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Vitamins and nutraceutical actives

Biotin

Also known as d-biotin, vitamin H, Vitamin B7

CAS 58-85-5Formula C10H16N2O3SMolar mass 244.32 g/molEC 200-399-3
334 suppliers listed Drug substance
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Biotin chemical structure, C10H16N2O3S, CAS 58-85-5
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Long, thin needles from water
Melting point
232 °C
Solubility
HIGHLY SOL IN WATER /SODIUM SALT/
HS code
293629
Category
Vitamins and nutraceutical actives
Illustrative photo, closed white HDPE bottles and amber jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Biotin?

Plain description, key identifiers and synonyms

Biotin is an organic heterobicyclic compound that consists of 2-oxohexahydro-1H-thieno[3,4-d]imidazole having a valeric acid substituent attached to the tetrahydrothiophene ring. The parent of the class of biotins. It has a role as a coenzyme, a cofactor, a prosthetic group, a nutraceutical, a mouse metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a human metabolite and a fundamental metabolite. It is a vitamin B7 and a member of biotins. It is a conjugate acid of a biotinate.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoic acid
CAS number
58-85-5 CAS number cross-checkedOther or deprecated CAS: 22377-59-9, 56846-45-8
EC number
200-399-3
Molecular formula
C10H16N2O3S
UNII
6SO6U10H04
MDL number
MFCD00005541
INCI name
BIOTIN
InChIKey
YBJHBAHKTGYVGT-ZKWXMUAHSA-N
InChI
InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1
Canonical SMILES
O=C(O)CCCCC1SCC2NC(=O)NC21
Isomeric SMILES
C1[C@H]2[C@@H]([C@@H](S1)CCCCC(=O)O)NC(=O)N2

Synonyms

  • d-biotin
  • vitamin H
  • Vitamin B7
  • Bioepiderm
  • coenzyme R
  • Factor S
  • Bios II
  • D(+)-Biotin
  • D-(+)-Biotin
  • (+)-Biotin
  • Biotine
  • Biotina
  • Factor S (vitamin)
  • Injacom H
  • Biotinum
  • Vitamin Bw
  • Ritatin
  • 1H-thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS,4S,6aR)-
  • 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoic acid
  • 5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid
  • cis-Hexahydro-2-oxo-1H-thieno(3,4)imidazole-4-valeric acid
  • cis-Tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid
  • 5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid
  • 1H-Thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS-(3aalpha,4beta,6aalpha))-
  • 2'-Keto-3,4-imidazolido-2-tetrahydrothiophene-N-valeric acid
Show all 39 synonyms
  • cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valeric acid
  • (+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid
  • (3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno(3,4-d)imidazole-4-valeric acid
  • 5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl]pentanoic acid
  • (3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-valeric acid
  • Hexahydro-2-oxo-1H-thieno(3,4-d)imidazole-4-pentanoic acid
  • Gelfert, Biotin
  • Biotin ratiopharm
  • Hermes, Biotin
  • Roche, Biotine
  • 1H-Thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS,4S,6aR)-
  • hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic acid
  • Biotitum
  • cis-(+)-Tetrahydro-2-oxothieno(3,4)imidazoline-4-valeric acid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Long, thin needles from waterexp.
Melting point
232 °Cexp.
Solubility
HIGHLY SOL IN WATER /SODIUM SALT/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
244.32 g/molcalc.
Exact mass
244.0882 Dacalc.
LogP (octanol/water)
0.8calc.
Topological polar surface area
78.43 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
5calc.
Heavy atoms
16calc.
Rings
2calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.8calc.
Formal charge
0calc.
Stereocentres
3calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1NC2CSCC2N1

O=C1NC2CSCC2N1

2 rings, 9 atoms.

443 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS classification
Hazard pictograms

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Biotin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 334 suppliers
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Where suppliers are based

334 suppliers in 42 countries

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Biotin price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Recommended for first-line treatment of weak, brittle, splitting, or soft nails (Appearex).

Veterinary medication:.

Biotin functions as a hair-conditioning agent and a skin-conditioning agent--miscellaneous. The product formulation data submitted to the Food and Drug Administration (FDA) in 1998 stated that biotin was contained in a total of 71 cosmetic product formulations.

Biotin is generally recognized as safe as a dietary supplement, as a nutrient, and in animal feed. Its functional use in food is as a nutrient and dietary supplement.

Use classes: Cosmetics.

Cosmetic ingredient, INCI name BIOTIN(hair conditioning, skin conditioning - miscellaneous)

Pharmacological actions

  • Vitamin B Complex

Roles

  • Escherichia coli metabolite
  • Saccharomyces cerevisiae metabolite
  • animal metabolite
  • anti-anaemic agent
  • anti-asthmatic agent
  • bacterial metabolite
  • cardiovascular drug
  • coenzyme
  • cofactor
  • eukaryotic metabolite
  • fundamental metabolite
  • fungal metabolite
  • human metabolite
  • hypoglycemic agent
  • immunomodulator
  • immunosuppressive agent
  • metabolite
  • mouse metabolite
  • nutraceutical
  • pharmaceutical
  • prokaryotic metabolite
  • prosthetic group
  • protective agent
  • renoprotective agent

Functional uses

  • Chelating agent
  • Flavouring and nutrient
  • Pharmaceutical
  • Softener and conditioner

Cosmetic functions

  • Hair conditioning
  • Skin conditioning - miscellaneous

Pharmacology

Biotin is hexahydro-2-oxo-1H-thieno(3,4-d)imidazole-4-pentanoic acid. Growth factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk. The biotin content of cancerous tissue is higher than that of normal tissue.

How it is made

Isolated from liver, kidney, yeast, and cows' milk by acidic or enzymatic hydrolysis, synthesized from a meso-diaminosuccinic acid derivative

The Hoffman-La Roche industrial synthesis of biotin starts with fumaric acid. The sequence of bromination, replacement of dibromide with benzyl-bromide, and ring closure with phosgene gives the imidazole cis-dicarboxylic acid. The corresponding anhydride is opened with cyclohexanol to the racemic monoester which is resolved with (+)-ephedrine in high yield. The enantiomer is recycled back to the anhydride.

Read more

Lithium borohydride reduces only the ester group of (+)-ephedrine, thus producing the lactone with the desired absolute configuration. Sulfur is then introduced by treatment with potassium thioacetate to give the thiolactone. The side chain is introduced in two phases. The first three carbons are attached by a Grignard reaction. Dehydration and hydrogenation over Raney nickel establishes the third chiral center stereospecifically. The last two carbons are then added by reaction of the cyclic sulfonium cation with sodium dimethylmalonate. Hydrolysis of the ester groups of decarboxylation, and didebenzylation occur during heating with aqueous HBr to produce the optically pure biotin in a more than 25% overall yield.

Sumitomo produces biotin by an efficient asymmetric conversion of the prochiral cis-acid to the optically active lactone. The acid reacts with the optically active dihydroxy amine to give quantitatively the chiral imide.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Biotin is traded under.

HS 2936.29Indicative HS code

Vitamins and their derivatives, unmixed, other vitamins and their derivatives

World exports in 2024
$2.21B
+8.7% vs 2023, imports $1.85B
2019 to 2024
Top exporters
  1. China25.3%
  2. United States14.5%
  3. Australia13.8%
Top importers
  1. United States16.4%
  2. Netherlands9.4%
  3. Spain5.6%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Biotin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Biotin, based on the data on this page

What is Biotin?

Biotin is an organic heterobicyclic compound that consists of 2-oxohexahydro-1H-thieno[3,4-d]imidazole having a valeric acid substituent attached to the tetrahydrothiophene ring. The parent of the class of biotins.

What is the CAS number of Biotin?

The CAS registry number of Biotin is 58-85-5. Other or deprecated CAS numbers: 22377-59-9, 56846-45-8.

What is the molecular formula and weight of Biotin?

The molecular formula of Biotin is C10H16N2O3S and its molar mass is 244.32 g/mol.

What is Biotin used for?

Recommended for first-line treatment of weak, brittle, splitting, or soft nails (Appearex). Veterinary medication:. Biotin functions as a hair-conditioning agent and a skin-conditioning agent--miscellaneous.

Is Biotin hazardous?

No GHS hazard classification for Biotin is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Biotin?

Biotin is usually classified under HS code 293629 (Vitamins and their derivatives, unmixed, other vitamins and their derivatives). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Biotin?

CompoundList lists 334 suppliers of Biotin in China, United States, India, Germany and 38 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Biotin in India?

52 suppliers in India list Biotin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Biotin?

Suppliers quote Biotin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Biotin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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