CompoundList
Sign in
Cosmetic antioxidants

Arbutin

Also known as Arbutoside, Ursin, beta-Arbutin

CAS 497-76-7Formula C12H16O7Molar mass 272.25 g/molEC 207-850-3
137 suppliers listed Drug substance
Get quotes Compare 137 suppliers
Arbutin chemical structure, C12H16O7, CAS 497-76-7
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless elongated prisms from moist ethyl acetate
Melting point
199 °C
Solubility
Soluble in water and alcohol
HS code
293299
Category
Cosmetic antioxidants
Illustrative photo, colourless crystals in an open woven sack in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Arbutin?

Plain description, key identifiers and synonyms

Hydroquinone O-beta-D-glucopyranoside is a monosaccharide derivative that is hydroquinone attached to a beta-D-glucopyranosyl residue at position 4 via a glycosidic linkage. It has a role as a plant metabolite and an Escherichia coli metabolite. It is a beta-D-glucoside and a monosaccharide derivative. It is functionally related to a hydroquinone.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)oxane-3,4,5-triol
CAS number
497-76-7 CAS number cross-checked
EC number
207-850-3
Molecular formula
C12H16O7
UNII
C5INA23HXF
MDL number
MFCD00016915
INCI name
ARBUTIN
InChIKey
BJRNKVDFDLYUGJ-RMPHRYRLSA-N
InChI
InChI=1S/C12H16O7/c13-5-8-9(15)10(16)11(17)12(19-8)18-7-3-1-6(14)2-4-7/h1-4,8-17H,5H2/t8-,9-,10+,11-,12-/m1/s1
Canonical SMILES
OCC1OC(Oc2ccc(O)cc2)C(O)C(O)C1O
Isomeric SMILES
C1=CC(=CC=C1O)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O

Synonyms

  • Arbutoside
  • Ursin
  • beta-Arbutin
  • Uvasol
  • p-Hydroxyphenyl beta-D-glucoside
  • Arbutinum
  • 4-Hydroxyphenyl-beta-D-glucopyranoside
  • Hydroquinone-O-beta-D-glucopyranoside
  • Hydroquinone glucose
  • Hydroquinone-beta-D-glucopyranoside
  • hydroquinone O-beta-D-glucopyranoside
  • (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)oxane-3,4,5-triol
  • beta-D-Glucopyranoside, 4-hydroxyphenyl
  • Bright Boost Cream
  • DRUGGIST Cream
  • skin brightening cream
  • HYDRO H
  • bright moisturizing cream
  • DRUGGIST Whitening Cream
  • DRUGGIST Brightening cream
  • Vitamin C Brightening Cream
  • Brightening Kojic Acid Cream
  • DRUGGIST Bright Boost Cream
  • 4-hydroxyphenyl-glucopyranoside
  • Tosowoong Mens Booster Repair Skin
Show all 37 synonyms
  • ICEKING Freckle Removing Whitening Masque
  • Sooryehan Pure-Whitening Essential Starter
  • ICEKING Whitening Freckle Removing Essence
  • deep moisture and nourishment whitening cream
  • Dr Young 2p Brightening UV Sun Block SPF50 PA
  • Isaknox white symphony brightening emulsion
  • ICEKING Freckle Removing Whitening Facial Cleanser
  • 4-Hydroxyphenyl beta-D-glucopyranoside
  • p-Arbutin
  • p-Hydroxyphenyl beta-D-glucopyranoside
  • (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)tetrahydro-2H-pyran-3,4,5-triol
  • Hydroquinone beta-D-glucopyranoside

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless elongated prisms from moist ethyl acetateexp.
Melting point
199 °Cexp.
Solubility
Soluble in water and alcoholexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
272.25 g/molcalc.
Exact mass
272.0896 Dacalc.
LogP (octanol/water)
-1.43calc.
Topological polar surface area
119.6 Ųcalc.
Hydrogen bond donors
5calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
3calc.
Heavy atoms
19calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.5calc.
Formal charge
0calc.
Stereocentres
5calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(OC2CCCCO2)cc1

c1ccc(OC2CCCCO2)cc1

2 rings, 13 atoms, the 2H-Pyran, tetrahydro-2-phenoxy- ring system.

1,051 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Arbutin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 137 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

137 suppliers in 18 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Arbutin price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

In cosmetics as skin lightening agent.

Oxidation inhibitor, polymerization inhibitor, color stabilizer in photography, intermediate.

Herbal remedy.

Arbutin has been sugggested as a potential antitussive.

Use classes: Cosmetics.

Cosmetic ingredient, INCI name ARBUTIN(antioxidant, bleaching, skin conditioning - miscellaneous)

Roles

  • Escherichia coli metabolite
  • bacterial metabolite
  • eukaryotic metabolite
  • metabolite
  • plant metabolite
  • prokaryotic metabolite

Functional uses

  • Antioxidant
  • Bleaching agent
  • Softener and conditioner

Cosmetic functions

  • Antioxidant
  • Bleaching
  • Skin conditioning - miscellaneous

How it is made

Pure arbutin can be prepared synthetically from acetobromoglucose and hydroquinone in the presence of alkali

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • EU Cosmetics Regulation Annex III, restricted in cosmetics
    Name: Arbutin, Ref no: 378, Annex ref: III/378
  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Arbutin is traded under.

HS 2932.99Indicative HS code

Heterocyclic compounds with oxygen hetero-atom(s) only, other

World exports in 2024
$3.81B
+10.3% vs 2023, imports $7.05B
2019 to 2024
Top exporters
  1. China28.9%
  2. Switzerland * partner reported12.7%
  3. Germany7.8%
Top importers
  1. United States49.7%
  2. China11.9%
  3. India * partner reported3.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Arbutin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Arbutin, based on the data on this page

What is Arbutin?

Hydroquinone O-beta-D-glucopyranoside is a monosaccharide derivative that is hydroquinone attached to a beta-D-glucopyranosyl residue at position 4 via a glycosidic linkage. It has a role as a plant metabolite and an Escherichia coli metabolite. It is a beta-D-glucoside and a monosaccharide derivative.

What is the CAS number of Arbutin?

The CAS registry number of Arbutin is 497-76-7.

What is the molecular formula and weight of Arbutin?

The molecular formula of Arbutin is C12H16O7 and its molar mass is 272.25 g/mol.

What is Arbutin used for?

In cosmetics as skin lightening agent. Oxidation inhibitor, polymerization inhibitor, color stabilizer in photography, intermediate. Herbal remedy. Arbutin has been sugggested as a potential antitussive. Use classes: Cosmetics.

Is Arbutin hazardous?

No GHS hazard classification for Arbutin is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Arbutin?

Arbutin is usually classified under HS code 293299 (Heterocyclic compounds with oxygen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Arbutin?

CompoundList lists 137 suppliers of Arbutin in China, United States, United Kingdom, Germany and 14 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Arbutin in India?

3 suppliers in India list Arbutin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Arbutin?

Suppliers quote Arbutin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Arbutin

Get quotes for Arbutin

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Arbutin
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Arbutin with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/arbutin-497-76-7" title="Arbutin structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Cosmetic antioxidants or HS code 293299

137 suppliers
Free quotes, contact stays private
Get quotes