dichloro-5,10-dihydroimidazo[2,1-b]quinazolin-2(3H)-one
  • Xagrid
  • 6,7-dichloro-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one
  • Anagrelide (INN/BAN)
  • Agrelin
  • 6,7-Dichloro-1,5-dihydroimidazo(2,1-b)quinazolin-2(3H)-one
  • Imidazo[2,1-b]quinazolin-2(3H)-one, 6,7-dichloro-1,5-dihydro-
  • 6,7-Dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one
  • 6,7-dichloro-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-one
  • 6,7-bis(chloranyl)-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-one
  • Imidazo(2,1-b)quinazolin-2(3H)-one, 6,7-dichloro-1,5-dihydro-
  • BL 416201
  • 6,7-dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2[3H]-one
  • 6,7-Dichlor-1,5-dihydroimidazo(2,1-b)chinazolin-2(3H)-on
  • Anagrelide(13C3)
  • 6,7-dichloro-1,5-dihydroimidazo[2,1-]quinazolin-2(3H)-one
  • 6,7-dichloro-1H,2H,3H,5H-imidazo[2,1-b]quinazolin-2-one
  • 6,7-Dichloro-1,5-dihydroimidazo(2,1-b)quinazoli
  • 6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-2-one

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Solubility
In water, 1,300 mg/L at 25 °C /Estimated/exp.
Vapour pressure
6.8 × 10⁻¹⁰ mm Hg at 25 °C /Estimated/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
256.09 g/molcalc.
Exact mass
254.9966 Dacalc.
LogP (octanol/water)
1.93calc.
Topological polar surface area
44.7 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
0calc.
Heavy atoms
16calc.
Rings
3calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.2calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CN2Cc3ccccc3N=C2N1

O=C1CN2Cc3ccccc3N=C2N1

3 rings, 14 atoms, the Imidazo[2,1-b]quinazolin-2(3H)-one, 1,5-dihydro- ring system.

29 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
  • H360May damage fertility or the unborn child.
Precautionary statements (21)
  • P203Obtain, read and follow all safety instructions before use.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Anagrelide suppliers

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All 71 suppliers
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Where suppliers are based

71 suppliers in 13 countries

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Anagrelide price

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Uses and applications

What the substance is used for, by industry and function

Medication: Antithrombocythemic.

Reduces blood platelet count ... for the treatment of myeloproliferative disorders (Hydrochloride).

Pharmacological actions

  • Fibrinolytic Agents
  • Platelet Aggregation Inhibitors

Roles

  • anticoagulant
  • antifibrinolytic drug
  • antineoplastic agent
  • cardiovascular drug
  • fibrin modulating drug
  • hematologic agent
  • pharmaceutical
  • platelet aggregation inhibitor

Pharmacology

Anagrelide is a Platelet-reducing Agent. The mechanism of action of anagrelide is as a Phosphodiesterase 3 Inhibitor. The physiologic effect of anagrelide is by means of Decreased Platelet Production.

How it is made

Preparation: W. N. Beverung, A. Partyka, US 3932407, US RE 31617, T. A. Jenks et al., US 4146781 (1976,1984, 1979 all to Bristol-Myers)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Anagrelide is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Anagrelide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Anagrelide, based on the data on this page

What is Anagrelide?

Anagrelide is a 1,5-dihydroimidazo[2,1-]quinazoline having an oxo substituent at the 2-position and chloro substituents at the 6- and 7-positions. It has a role as a cardiovascular drug, an antifibrinolytic drug, an anticoagulant and a platelet aggregation inhibitor.

What is the CAS number of Anagrelide?

The CAS registry number of Anagrelide is 68475-42-3.

What is the molecular formula and weight of Anagrelide?

The molecular formula of Anagrelide is C10H7Cl2N3O and its molar mass is 256.09 g/mol.

What is Anagrelide used for?

Medication: Antithrombocythemic. Reduces blood platelet count ... for the treatment of myeloproliferative disorders (Hydrochloride).

Is Anagrelide hazardous?

Anagrelide carries the GHS signal word "Danger". Main hazards: harmful if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Anagrelide?

Anagrelide is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Anagrelide?

CompoundList lists 71 suppliers of Anagrelide in United States, China, India, United Kingdom and 9 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Anagrelide in India?

7 suppliers in India list Anagrelide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Anagrelide?

Suppliers quote Anagrelide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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