Azilsartan (CAS 147403-03-0): price, suppliers and safety

What is Azilsartan?

Plain description, key identifiers and synonyms

Azilsartan is a benzimidazolecarboxylic acid that is benzimidazole-7-carboxylic acid substituted at position 2 by a methoxy group and at position 1 by a 2'-[(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl group. Used (as the prodrug, azilsartan medoxomil) for treatment of hypertension. It has a role as an antihypertensive agent and an angiotensin receptor antagonist. It is an aromatic ether, a benzimidazolecarboxylic acid and a 1,2,4-oxadiazole.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name: 2-ethoxy-3-[[4-[2-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid
CAS number: 147403-03-0 CAS number cross-checked
EC number: 808-058-6
Molecular formula: C₂₅H₂₀N₄O₅
UNII: F9NUX55P23
MDL number: MFCD00916395, MFCD20278186
InChIKey: KGSXMPPBFPAXLY-UHFFFAOYSA-N
InChI: InChI=1S/C25H20N4O5/c1-2-33-24-26-20-9-5-8-19(23(30)31)21(20)29(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-27-25(32)34-28-22/h3-13H,2,14H2,1H3,(H,30,31)(H,27,28,32)
SMILES (canonical and isomeric): CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NOC(=O)N5)C(=O)O

Synonyms

TAK 536
1H-Benzimidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-
2-ethoxy-3-[[4-[2-(5-oxo-2H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid
2-ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid
2-Ethoxy-1-((2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-biphenyl-4-yl)methyl)-1H-benzimidazole-7-carboxylic acid
1H-Benzimidazole-7-carboxylic acid, 1-((2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)(1,1'-biphenyl)-4-yl)methyl)-2-ethoxy-
2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzimidazole-7-carboxylic acid
2-ethoxy-3-((4-(2-(5-oxo-2H-1,2,4-oxadiazol-3-yl)phenyl)phenyl)methyl)benzimidazole-4-carboxylic acid
1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic Acid
2-ethoxy-3-[[4-[2-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid
2-ethoxy-1-((2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylic acid
2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylic acid
1H-Benzimidazole-7-carboxylic acid, 1-((2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol- 3-yl)(1,1'-biphenyl)-4-yl)methyl)-2-ethoxy-
2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylic acid
2-Ethoxy-1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid
azilsartan?
Azilva (TN)
Azilsartan (Standard)
Azilsartan Impurity 163
Azilsartan (TAK-536)
Azilsartan (JAN/USAN/INN)
Azilsartan - Bio-X trade mark
Azilsartan, >=98% (HPLC)
2-Ethoxy-1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)bi
1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl) [1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid

Show all 27 synonyms

2-Ethoxy-1-((2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzimidazole-7-carboxylic acid
2-Ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)- 1H-benzimidazole-7-carboxylic acid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance	Colorless prisms from ethanolexp.
Melting point	212 to 214exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight	456.46 g/molcalc.
Exact mass	456.1434 Dacalc.
LogP (octanol/water)	4.19calc.
Topological polar surface area	123.2 Å²calc.
Hydrogen bond donors	2calc.
Hydrogen bond acceptors	6calc.
Rotatable bonds	7calc.
Heavy atoms	34calc.
Rings	5calc.
Aromatic rings	5calc.
Fraction sp3 carbons	0.12calc.
Formal charge	0calc.
Stereocentres	0calc.
Lipinski rule of five	Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

O=c1[nH]c(-c2ccccc2-c2ccc(Cn3cnc4ccccc43)cc2)no1

5 rings, 28 atoms.

15 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word

Danger

Serious health hazard

Hazard statements

H360May damage fertility or the unborn child.
H361Suspected of damaging fertility or the unborn child.
H362May cause harm to breast-fed children.
H372Causes damage to organs through prolonged or repeated exposure.

Precautionary statements (10)

P203Obtain, read and follow all safety instructions before use.
P260Do not breathe dust, fume, gas, mist, vapours or spray.
P263Avoid contact during pregnancy and while nursing.
P264Wash skin thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves, protective clothing, eye protection and face protection.
P318If exposed or concerned, get medical advice.
P319Get medical help if you feel unwell.
P405Store locked up.
P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Azilsartan suppliers

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All 91 suppliers

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Hangzhou Pharma & Chem Co., Ltd.
China, HangzhouUnclaimed profile
AzilsartanGrade, purity and minimum order on request
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Zhuhai Rundu Pharmaceutical Co., Ltd.
China, Zhuhai ManufacturerUnclaimed profile
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Hunan Jiudian Pharmaceutical Co.,Ltd.
China, Changsha ManufacturerUnclaimed profile
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Zhejiang Tianyu Pharmaceuticals Co., Ltd.
China, Taizhou ManufacturerUnclaimed profile
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Medkem
India, Hyderabad ManufacturerUnclaimed profile
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Nifty Labs Pvt. Ltd.
India, HyderabadUnclaimed profile
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Sinoway Industrial Co., Ltd
ChinaUnclaimed profile
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Hunan Chemapi Biological Technology Co., Ltd.
China, ChangshaUnclaimed profile
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Emeishan Hongsheng Pharmceutical Co., Ltd.
China, EmeishanUnclaimed profile
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Hunan Jiudian Hongyang Pharmaceutical Co., Ltd.
China, Changsha ManufacturerUnclaimed profile
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Where suppliers are based

91 suppliers in 10 countries

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Azilsartan price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Antihypertensives in pharmaceuticals

Roles

angiotensin receptor antagonist
antagonist
antihypertensive agent
antimicrobial agent
antiviral agent
cardiovascular drug
hormone antagonist
hormone receptor modulator
hypoglycemic agent
pharmaceutical
receptor modulator

Pharmacology

Azilsartan is an Angiotensin 2 Receptor Blocker. The mechanism of action of azilsartan is as an Angiotensin 2 Type 1 Receptor Antagonist. The physiologic effect of azilsartan is by means of Decreased Blood Pressure.

How it is made

Preparation: T. Naka, Y. Inada, European Patent Office patent 0520423, eidem, United States of America patent 5243054 (1992, 1993 both to Takeda).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Azilsartan is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024

$26.7B

+15.0% vs 2023, imports $26.3B

2019 to 2024

Top exporters

Ireland26.3%
China15.7%
Singapore10.3%

Top importers

Reported customs values in USD, not prices.Full trade data

The HS code shown for Azilsartan is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Parent and salt forms, stereoisomers, similar structures and isomers

Salt and hydrate forms

Records that share this compound as their parent

Azilsartan trimethylethanolamine chemical structure, C30H33N5O6, CAS 1309776-70-2

Azilsartan trimethylethanolamine1309776-70-2C₃₀H₃₃N₅O₆

Orb1698219 chemical structure, C55H53N9O11, CAS 1824707-75-6

Orb16982191824707-75-6C₅₅H₅₃N₉O₁₁

Stereoisomers and isotopic forms

Same connectivity, different stereochemistry or isotopes (same InChIKey skeleton)

Azilsartan-d5 chemical structure, C25H20N4O5, CAS 1346599-45-8

Azilsartan-d51346599-45-8C₂₅H₂₀N₄O₅

Azilsartan-d4 chemical structure, C25H20N4O5, CAS 1794817-45-0

Azilsartan-d41794817-45-0C₂₅H₂₀N₄O₅

Similar structures

Nearest neighbours by Morgan fingerprint Tanimoto similarity

Methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-biphenyl-4-yl)methyl)-1H-benz-imidazole-7-carboxylate chemical structure, C26H22N4O5, CAS 147403-52-9

Ethyl 2-ethoxy-1-((2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate chemical structure, C27H24N4O5, CAS 1403474-70-3

Azilsartan medoxomil chemical structure, C30H24N4O8, CAS 863031-21-4

1-((2'-Cyano-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid chemical structure, C24H19N3O3, CAS 632322-61-3

O-Desethyl azilsartan chemical structure, C23H16N4O5, CAS 1442400-68-1

Candesartan chemical structure, C24H20N6O3, CAS 139481-59-7

2H-2-Ethyl candesartan chemical structure, C26H24N6O3, CAS 1246819-02-2

2-Ethoxy-1-((2'-(1-(triphenylmethyl)-1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-1H-benzimidazole-7-carboxylic acid chemical structure, C43H34N6O3, CAS 139481-72-4

Same formula isomers

Different compounds that share this molecular formula

All isomers

1-((3-(4-Methoxyphenyl)-5-(3-nitrophenyl)-4,5-dihydro-1H-pyrazol-1-yl)methyl)indoline-2,3-dione chemical structure, C25H20N4O5, CAS 331988-69-3

1-((3-(4-Methoxyphenyl)-5-(3-nitrophenyl)-4,5-dihydro-1H-pyrazol-1-yl)methyl)indoline-2,3-dione331988-69-3C₂₅H₂₀N₄O₅

1-(2-(2-Pyrazinylcarbonyl)carbohydrazonoyl)-2-naphthyl 3,4-dimethoxybenzoate chemical structure, C25H20N4O5, CAS 764653-43-2

1-(2-(2-Pyrazinylcarbonyl)carbohydrazonoyl)-2-naphthyl 3,4-dimethoxybenzoate764653-43-2C₂₅H₂₀N₄O₅

3-(3,5-Dimethoxyphenyl)-1-((4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl)quinazoline-2,4(1H,3H)-dione chemical structure, C25H20N4O5, CAS 892264-61-8

3-(3,5-Dimethoxyphenyl)-1-((4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl)quinazoline-2,4(1H,3H)-dione892264-61-8C₂₅H₂₀N₄O₅

3-(2,4-Dimethoxyphenyl)-1-((4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl)quinazoline-2,4(1H,3H)-dione chemical structure, C25H20N4O5, CAS 1023866-70-7

3-(2,4-Dimethoxyphenyl)-1-((4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl)quinazoline-2,4(1H,3H)-dione1023866-70-7C₂₅H₂₀N₄O₅

Ethyl 4-[[3-(4-nitrophenyl)-1-phenylpyrazole-4-carbonyl]amino]benzoate chemical structure, C25H20N4O5, CAS 882229-58-5

Ethyl 4-[[3-(4-nitrophenyl)-1-phenylpyrazole-4-carbonyl]amino]benzoate882229-58-5C₂₅H₂₀N₄O₅

8-Ethoxy-N-(3-(6-methoxyimidazo[1,2-b]pyridazin-2-yl)phenyl)-2-oxo-2H-chromene-3-carboxamide chemical structure, C25H20N4O5, CAS 953240-94-3

8-Ethoxy-N-(3-(6-methoxyimidazo[1,2-b]pyridazin-2-yl)phenyl)-2-oxo-2H-chromene-3-carboxamide953240-94-3C₂₅H₂₀N₄O₅

N-(2-Ethoxyphenyl)-3-hydroxy-4-(2-(2-nitrophenyl)diazenyl)-2-naphthalenecarboxamide chemical structure, C25H20N4O5, CAS 94199-57-2

N-(2-Ethoxyphenyl)-3-hydroxy-4-(2-(2-nitrophenyl)diazenyl)-2-naphthalenecarboxamide94199-57-2C₂₅H₂₀N₄O₅

N-[(E)-[4-Methoxy-3-(quinolin-8-yloxymethyl)phenyl]methylideneamino]-3-nitrobenzamide chemical structure, C25H20N4O5, CAS 514855-40-4

N-[(E)-[4-Methoxy-3-(quinolin-8-yloxymethyl)phenyl]methylideneamino]-3-nitrobenzamide514855-40-4C₂₅H₂₀N₄O₅

4-[3-(3,4-Dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-2-(4-methoxyphenyl)phthalazin-1(2H)-one chemical structure, C25H20N4O5, CAS 1207044-66-3

4-[3-(3,4-Dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-2-(4-methoxyphenyl)phthalazin-1(2H)-one1207044-66-3C₂₅H₂₀N₄O₅

4-[3-(3,5-Dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-2-(4-methoxyphenyl)phthalazin-1(2H)-one chemical structure, C25H20N4O5, CAS 1207059-18-4

4-[3-(3,5-Dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-2-(4-methoxyphenyl)phthalazin-1(2H)-one1207059-18-4C₂₅H₂₀N₄O₅

3-(Benzo[d][1,3]dioxol-5-ylmethyl)-1-(2-(indolin-1-yl)-2-oxoethyl)pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione chemical structure, C25H20N4O5, CAS 923244-50-2

3-(Benzo[d][1,3]dioxol-5-ylmethyl)-1-(2-(indolin-1-yl)-2-oxoethyl)pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione923244-50-2C₂₅H₂₀N₄O₅

2-Phenyl-4-[3-(3,4,5-trimethoxyphenyl)-1,2,4-oxadiazol-5-yl]phthalazin-1(2H)-one chemical structure, C25H20N4O5, CAS 1206984-91-9

2-Phenyl-4-[3-(3,4,5-trimethoxyphenyl)-1,2,4-oxadiazol-5-yl]phthalazin-1(2H)-one1206984-91-9C₂₅H₂₀N₄O₅

Frequently asked questions

Quick answers about Azilsartan, based on the data on this page

What is Azilsartan?

Azilsartan is a benzimidazolecarboxylic acid that is benzimidazole-7-carboxylic acid substituted at position 2 by a methoxy group and at position 1 by a 2'-[(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl group. Used (as the prodrug, azilsartan medoxomil) for treatment of hypertension.

What is the CAS number of Azilsartan?

The CAS registry number of Azilsartan is 147403-03-0.

What is the molecular formula and weight of Azilsartan?

The molecular formula of Azilsartan is C25H20N4O5 and its molar mass is 456.46 g/mol.

What is Azilsartan used for?

Known uses and roles of Azilsartan include antihypertensives in pharmaceuticals, angiotensin receptor antagonist, antagonist, antihypertensive agent, antimicrobial agent and 7 more.

Is Azilsartan hazardous?

Azilsartan carries the GHS signal word "Danger". Main hazards: may damage fertility or the unborn child, suspected of damaging fertility or the unborn child, may cause harm to breast-fed children. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Azilsartan?

Azilsartan is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Azilsartan?

CompoundList lists 91 suppliers of Azilsartan in China, United States, India, Japan and 6 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Azilsartan in India?

13 suppliers in India list Azilsartan on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Azilsartan?

Suppliers quote Azilsartan on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Azilsartan

Azilsartan

Key facts

What is Azilsartan?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Murcko scaffold

Safety and hazards

Hazard statements

Azilsartan suppliers

Where suppliers are based

Send one request to many suppliers

Azilsartan price

Uses and applications

Industries and functions

Roles

Pharmacology

How it is made

Regulatory status

Health and food

HS code and trade data

Global trade

Frequently asked questions

What is Azilsartan?

What is the CAS number of Azilsartan?

What is the molecular formula and weight of Azilsartan?

What is Azilsartan used for?

Is Azilsartan hazardous?

What is the HS code of Azilsartan?

Where can I buy Azilsartan?

Where can I buy Azilsartan in India?

What is the price of Azilsartan?

Guides for buyers

Get quotes for Azilsartan

Key facts

What is Azilsartan?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Murcko scaffold

Safety and hazards

Hazard statements

Azilsartan suppliers

Where suppliers are based

Send one request to many suppliers

Azilsartan price

Uses and applications

Industries and functions

Roles

Pharmacology

How it is made

Regulatory status

Health and food

HS code and trade data

Global trade

Related chemicals

Salt and hydrate forms

Stereoisomers and isotopic forms

Similar structures

Same formula isomers

Frequently asked questions

What is Azilsartan?

What is the CAS number of Azilsartan?

What is the molecular formula and weight of Azilsartan?

What is Azilsartan used for?

Is Azilsartan hazardous?

What is the HS code of Azilsartan?

Where can I buy Azilsartan?

Where can I buy Azilsartan in India?

What is the price of Azilsartan?

Guides for buyers

Get quotes for Azilsartan