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Oncology and immunology drugs

Asciminib

Also known as N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3R)-3-hydroxypyrrolidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide, 3-Pyridinecarboxamide, N-[4-(chlorodifluoromethoxy)phenyl]-6-[(3R)-3-hydroxy-1-pyrrolidinyl]-5-(1H-pyrazol-3-yl)-, 3-Pyridinecarboxamide, N-(4-(chlorodifluoromethoxy)phenyl)-6-((3R)-3-hydroxy-1-pyrrolidinyl)-5-(1H-pyrazol-3-yl)-

CAS 1492952-76-7Formula C20H18ClF2N5O3Molar mass 449.85 g/molEC 841-613-0
16 suppliers listed Drug substance
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Asciminib chemical structure, C20H18ClF2N5O3, CAS 1492952-76-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1492952-76-7
Formula
C20H18ClF2N5O3
Molar mass
449.85 g/mol
EC number
841-613-0
HS code
293339
Category
Oncology and immunology drugs

What is Asciminib?

Plain description, key identifiers and synonyms

Asciminib is an orally bioavailable, allosteric Bcr-Abl1 tyrosine kinase inhibitor, with antineoplastic activity. Upon administration, asciminib targets and binds to the myristoyl pocket of the Bcr-Abl1 fusion protein at a location that is distinct from the ATP-binding domain, thereby inhibiting the activity of both wild-type Bcr-Abl and certain mutation forms, including the T315I mutation. This binding results in the inhibition of Bcr-Abl1-mediated proliferation and enhanced apoptosis of Philadelphia chromosome-positive (Ph+) hematological malignancies. The Bcr-Abl1 fusion protein tyrosine kinase is an abnormal enzyme produced by leukemia cells that contain the Philadelphia chromosome.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3R)-3-hydroxypyrrolidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide
CAS number
1492952-76-7
EC number
841-613-0
Molecular formula
C20H18ClF2N5O3
UNII
L1F3R18W77
InChIKey
VOVZXURTCKPRDQ-CQSZACIVSA-N
InChI
InChI=1S/C20H18ClF2N5O3/c21-20(22,23)31-15-3-1-13(2-4-15)26-19(30)12-9-16(17-5-7-25-27-17)18(24-10-12)28-8-6-14(29)11-28/h1-5,7,9-10,14,29H,6,8,11H2,(H,25,27)(H,26,30)/t14-/m1/s1
Canonical SMILES
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CCC(O)C2)c(-c2ccn[nH]2)c1
Isomeric SMILES
C1CN(C[C@@H]1O)C2=C(C=C(C=N2)C(=O)NC3=CC=C(C=C3)OC(F)(F)Cl)C4=CC=NN4

Synonyms

  • N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3R)-3-hydroxypyrrolidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide
  • 3-Pyridinecarboxamide, N-[4-(chlorodifluoromethoxy)phenyl]-6-[(3R)-3-hydroxy-1-pyrrolidinyl]-5-(1H-pyrazol-3-yl)-
  • 3-Pyridinecarboxamide, N-(4-(chlorodifluoromethoxy)phenyl)-6-((3R)-3-hydroxy-1-pyrrolidinyl)-5-(1H-pyrazol-3-yl)-
  • asciminibum
  • N-(4-(chloro(difluoro)methoxy)phenyl)-6-((3R)-3-hydroxypyrrolidin-1-yl)-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide
  • N-(4-(chlorodifluoromethoxy)phenyl)-6-((3R)-3-hydroxypyrrolidin-1-yl)-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide
  • Asciminib free base
  • Asciminib (ABL001)
  • (R)-N-(4-(Chlorodifluoromethoxy)phenyl)-6-(3-hydroxypyrrolidin-1-yl)-5-(1H-pyrazol-5-yl)nicotinamide
  • Example 9
  • (R)-N-(4-(Chlorodifluoromethoxy)phenyl)-6-(3-hydroxypyrrolidin-1-yl)-5-(1H-pyrazol-3-yl)nicotinamide
  • N-[4-(chlorodifluoromethoxy)phenyl]-6-[(3r)-3-hydroxypyrrolidin-1-yl]-5-(1h-pyrazol-3-yl)pyridine-3-carboxamide
  • C20H18ClF2N5O3
  • Asciminib?
  • Asciminib (Standard)
  • 1492952-76-7 (free base)
  • Asciminib (USAN/INN)
  • Abl-0013-pyridinecarboxamide
  • compound 1
  • (R)-N-(4-(Chloro difluoromethoxy)phenyl)-6-(3-hydroxypyrrolidin-1-yl)-5-(1H-pyrazol-5-yl)nicotinamide
  • (R)-N-[4-(Chlorodifluoromethoxy)phenyl]-6-(3-hydroxy-1-pyrrolidinyl)-5-(3-pyrazolyl)nicotinamide
  • N-(4-(Chlorodifluoromethoxy)phenyl)-6-((3R)-3- hydroxypyrrolidin-1-yl)-5-(1H-pyrazol-3-yl)pyridine- 3-carboxamide
  • N-[4-(Chlorodifluoromethoxy)phenyl]-6-[(3R)-3-hydroxy-1-pyrrolidinyl]-5-(1H-pyrazol-3-yl)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
449.85 g/molcalc.
Exact mass
449.1066 Dacalc.
LogP (octanol/water)
3.46calc.
Topological polar surface area
103.4 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
6calc.
Heavy atoms
31calc.
Rings
4calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.25calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(Nc1ccccc1)c1cnc(N2CCCC2)c(-c2ccn[nH]2)c1

O=C(Nc1ccccc1)c1cnc(N2CCCC2)c(-c2ccn[nH]2)c1

4 rings, 25 atoms.

6 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Asciminib suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 16 suppliers
16 of 16 offers
  • 1st Scientific LLC
    China, NanjingUnclaimed profile
    AsciminibGrade, purity and minimum order on request
    Price on request
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  • Accela ChemBio Inc.
    United States, San DiegoUnclaimed profile
    AsciminibGrade, purity and minimum order on request
    Price on request
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  • AChemBlock
    United States, HaywardUnclaimed profile
    AsciminibGrade, purity and minimum order on request
    Price on request
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  • Acmec Biochemical
    China, ShanghaiUnclaimed profile
    AsciminibGrade, purity and minimum order on request
    Price on request
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  • Ambeed, Inc.
    United States, Buffalo GroveUnclaimed profile
    AsciminibGrade, purity and minimum order on request
    Price on request
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  • Axon Medchem
    United States, RestonUnclaimed profile
    AsciminibGrade, purity and minimum order on request
    Price on request
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  • Cangzhou Enke Pharma-tech Co., Ltd.
    China, Cangzhou ManufacturerUnclaimed profile
    AsciminibGrade, purity and minimum order on request
    Price on request
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  • ChemShuttle
    United States, BurlingameUnclaimed profile
    AsciminibGrade, purity and minimum order on request
    Price on request
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  • CYH Pharma
    China, ShanghaiUnclaimed profile
    AsciminibGrade, purity and minimum order on request
    Price on request
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  • DC Chemicals
    China, PudongUnclaimed profile
    AsciminibGrade, purity and minimum order on request
    Price on request
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

16 suppliers in 4 countries

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Asciminib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Pharmacological actions

  • Tyrosine Kinase Inhibitors

Roles

  • antineoplastic agent
  • pharmaceutical
  • protective agent
  • renoprotective agent

Pharmacology

Asciminib is a tyrosine kinase inhibitor that specifically targets myristoyl pocket of ABL1 and is used to treat refractory forms of Philadelphia chromosome positive chronic myelocytic leukemia. Serum aminotransferase elevations occur in a proportion of patients treated with asciminib, but episodes of clinically apparent liver injury with jaundice have not been reported with its use.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Asciminib is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Asciminib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Asciminib, based on the data on this page

What is Asciminib?

Asciminib is an orally bioavailable, allosteric Bcr-Abl1 tyrosine kinase inhibitor, with antineoplastic activity.

What is the CAS number of Asciminib?

The CAS registry number of Asciminib is 1492952-76-7.

What is the molecular formula and weight of Asciminib?

The molecular formula of Asciminib is C20H18ClF2N5O3 and its molar mass is 449.85 g/mol.

What is Asciminib used for?

Known uses and roles of Asciminib include anticancer drugs in pharmaceuticals, antineoplastic agent, pharmaceutical, protective agent, renoprotective agent and 1 more.

Is Asciminib hazardous?

No GHS hazard classification for Asciminib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Asciminib?

Asciminib is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Asciminib?

CompoundList lists 16 suppliers of Asciminib in China, United States, Hong Kong and Netherlands. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Asciminib?

Suppliers quote Asciminib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Asciminib

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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