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Cardiovascular and metabolic drugs

Apixaban

Also known as Eliquis, 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide, BMS 562247-01

CAS 503612-47-3Formula C25H25N5O4Molar mass 459.51 g/molEC 639-684-6
GHS signal word: Danger. Pictograms: Serious health hazard 218 suppliers listed Drug substance
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Apixaban chemical structure, C25H25N5O4, CAS 503612-47-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
503612-47-3
Formula
C25H25N5O4
Appearance
White to pale-yellow powder
Solubility
Aqueous solubility across the physiological pH range is approximately 0.04 mg/L
HS code
293339
Category
Cardiovascular and metabolic drugs
Illustrative photo, white powder in small glass vials on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Apixaban?

Plain description, key identifiers and synonyms

Apixaban is a pyrazolopyridine that is 7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide substituted at position 1 by a 4-methoxyphenyl group and at position 6 by a 4-(2-oxopiperidin-1-yl)phenyl group. It is used for the prevention and treatment of thromboembolic diseases. It has a role as an anticoagulant and an EC 3.4.21.6 (coagulation factor Xa) inhibitor. It is a lactam, an aromatic ether, a pyrazolopyridine and a member of piperidones.

Apixaban is an anticoagulant medication.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[5,4-c]pyridine-3-carboxamide
CAS number
503612-47-3 CAS number cross-checked
EC number
639-684-6
Molecular formula
C25H25N5O4
UNII
3Z9Y7UWC1J
MDL number
MFCD11977295
InChIKey
QNZCBYKSOIHPEH-UHFFFAOYSA-N
InChI
InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32)
SMILES (canonical and isomeric)
COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N

Synonyms

  • Eliquis
  • 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
  • BMS 562247-01
  • 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
  • apixabanum
  • 1H-Pyrazolo[3,4-c]pyridine-3-carboxamide, 4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-
  • 1H-Pyrazolo(3,4-c)pyridine-3-carboxamide,4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxo-1-piperidinyl)phenyl)-
  • 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo(3,4-c)pyridine-3-carboxamide
  • 1H-Pyrazolo(3,4-c)pyridine-3-carboxamide, 4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxo-1-piperidinyl)phenyl)-
  • ELIQUIS 30-Day Starter Pack
  • 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxamide
  • Apixaban 13CD3
  • 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide
  • 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[5,4-c]pyridine-3-carboxamide
  • 1H-Pyrazolo(3,4-c)pyridine-3-carboxamide, 4,5,6,7-tetrahydro-1-( 4-methoxyphenyl)-7-oxo-6-(4-(2-oxo-1-piperidinyl)phenyl)-
  • Eliquis (TN)
  • Apixaban (JAN/USAN/INN)
  • Apixaban (Standard)
  • BMS 562247
  • Apixaban - Bio-X trade mark
  • Apixaban,BMS-562247-01
  • Apixaban (BMS 562247-01)
  • Apixaban (BMS 562247-01)?
  • 1-(4-Methoxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White to pale-yellow powderexp.
Solubility
Aqueous solubility across the physiological pH range is approximately 0.04 mg/Lexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
459.51 g/molcalc.
Exact mass
459.1907 Dacalc.
LogP (octanol/water)
2.7calc.
Topological polar surface area
110.8 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
5calc.
Heavy atoms
34calc.
Rings
5calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.28calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCCCN1c1ccc(N2CCc3cnn(-c4ccccc4)c3C2=O)cc1

O=C1CCCCN1c1ccc(N2CCc3cnn(-c4ccccc4)c3C2=O)cc1

5 rings, 29 atoms.

31 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H372Causes damage to organs through prolonged or repeated exposure.
Precautionary statements (5)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P319Get medical help if you feel unwell.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Apixaban suppliers

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All 218 suppliers
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Where suppliers are based

218 suppliers in 24 countries

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Apixaban price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Factor Xa Inhibitors

Roles

  • anti-anaemic agent
  • anti-arrhythmia drug
  • anticoagulant
  • antimicrobial agent
  • antineoplastic agent
  • antiviral agent
  • cardiovascular drug
  • enzyme inhibitor
  • hematologic agent
  • hepatoprotective agent
  • pharmaceutical
  • protective agent

Pharmacology

Apixaban is a Factor Xa Inhibitor. The mechanism of action of apixaban is as a Factor Xa Inhibitor.

How it is made

Preparation: D. Pinto et al., World Intellectual Property Organization patent 03026652, eidem, United States of America patent 6967208 (2003, 2005 both to Bristol-Myers Squibb).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Apixaban is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Apixaban is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Apixaban, based on the data on this page

What is Apixaban?

Apixaban is a pyrazolopyridine that is 7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide substituted at position 1 by a 4-methoxyphenyl group and at position 6 by a 4-(2-oxopiperidin-1-yl)phenyl group. It is used for the prevention and treatment of thromboembolic diseases.

What is the CAS number of Apixaban?

The CAS registry number of Apixaban is 503612-47-3.

What is the molecular formula and weight of Apixaban?

The molecular formula of Apixaban is C25H25N5O4 and its molar mass is 459.51 g/mol.

What is Apixaban used for?

Known uses and roles of Apixaban include cardiovascular drugs in pharmaceuticals, anti-anaemic agent, anti-arrhythmia drug, anticoagulant, antimicrobial agent and 9 more.

Is Apixaban hazardous?

Apixaban carries the GHS signal word "Danger". Main hazards: causes damage to organs through prolonged or repeated exposure. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Apixaban?

Apixaban is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Apixaban?

CompoundList lists 218 suppliers of Apixaban in China, India, United States, Germany and 20 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Apixaban in India?

54 suppliers in India list Apixaban on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Apixaban?

Suppliers quote Apixaban on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Apixaban

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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