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Heterocyclic compounds

Antibiotic K 252a

Also known as k-252a, K252a, Antibiotic SF 2370

CAS 99533-80-9Formula C27H21N3O5Molar mass 467.48 g/molEC 640-127-4
GHS signal word: Warning. Pictograms: Harmful or irritant 7 suppliers listed
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Antibiotic K 252a chemical structure, C27H21N3O5, CAS 99533-80-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
99533-80-9
Formula
C27H21N3O5
Molar mass
467.48 g/mol
EC number
640-127-4
HS code
293499
Category
Heterocyclic compounds

What is Antibiotic K 252a?

Plain description, key identifiers and synonyms

K-252a is a organic heterooctacyclic compound that is a potent inhibitor of protein kinase C and is isolated from Nocardiopsis sp K-252a. It has a role as an antimicrobial agent, an EC 2.7.11.13 (protein kinase C) inhibitor, a bacterial metabolite and a tropomyosin-related kinase B receptor antagonist. It is a methyl ester, a bridged compound, an organic heterooctacyclic compound and a gamma-lactam.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
methyl (15S,16R,18R)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaene-16-carboxylate
CAS number
99533-80-9 CAS number cross-checkedOther or deprecated CAS: 97161-97-2
EC number
640-127-4
Molecular formula
C27H21N3O5
UNII
IV7H45AM5B
MDL number
MFCD00161522
InChIKey
KOZFSFOOLUUIGY-SOLYNIJKSA-N
InChI
InChI=1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1
Canonical SMILES
COC(=O)C1(O)CC2OC1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4
Isomeric SMILES
C[C@@]12[C@](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)OC)O

Synonyms

  • k-252a
  • K252a
  • Antibiotic SF 2370
  • K 252a
  • Protein kinase inhibitor k252a
  • SF 2370
  • (+)-Antibiotic K 252a
  • (+)-K-252A
  • 1r0p
  • K-252a, from Nocardiopsis sp.
  • (+)-k252a
  • (+)-Antibiotic sf 2370
  • Antibiotic k 252a, (+)-
  • Antibiotic sf 2370, (+)-
  • (+)-K 252A
  • (+)-SF 2370
  • K-252a, from Nocardiopsis sp., >=96.0% (HPLC)
  • K-252a, from Nonomuraea longicatena, >=98% (HPLC)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
467.48 g/molcalc.
Exact mass
467.1481 Dacalc.
LogP (octanol/water)
3.66calc.
Topological polar surface area
94.72 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
1calc.
Heavy atoms
35calc.
Rings
8calc.
Aromatic rings
5calc.
Fraction sp3 carbons
0.26calc.
Formal charge
0calc.
Stereocentres
3calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1NCc2c1c1c3ccccc3n3c1c1c2c2ccccc2n1C1CCC3O1

O=C1NCc2c1c1c3ccccc3n3c1c1c2c2ccccc2n1C1CCC3O1

8 rings, 29 atoms.

25 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Antibiotic K 252a suppliers

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Where suppliers are based

7 suppliers in 5 countries

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Antibiotic K 252a price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antagonist
  • antimicrobial agent
  • bacterial metabolite
  • enzyme inhibitor
  • metabolite
  • prokaryotic metabolite
  • protein kinase inhibitor
  • tropomyosin-related kinase B receptor antagonist

Pharmacology

K 252a is an indolocarbazole-based alkaloid and staurosporine analog isolated from Nocardiopsis and Actinomadura species, with kinase inhibiting activity. K252a inhibits a wide variety of enzymes, including, but not limited to, protein kinase A (PKA), C (PKC) and G (PKG), calcium (Ca2+)/calmodulin-dependent kinase type II (CaMKII), phosphorylase kinase (PhK), tropomyosin receptor kinase (Trk, neurotrophic tyrosine receptor kinase, NTRK), myosin light-chain kinase (MLCK, MYLK), mixed-lineage protein kinase 3 (MLK3), receptor-type tyrosine-protein kinase FLT3 (CD135, fms-like tyrosine kinase 3, fetal liver kinase-2, FLK2) and actin-regulating kinase PRK1 (PAK1). Inhibition of these kinases prevents the activation of signaling pathways in which these kinases play a key role.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Antibiotic K 252a is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Antibiotic K 252a is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Antibiotic K 252a, based on the data on this page

What is Antibiotic K 252a?

K-252a is a organic heterooctacyclic compound that is a potent inhibitor of protein kinase C and is isolated from Nocardiopsis sp K-252a. It has a role as an antimicrobial agent, an EC 2.7.11.13 (protein kinase C) inhibitor, a bacterial metabolite and a tropomyosin-related kinase B receptor antagonist.

What is the CAS number of Antibiotic K 252a?

The CAS registry number of Antibiotic K 252a is 99533-80-9. Other or deprecated CAS numbers: 97161-97-2.

What is the molecular formula and weight of Antibiotic K 252a?

The molecular formula of Antibiotic K 252a is C27H21N3O5 and its molar mass is 467.48 g/mol.

What is Antibiotic K 252a used for?

Known uses and roles of Antibiotic K 252a include antagonist, antimicrobial agent, bacterial metabolite, enzyme inhibitor, metabolite and 3 more.

Is Antibiotic K 252a hazardous?

Antibiotic K 252a carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Antibiotic K 252a?

Antibiotic K 252a is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Antibiotic K 252a?

CompoundList lists 7 suppliers of Antibiotic K 252a in United States, Australia, China, United Kingdom and 1 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Antibiotic K 252a?

Suppliers quote Antibiotic K 252a on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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