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Analgesics and anti-inflammatories

Binimetinib

Also known as ARRY-162, Mektovi, 5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide

CAS 606143-89-9Formula C17H15BrF2N4O3Molar mass 441.23 g/molEC 639-995-7
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Binimetinib chemical structure, C17H15BrF2N4O3, CAS 606143-89-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
606143-89-9
Formula
C17H15BrF2N4O3
Molar mass
441.23 g/mol
EC number
639-995-7
HS code
293399
Category
Analgesics and anti-inflammatories

What is Binimetinib?

Plain description, key identifiers and synonyms

Binimetinib is a member of the class of benzimidazoles that is 1-methyl-1H-benzimidazole which is substituted at positions 4, 5, and 6 by fluorine, (4-bromo-2-fluorophenyl)nitrilo, and N-(2-hydroxyethoxy)aminocarbonyl groups, respectively. It is a MEK1 and MEK2 inhibitor (IC50= 12 nM). Approved by the FDA for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation in combination with encorafenib. It has a role as an antineoplastic agent, an apoptosis inducer and an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor. It is a member of benzimidazoles, a member of bromobenzenes, a secondary amino compound, a hydroxamic acid ester and a member of monofluorobenzenes.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
6-(4-bromo-2-fluoroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
CAS number
606143-89-9 CAS number cross-checkedOther or deprecated CAS: 1073666-70-2
EC number
639-995-7
Molecular formula
C17H15BrF2N4O3
UNII
181R97MR71
MDL number
MFCD22124525
InChIKey
ACWZRVQXLIRSDF-UHFFFAOYSA-N
InChI
InChI=1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
SMILES (canonical and isomeric)
CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO

Synonyms

  • ARRY-162
  • Mektovi
  • 5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
  • ARRY 438162
  • binimetinibum
  • 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-1,3-benzodiazole-6-carboxamide
  • 6-[(4-bromo-2-fluorophenyl)amino]-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
  • 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-1,3-benzodiazole-6-carboxamide
  • 5-((4-Bromo-2-fluorophenyl)amino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
  • 6-((4-bromo-2-fluorophenyl)amino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
  • ARRY 162
  • Binimetinib (MEK-162)
  • 6-(4-bromo-2-fluoroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
  • MEK162 (ARRY-162, ARRY-438162)
  • 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzo[d]imidazole-6-carboxamide
  • 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzo[d]imidazole-6-carboxamide.
  • Binimetinib (MEK162, ARRY-162, ARRY-438162)
  • US11147816, Binimetinib (ARRY-162, ARRY-438162)
  • 5-(4-Bromo-2-fluoroanilino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
  • C17H15BrF2N4O3
  • Binimetinib (MEK162)
  • Mektovi (TN)
  • ARRY-162, ARRY-438162, MEK 162, ARRY 162, ARRY 438162
  • Binimetinib, Mek162
  • Binimetinib (Standard)
Show all 29 synonyms
  • MEK162(Binimetinib)
  • MEK162(Binimetinib)?
  • 6-(4-bromo-2-fluoroan
  • Binimetinib (JAN/USAN/INN)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
441.23 g/molcalc.
Exact mass
440.0296 Dacalc.
LogP (octanol/water)
3.01calc.
Topological polar surface area
88.41 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
6calc.
Heavy atoms
27calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.18calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(Nc2ccc3[nH]cnc3c2)cc1

c1ccc(Nc2ccc3[nH]cnc3c2)cc1

3 rings, 16 atoms, the N-Phenyl-1H-benzo[d]imidazol-5-amine ring system.

44 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Binimetinib suppliers

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All 59 suppliers
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Where suppliers are based

59 suppliers in 13 countries

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Binimetinib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • antirheumatic drug
  • apoptosis inducer
  • enzyme inhibitor
  • pharmaceutical
  • protein kinase inhibitor

Pharmacology

Binimetinib is an orally available inhibitor of mitogen-activated protein kinase kinase 1 and 2 (MEK1/2) with potential antineoplastic activity. Binimetinib, noncompetitive with ATP, binds to and inhibits the activity of MEK1/2. Inhibition of MEK1/2 prevents the activation of MEK1/2 dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling. This may eventually lead to an inhibition of tumor cell proliferation and an inhibition in production of various inflammatory cytokines including interleukin-1, -6 and tumor necrosis factor. MEK1/2 are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Binimetinib is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Binimetinib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Binimetinib, based on the data on this page

What is Binimetinib?

Binimetinib is a member of the class of benzimidazoles that is 1-methyl-1H-benzimidazole which is substituted at positions 4, 5, and 6 by fluorine, (4-bromo-2-fluorophenyl)nitrilo, and N-(2-hydroxyethoxy)aminocarbonyl groups, respectively. It is a MEK1 and MEK2 inhibitor (IC50= 12 nM).

What is the CAS number of Binimetinib?

The CAS registry number of Binimetinib is 606143-89-9. Other or deprecated CAS numbers: 1073666-70-2.

What is the molecular formula and weight of Binimetinib?

The molecular formula of Binimetinib is C17H15BrF2N4O3 and its molar mass is 441.23 g/mol.

What is Binimetinib used for?

Known uses and roles of Binimetinib include anti-inflammatories in pharmaceuticals, antineoplastic agent, antirheumatic drug, apoptosis inducer, enzyme inhibitor and 2 more.

Is Binimetinib hazardous?

No GHS hazard classification for Binimetinib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Binimetinib?

Binimetinib is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Binimetinib?

CompoundList lists 59 suppliers of Binimetinib in China, United States, India, Hong Kong and 9 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Binimetinib in India?

3 suppliers in India list Binimetinib on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Binimetinib?

Suppliers quote Binimetinib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Binimetinib

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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