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Alkaloids

Antofine

Also known as (-)-antofine, (13aR)-2,3,6-trimethoxy-9,11,12,13,13a,14-hexahydrophenanthro[9,10-f]indolizine, dibenzo[f,h]pyrrolo[1,2-b]isoquinoline, 9,11,12,13,13a,14-hexahydro-2,3,6-trimethoxy-, (13aR)-

CAS 32671-82-2Formula C23H25NO3Molar mass 363.46 g/molEC 112-610-5
GHS signal word: Danger. Pictograms: Acute toxicity (severe)
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Antofine chemical structure, C23H25NO3, CAS 32671-82-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
32671-82-2
Formula
C23H25NO3
Molar mass
363.46 g/mol
EC number
112-610-5
HS code
293979
Category
Alkaloids

What is Antofine?

Plain description, key identifiers and synonyms

(-)-antofine is an organic heteropentacyclic compound that is (13aR)-9,11,12,13,13a,14-hexahydrodibenzo[f,h]pyrrolo[1,2-b]isoquinoline substituted at positions 2, 3 and 6 by methoxy groups. It is an alkaloid produced by relatives of the milkweed family and exhibits antiviral, anti-inflammatory, antiadipogenic and antitumorigenic activities. It has a role as an antiviral agent, an antimicrobial agent, an antineoplastic agent, a phytotoxin, an angiogenesis inhibitor, an anti-inflammatory agent and a plant metabolite. It is an alkaloid, an aromatic ether, an organic heteropentacyclic compound and an alkaloid antibiotic.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(13aR)-2,3,6-trimethoxy-9,11,12,13,13a,14-hexahydrophenanthro[9,10-f]indolizine
CAS number
32671-82-2Other or deprecated CAS: 26648-81-7
EC number
112-610-5
Molecular formula
C23H25NO3
InChIKey
NCVWJDISIZHFQS-CQSZACIVSA-N
InChI
InChI=1S/C23H25NO3/c1-25-15-6-7-16-18(10-15)20-12-23(27-3)22(26-2)11-19(20)17-9-14-5-4-8-24(14)13-21(16)17/h6-7,10-12,14H,4-5,8-9,13H2,1-3H3/t14-/m1/s1
Canonical SMILES
COc1ccc2c3c(c4cc(OC)c(OC)cc4c2c1)CC1CCCN1C3
Isomeric SMILES
COC1=CC2=C(C=C1)C3=C(C[C@H]4CCCN4C3)C5=CC(=C(C=C52)OC)OC

Synonyms

  • (-)-antofine
  • (13aR)-2,3,6-trimethoxy-9,11,12,13,13a,14-hexahydrophenanthro[9,10-f]indolizine
  • dibenzo[f,h]pyrrolo[1,2-b]isoquinoline, 9,11,12,13,13a,14-hexahydro-2,3,6-trimethoxy-, (13aR)-
  • (13aR)-2,3,6-trimethoxy-9,11,12,13,13a,14-hexahydrodibenzo[f,h]pyrrolo[1,2-b]isoquinoline
  • (R)-2,3,6-trimethoxy-9,11,12,13,13a,14-hexahydrodibenzo[f,h]pyrrolo[1,2-b]isoquinoline
  • 2,3,6-trimethoxy-9,11,12,13,13a,14-hexahydrodibenzo[f,h]pyrrolo[1,2-b]isoquinoline
  • (R)-antofine
  • 7-Demethoxytylophorine
  • (R)-(-)-antofine
  • 2,3,6-trimethoxy-9,10,11,12,12a,13-hexahydro-9a-aza-cyclopenta[b]triphenylene
  • 9,11,12,13,13a,14-hexahydro-2,3,6-trimethoxydibenzo[f,h]pyrrolo[1,2-b]isoquinoline

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
363.46 g/molcalc.
Exact mass
363.1834 Dacalc.
LogP (octanol/water)
4.54calc.
Topological polar surface area
30.93 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
3calc.
Heavy atoms
27calc.
Rings
5calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.39calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)c1c(c3ccccc32)CN2CCCC2C1

c1ccc2c(c1)c1c(c3ccccc32)CN2CCCC2C1

5 rings, 21 atoms, the 9,11,12,13,13a,14-Hexahydrophenanthro[9,10-f]indolizine ring system.

19 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H301Toxic if swallowed.
Precautionary statements (7)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Antofine suppliers

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Antofine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • angiogenesis inhibitor
  • anti-inflammatory agent
  • antimicrobial agent
  • antineoplastic agent
  • antiviral agent
  • eukaryotic metabolite
  • metabolite
  • pharmaceutical
  • phytotoxin
  • plant metabolite
  • poison
  • toxin

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Antofine is traded under.

HS 2939.79Indicative HS code

Alkaloids of vegetal origin, other than cocaine, ecgonine, salts, esters and other derivatives, not elsewhere…

World exports in 2024
$701M
+18.9% vs 2023, imports $830M
2019 to 2024
Top exporters
  1. Switzerland * partner reported25.3%
  2. Germany21.4%
  3. India * partner reported14.9%
Top importers
  1. United States20.9%
  2. Germany14.7%
  3. Italy14.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Antofine is indicative (it is known at chapter level only). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Antofine, based on the data on this page

What is Antofine?

(-)-antofine is an organic heteropentacyclic compound that is (13aR)-9,11,12,13,13a,14-hexahydrodibenzo[f,h]pyrrolo[1,2-b]isoquinoline substituted at positions 2, 3 and 6 by methoxy groups.

What is the CAS number of Antofine?

The CAS registry number of Antofine is 32671-82-2. Other or deprecated CAS numbers: 26648-81-7.

What is the molecular formula and weight of Antofine?

The molecular formula of Antofine is C23H25NO3 and its molar mass is 363.46 g/mol.

What is Antofine used for?

Known uses and roles of Antofine include angiogenesis inhibitor, anti-inflammatory agent, antimicrobial agent, antineoplastic agent, antiviral agent and 7 more.

Is Antofine hazardous?

Antofine carries the GHS signal word "Danger". Main hazards: toxic if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Antofine?

Antofine is usually classified under HS code 293979 (Alkaloids, natural or reproduced by synthesis, and their salts, ethers, esters and other…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Antofine?

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What is the price of Antofine?

Suppliers quote Antofine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Antofine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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