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Respiratory, allergy and digestive drugs

Bitolterol

Also known as Bitolterolum, Benzoic acid, 4-methyl-, 4-(2-((1,1-dimethylethyl)amino)-1-hydroxyethyl)-1,2-phenylene ester, 4-(2-(tert-butylamino)-1-hydroxyethyl)-o-phenylene di-p-toluate

CAS 30392-40-6Formula C28H31NO5Molar mass 461.56 g/mol
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Bitolterol chemical structure, C28H31NO5, CAS 30392-40-6
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
30392-40-6
Formula
C28H31NO5
Molar mass
461.56 g/mol
HS code
292250
Category
Respiratory, allergy and digestive drugs

What is Bitolterol?

Plain description, key identifiers and synonyms

Bitolterol is the di-4-toluate ester of (+-)-N-tert-butylnoradrenaline (colterol). A pro-drug for colterol, a beta2-adrenergic receptor agonist, bitolterol is used as its methanesulfonate salt for relief of bronchospasm in conditions such as asthma, chronic bronchitis and emphysema. It has a role as a beta-adrenergic agonist, a bronchodilator agent, an anti-asthmatic drug and a prodrug. It is a member of ethanolamines, a carboxylic ester, a secondary alcohol, a secondary amino compound and a diester.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
[4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(4-methylbenzoyl)oxyphenyl] 4-methylbenzoate
CAS number
30392-40-6 CAS number cross-checked
Molecular formula
C28H31NO5
UNII
9KY0QXD6LI
InChIKey
FZGVEKPRDOIXJY-UHFFFAOYSA-N
InChI
InChI=1S/C28H31NO5/c1-18-6-10-20(11-7-18)26(31)33-24-15-14-22(23(30)17-29-28(3,4)5)16-25(24)34-27(32)21-12-8-19(2)9-13-21/h6-16,23,29-30H,17H2,1-5H3
SMILES (canonical and isomeric)
CC1=CC=C(C=C1)C(=O)OC2=C(C=C(C=C2)C(CNC(C)(C)C)O)OC(=O)C3=CC=C(C=C3)C

Synonyms

  • Bitolterolum
  • Benzoic acid, 4-methyl-, 4-(2-((1,1-dimethylethyl)amino)-1-hydroxyethyl)-1,2-phenylene ester
  • 4-(2-(tert-butylamino)-1-hydroxyethyl)-o-phenylene di-p-toluate
  • 4-[2-(tert-Butylamino)-1-hydroxyethyl]-o-phenylene di-p-toluate
  • bis(4-methylbenzoic acid) 4-[2-(tert-butylamino)-1-hydroxyethyl]-1,2-phenylene ester
  • bitolterolo
  • bis(4-methylbenzoic acid) 4-(2-(tert-butylamino)-1-hydroxyethyl)-1,2-phenylene ester
  • 5-(2-(tert-butylamino)-1-hydroxyethyl)-2-(4-methylbenzoyloxy)phenyl 4-methylbenzoate
  • [4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(4-methylbenzoyl)oxyphenyl] 4-methylbenzoate
  • WIN 32784
  • Bitolterol (INN)
  • Benzoic acid, 4-methyl-, 1,1'-[4-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-1,2-phenylene] ester
  • 4-(2-(tert-butylamino)-1-hydroxyethyl)-1,2-phenylene bis(4-methylbenzoate)
  • p-Toluic acid, 4-[2-(tert-butylamino)-1-hydroxyethyl]-o-phenylene ester, S 1540
  • Bitolterol-API
  • 4-[2-(tert-Butylamino)-1-hydroxyethyl]-1,2-phenylene bis(4-methylbenzoate)
  • 4-(2-(tert-Butylamino)-1-hydroxyethyl-o-phenylene di-p-toluate
  • 4-(2-(tert-Butylamino)-1-hydroxyethyl-1,2-phenylen di-4-toluat
  • alpha((tert-butylamino)methyl)-3,4-dihydroxybenzyl alcohol 3,4-di-p-toluate
  • 4-[2-(tert-Butylamino)-1-hydroxyethyl]-2-[(4-methylbenzoyl)oxy]phenyl 4-methylbenzoate #
  • 4-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,2-diyl bis(4-methylbenzoate)
  • 4-{2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl}benzene-1,2-diyl bis(4-methylbenzoate)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
461.56 g/molcalc.
Exact mass
461.2202 Dacalc.
LogP (octanol/water)
5.16calc.
Topological polar surface area
84.86 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
7calc.
Heavy atoms
34calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.29calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(Oc1ccccc1OC(=O)c1ccccc1)c1ccccc1

O=C(Oc1ccccc1OC(=O)c1ccccc1)c1ccccc1

3 rings, 24 atoms, the o-Phenylene dibenzoate ring system.

19 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Bitolterol suppliers

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Bitolterol price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Adrenergic beta-2 Receptor Agonists
  • Bronchodilator Agents

Roles

  • adrenergic agent
  • adrenergic agonist
  • anti-asthmatic agent
  • anti-asthmatic drug
  • beta-adrenergic agonist
  • beta-adrenergic drug
  • bronchodilator agent
  • neurotransmitter agent
  • pharmaceutical
  • pro-agent
  • prodrug

Pharmacology

Bitolterol is a diester sympathomimetic amine with bronchodilator activity. As an ester prodrug, bitolterol is hydrolyzed by esterases to its active metabolite colterol (N-t-butylarterenol). Colterol selectively binds to and activates beta-2 adrenergic receptors in bronchiolar smooth muscle, thereby causing stimulation of adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased intracellular cAMP levels cause relaxation of bronchial smooth muscle. This increases air flow and prevents bronchospasms and may eventually lead to an improvement of airway function.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Bitolterol is traded under.

HS 2922.50Indicative HS code

Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function

World exports in 2024
$3.29B
−5.9% vs 2023, imports $3.19B
2019 to 2024
Top exporters
  1. China39.2%
  2. United Kingdom27.1%
  3. India * partner reported4.8%
Top importers
  1. United States20.7%
  2. Germany7.6%
  3. Italy6.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Bitolterol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Bitolterol, based on the data on this page

What is Bitolterol?

Bitolterol is the di-4-toluate ester of (+-)-N-tert-butylnoradrenaline (colterol). A pro-drug for colterol, a beta2-adrenergic receptor agonist, bitolterol is used as its methanesulfonate salt for relief of bronchospasm in conditions such as asthma, chronic bronchitis and emphysema.

What is the CAS number of Bitolterol?

The CAS registry number of Bitolterol is 30392-40-6.

What is the molecular formula and weight of Bitolterol?

The molecular formula of Bitolterol is C28H31NO5 and its molar mass is 461.56 g/mol.

What is Bitolterol used for?

Known uses and roles of Bitolterol include respiratory and anti-allergy drugs in pharmaceuticals, adrenergic agent, adrenergic agonist, anti-asthmatic agent, anti-asthmatic drug and 9 more.

Is Bitolterol hazardous?

No GHS hazard classification for Bitolterol is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Bitolterol?

Bitolterol is usually classified under HS code 292250 (Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Bitolterol?

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What is the price of Bitolterol?

Suppliers quote Bitolterol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Bitolterol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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