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Antibiotics and anti-infectives

Bithionol

Also known as Bithin, Lorothidol, 2,2'-Thiobis(4,6-dichlorophenol)

CAS 97-18-7Formula C12H6Cl4O2SMolar mass 356.06 g/molEC 202-565-0
GHS signal word: Danger. Pictograms: Acute toxicity (severe) 21 suppliers listed
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Bithionol chemical structure, C12H6Cl4O2S, CAS 97-18-7
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
White or grayish-white, crystalline powder
Melting point
188 °C
Density
1.73 at 25 °C/4 °C
Solubility
In water, 4 mg/L at 25 °C
HS code
293090
Category
Antibiotics and anti-infectives
UN number
UN 2811
Illustrative photo, off-white powder in an open kraft paper sack in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Bithionol?

Plain description, key identifiers and synonyms

Bithionol is an aryl sulfide that is diphenyl sulfide in which each phenyl group is substituted at position 2 by hydroxy and at positions 3 and 5 by chlorine. A fungicide and anthelmintic, it was used in various topical drug products for the treatment of liver flukes, but withdrawn after being shown to be a potent photosensitizer with the potential to cause serious skin disorders. It has a role as an antiplatyhelmintic drug and an antifungal agrochemical. It is a dichlorobenzene, a polyphenol, an aryl sulfide, an organochlorine pesticide, a bridged diphenyl fungicide and a bridged diphenyl antifungal drug.

Bithionol is an antiseptic additive in soaps.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2,4-dichloro-6-(3,5-dichloro-2-hydroxyphenyl)sulfanylphenol
CAS number
97-18-7 CAS number cross-checkedOther or deprecated CAS: 1394-04-3
EC number
202-565-0
Molecular formula
C12H6Cl4O2S
UNII
AMT77LS62O
MDL number
MFCD00055727
InChIKey
JFIOVJDNOJYLKP-UHFFFAOYSA-N
InChI
InChI=1S/C12H6Cl4O2S/c13-5-1-7(15)11(17)9(3-5)19-10-4-6(14)2-8(16)12(10)18/h1-4,17-18H
SMILES (canonical and isomeric)
C1=C(C=C(C(=C1SC2=C(C(=CC(=C2)Cl)Cl)O)O)Cl)Cl

Synonyms

  • Bithin
  • Lorothidol
  • 2,2'-Thiobis(4,6-dichlorophenol)
  • Actamer
  • Bitionol
  • Bidiphen
  • Bisoxyphen
  • Lorothiodol
  • Bithionol sulfide
  • Bithionolate
  • Neopellis
  • Bitin
  • Vancide BL
  • TKhsd
  • Usaf B-22
  • 2-Hydroxy-3,5-dichlorophenyl sulfide
  • Bithionolum
  • Bis(2-hydroxy-3,5-dichlorophenyl) sulfide
  • Bis(3,5-dichloro-2-hydroxyphenyl) sulfide
  • 2,2'-sulfanediylbis(4,6-dichlorophenol)
  • 2-Hydroxy-3,5-dichlorophenyl sulphide
  • 2,4-dichloro-6-(3,5-dichloro-2-hydroxyphenyl)sulfanylphenol
  • 2,2'-Dihydroxy-3,3',5,5'-tetrachlorodiphenyl sulfide
  • CP 3438
  • 2,2'-Thiobis[4,6-dichlorophenol]
Show all 36 synonyms
  • 2,2'-Dihydroxy-3,3',5,5'-tetrachlorodiphenylsulfide
  • Phenol, 2,2'-thiobis(4,6-dichloro-
  • Phenol, 2,2'-thiobis[4,6-dichloro-
  • Phenol, 2,2'-thiobis(4,6-dichloro)-
  • Nobacter
  • Bithional
  • 6,6'-thiobis(2,4-dichlorophenol)
  • XL 7
  • 2,4-dichloro-6-(3,5-dichloro-2-hydroxy-phenyl)sulfanyl-phenol
  • Xerosin
  • Phenol,2'-thiobis[4,6-dichloro-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White or grayish-white, crystalline powderexp.
Odour
Odorless or with slight aromatic or phenolic odorexp.
Melting point
188 °Cexp.
Density
1.73 at 25 °C/4 °Cexp.
Solubility
In water, 4 mg/L at 25 °Cexp.
Vapour pressure
1.1 × 10⁻⁹ mm Hg at 37 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
356.06 g/molcalc.
Exact mass
353.8843 Dacalc.
LogP (octanol/water)
5.86calc.
Topological polar surface area
40.46 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
2calc.
Heavy atoms
19calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(Sc2ccccc2)cc1

c1ccc(Sc2ccccc2)cc1

2 rings, 13 atoms, the Diphenyl sulfide ring system.

1,872 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H300Fatal if swallowed.
Precautionary statements (7)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 2811

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Bithionol suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 21 suppliers
21 of 21 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

21 suppliers in 7 countries

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Bithionol price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Surfactant-formulated antimicrobial against bacteria, molds and yeast.

Bacteriostat for cosmetics, fungicide.

Vancide BL is a germicide used in cosmetics (former use), polishes, and for algae control.

Has been used as a soap additive (Former).

Pharmacological actions

  • Anti-Infective Agents, Local
  • Antiplatyhelmintic Agents

Roles

  • agrochemical
  • anthelminthic drug
  • antifungal agent
  • antifungal agrochemical
  • antiinfective agent
  • antimicrobial agent
  • antiparasitic agent
  • antiplatyhelmintic drug
  • fungicide
  • pesticide
  • pharmaceutical

How it is made

Prepn from 2,4-halo substituted phenol with sulfur halides: ... German patent 583055 (1933 to I.G. Farbenind), ... US patent 2,849,494 (1958 to Monsanto).

/From bithionol/ sulfoxide ... obtained by the reaction of 2,4-dichlorophenol with ... (thionyl) chloride in presence of aluminium chloride: zinc-dust

Sodium salt ... Harvey et al.,US patent 3024163 (1962 to Vanderbilt Co). (Sodium salt)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Bithionol (INN), Ref no: 352, Annex ref: II/352

United States

  • TSCA inventory (USA)
    Status: Inactive in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Bithionol is traded under.

HS 2930.90Indicative HS code

Organo-sulphur compounds, other

World exports in 2024
$5.83B
+0.1% vs 2023, imports $5.93B
2019 to 2024
Top exporters
  1. China40.7%
  2. United States10.9%
  3. Japan9.3%
Top importers
  1. United States13.3%
  2. Brazil12.6%
  3. China6.6%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Bithionol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Bithionol, based on the data on this page

What is Bithionol?

Bithionol is an aryl sulfide that is diphenyl sulfide in which each phenyl group is substituted at position 2 by hydroxy and at positions 3 and 5 by chlorine.

What is the CAS number of Bithionol?

The CAS registry number of Bithionol is 97-18-7. Other or deprecated CAS numbers: 1394-04-3.

What is the molecular formula and weight of Bithionol?

The molecular formula of Bithionol is C12H6Cl4O2S and its molar mass is 356.06 g/mol.

What is Bithionol used for?

Surfactant-formulated antimicrobial against bacteria, molds and yeast. Bacteriostat for cosmetics, fungicide. Vancide BL is a germicide used in cosmetics (former use), polishes, and for algae control. Has been used as a soap additive (Former).

Is Bithionol hazardous?

Bithionol carries the GHS signal word "Danger". Main hazards: fatal if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Bithionol?

Bithionol is usually classified under HS code 293090 (Organo-sulphur compounds, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Bithionol?

CompoundList lists 21 suppliers of Bithionol in United States, China, Germany, United Kingdom and 3 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Bithionol?

Suppliers quote Bithionol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Bithionol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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