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Amino acids and derivatives

Azaserine

Also known as O-Diazoacetyl-L-serine, L-azaserine, Azaserina

CAS 115-02-6Formula C5H7N3O4Molar mass 173.13 g/molEC 204-061-6
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Serious health hazard 13 suppliers listed
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Azaserine chemical structure, C5H7N3O4, CAS 115-02-6
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Orthorhombic, pale yellow to green crystals from 90% ethanol
Melting point
About 157 deg
Solubility
SLIGHTLY SOL IN METHANOL, ABSOLUTE ETHANOL ACETONE, SOL IN WARM AQ SOLN OF METHANOL, ABS…
HS code
292700
Category
Amino acids and derivatives
UN number
UN 3462
Illustrative photo, off-white crystalline powder in fibre drums in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Azaserine?

Plain description, key identifiers and synonyms

Azaserine is a carboxylic ester resulting from the formal condensation of the carboxy group of diazoacetic acid with the alcoholic hydroxy group of L-serine. An antibiotic produced by a Streptomyces species. It has a role as a glutamine antagonist, a metabolite, an antimicrobial agent, an antimetabolite, an antineoplastic agent, an immunosuppressive agent and an antifungal agent. It is a carboxylic ester, a diazo compound, a non-proteinogenic L-alpha-amino acid and a L-serine derivative.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S)-2-amino-3-(2-diazoacetyl)oxypropanoic acid
CAS number
115-02-6 CAS number cross-checked
EC number
204-061-6
Molecular formula
C5H7N3O4
UNII
87299V3Q9W
MDL number
MFCD00036802
InChIKey
MZZGOOYMKKIOOX-VKHMYHEASA-N
InChI
InChI=1S/C5H7N3O4/c6-3(5(10)11)2-12-4(9)1-8-7/h1,3H,2,6H2,(H,10,11)/t3-/m0/s1
Canonical SMILES
[N-]=[N+]=CC(=O)OCC(N)C(=O)O
Isomeric SMILES
C([C@@H](C(=O)O)N)OC(=O)C=[N+]=[N-]

Synonyms

  • O-Diazoacetyl-L-serine
  • L-azaserine
  • Azaserina
  • L-Serine, diazoacetate (ester)
  • Azaserinum
  • Diazoacetate (ester) L-serine
  • CL 337
  • L-beta-(Diazoacetoxy)alanin
  • CN-15,757
  • CN 15757
  • Serine, diazoacetate (ester), L-
  • Acetic acid, diazo-, ester with serine
  • (2S)-2-amino-3-(2-diazoacetyl)oxypropanoic acid
  • Azeserine
  • L-serine diazoacetate (ester)
  • Serine Diazoacetate
  • O Diazoacetyl L serine
  • Diazoacetic Acid Ester with Serine
  • L-Diazoacetate (ester) serine
  • (2S)-2-amino-3-((2E)-2-diazoacetyl)oxypropanoic acid
  • Diazoacetate(ester) L-serine
  • Diazoacetylserine
  • L-Diazoacetate(ester) serine
  • Azaserin
  • O-(diazoacetyl)-L-serine
Show all 34 synonyms
  • L-Serine, O-(2-diazoacetyl)-
  • RCRA waste number U015
  • (2S)-2-amino-3-[(2-diazoacetyl)oxy]propanoic acid
  • AZS
  • (2S)-2-amino-3-(2-diazoacetyl)oxy-propanoic acid
  • RCRA waste no. U015
  • CI-337, O-Diazoacetyl-L-serine, P-165
  • Asaserine
  • L-serine diazoacetate

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Orthorhombic, pale yellow to green crystals from 90% ethanolexp.
Melting point
About 157 degexp.
Solubility
SLIGHTLY SOL IN METHANOL, ABSOLUTE ETHANOL ACETONE, SOL IN WARM AQ SOLN OF METHANOL, ABSOLUTE ETHANOL ACETONEexp.
Vapour pressure
1.53 × 10⁻¹⁰ mmHg at 25 °C.exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
173.13 g/molcalc.
Exact mass
173.0437 Dacalc.
LogP (octanol/water)
-1.76calc.
Topological polar surface area
126 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
4calc.
Heavy atoms
12calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.4calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H301Toxic if swallowed.
  • H351Suspected of causing cancer.
Precautionary statements (10)
  • P203Obtain, read and follow all safety instructions before use.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 3462

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Azaserine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 13 suppliers
13 of 13 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

13 suppliers in 6 countries

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Azaserine price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

Research chemical, eg, for leukemia treatment.

Pharmacological actions

  • Antibiotics, Antineoplastic
  • Antifungal Agents
  • Antimetabolites, Antineoplastic
  • Immunosuppressive Agents

Roles

  • antagonist
  • antifungal agent
  • antimetabolite
  • antimicrobial agent
  • antineoplastic agent
  • glutamine antagonist
  • immunomodulator
  • immunosuppressive agent
  • metabolite
  • pharmaceutical

Pharmacology

Azaserine is a naturally occurring serine derivative diazo compound with antineoplastic properties, Azaserine functions as a purine antagonist and glutamine analogue (glutamine amidotransferase inhibitor) that competitively inhibits pathways in which glutamine is metabolized. An antibiotic and antitumor agent, Azaserine is used in clinical studies as a potential antineoplastic agent. (NCI04)

How it is made

Produced by a streptomyces species or by synthesis.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Azaserine is traded under.

HS 2927.00Indicative HS code

Diazo-, azo- or azoxy compounds

World exports in 2024
$571M
+6.1% vs 2023, imports $525M
2019 to 2024
Top exporters
  1. China47.0%
  2. Indonesia13.1%
  3. Japan9.3%
Top importers
  1. United States10.2%
  2. India * partner reported9.1%
  3. South Korea9.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Azaserine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Azaserine, based on the data on this page

What is Azaserine?

Azaserine is a carboxylic ester resulting from the formal condensation of the carboxy group of diazoacetic acid with the alcoholic hydroxy group of L-serine. An antibiotic produced by a Streptomyces species.

What is the CAS number of Azaserine?

The CAS registry number of Azaserine is 115-02-6.

What is the molecular formula and weight of Azaserine?

The molecular formula of Azaserine is C5H7N3O4 and its molar mass is 173.13 g/mol.

What is Azaserine used for?

Veterinary medication:. Research chemical, eg, for leukemia treatment.

Is Azaserine hazardous?

Azaserine carries the GHS signal word "Danger". Main hazards: toxic if swallowed, suspected of causing cancer. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Azaserine?

Azaserine is usually classified under HS code 292700 (Diazo-, azo- or azoxy-compounds). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Azaserine?

CompoundList lists 13 suppliers of Azaserine in China, United States, France, Hong Kong and 2 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Azaserine?

Suppliers quote Azaserine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Azaserine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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