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Analgesics and anti-inflammatories

Butorphanol

Also known as Butorfanol, (-)-butorphanol, levo-BC-2627

CAS 42408-82-2Formula C21H29NO2Molar mass 327.47 g/molEC 255-808-8
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 15 suppliers listed Drug substance
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Butorphanol chemical structure, C21H29NO2, CAS 42408-82-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
42408-82-2
Formula
C21H29NO2
Molar mass
327.47 g/mol
EC number
255-808-8
HS code
293399
Category
Analgesics and anti-inflammatories

What is Butorphanol?

Plain description, key identifiers and synonyms

Butorphanol is levorphanol in which a hydrogen at position 14 of the morphinan skeleton is substituted by hydroxy and one of the hydrogens of the N-methyl group is substituted by cyclopropyl. A semi-synthetic opioid agonist-antagonist analgesic, it is used as its (S,S)-tartaric acid salt for relief or moderate to severe pain. It has a role as an opioid analgesic, an antitussive, a mu-opioid receptor agonist and a kappa-opioid receptor agonist.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(1S,9R,10S)-17-(cyclobutylmethyl)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-triene-4,10-diol
CAS number
42408-82-2 CAS number cross-checkedOther or deprecated CAS: 58115-67-6
EC number
255-808-8
Molecular formula
C21H29NO2
UNII
QV897JC36D
InChIKey
IFKLAQQSCNILHL-QHAWAJNXSA-N
InChI
InChI=1S/C21H29NO2/c23-17-7-6-16-12-19-21(24)9-2-1-8-20(21,18(16)13-17)10-11-22(19)14-15-4-3-5-15/h6-7,13,15,19,23-24H,1-5,8-12,14H2/t19-,20+,21-/m1/s1
Canonical SMILES
Oc1ccc2c(c1)C13CCCCC1(O)C(C2)N(CC1CCC1)CC3
Isomeric SMILES
C1CC[C@]2([C@H]3CC4=C([C@]2(C1)CCN3CC5CCC5)C=C(C=C4)O)O

Synonyms

  • Butorfanol
  • (-)-butorphanol
  • levo-BC-2627
  • Butorphanolum
  • (-)-17-(Cyclobutylmethyl)morphinan-3,14-diol
  • Morphinan-3,14-diol, 17-(cyclobutylmethyl)-
  • (-)-N-cyclobutylmethyl-3,14-dihydroxymorphinan
  • (1S,9R,10S)-17-(cyclobutylmethyl)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-triene-4,10-diol
  • butorfanolo
  • (1S,9R,10S)-17-(cyclobutylmethyl)-17-azatetracyclo(7.5.3.0^(1,10).0^(2,7))heptadeca-2(7),3,5-triene-4,10-diol
  • (1S,9R,10S)-17-(cyclobutylmethyl)-17-azatetracyclo(7.5.3.01,10.02,7)heptadeca-2(7),3,5-triene-4,10-diol
  • (1S,9R,10S)-17-(cyclobutylmethyl)-17-azatetracyclo[7.5.3.0^{1,10}.0^{2,7}]heptadeca-2(7),3,5-triene-4,10-diol
  • BC 2627
  • Butorphanol (free base)
  • l-BC 2627
  • DEA No. 9720
  • Butorphanol (USAN/INN)
  • N-cyclobutylmethyl-3,14-dihydroxymorphinan
  • L-N-Cyclobutylmethyl-3,14-dihydroxymorphinan
  • d-N-Cyclobutylmethyl-3,14-dihydroxymorphinan

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
327.47 g/molcalc.
Exact mass
327.2198 Dacalc.
LogP (octanol/water)
3.37calc.
Topological polar surface area
43.7 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
2calc.
Heavy atoms
24calc.
Rings
5calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.71calc.
Formal charge
0calc.
Stereocentres
3calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)CC1C3CCCCC23CCN1CC1CCC1

c1ccc2c(c1)CC1C3CCCCC23CCN1CC1CCC1

5 rings, 22 atoms.

15 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H317May cause an allergic skin reaction.
  • H332Harmful if inhaled.
  • H334May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Precautionary statements (20)
  • P233Keep container tightly closed.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P317Get medical help.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P342 + P316If experiencing respiratory symptoms: Get emergency medical help immediately.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403Store in a well-ventilated place.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Butorphanol suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 15 suppliers
15 of 15 offers
  • Hikal Limited
    India, Navi Mumbai ManufacturerUnclaimed profile
    ButorphanolGrade, purity and minimum order on request
    Price on request
    View
  • Pro Test
    Poland, Warszawa ManufacturerUnclaimed profile
    ButorphanolGrade, purity and minimum order on request
    Price on request
    View
  • AHH Chemical co.,ltd
    China, ChangzhouUnclaimed profile
    ButorphanolGrade, purity and minimum order on request
    Price on request
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  • BenchChem
    United States, AustinUnclaimed profile
    ButorphanolGrade, purity and minimum order on request
    Price on request
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  • Clinivex
    Canada, ScarboroughUnclaimed profile
    ButorphanolGrade, purity and minimum order on request
    Price on request
    View
  • CymitQuimica
    Spain, BarcelonaUnclaimed profile
    ButorphanolGrade, purity and minimum order on request
    Price on request
    View
  • Debye Scientific Co., Ltd.
    Hong Kong, Hong KongUnclaimed profile
    ButorphanolGrade, purity and minimum order on request
    Price on request
    View
  • DempoChem
    Netherlands, RotterdamUnclaimed profile
    ButorphanolGrade, purity and minimum order on request
    Price on request
    View
  • EvitaChem
    China, BeijingUnclaimed profile
    ButorphanolGrade, purity and minimum order on request
    Price on request
    View
  • InvivoChem LLC
    China, GuangZhouUnclaimed profile
    ButorphanolGrade, purity and minimum order on request
    Price on request
    View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

15 suppliers in 9 countries

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Butorphanol price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Pharmacological actions

  • Analgesics, Opioid
  • Antitussive Agents
  • Narcotic Antagonists
  • Narcotics

Roles

  • agonist
  • analgesic
  • antitussive
  • kappa-opioid agent
  • kappa-opioid receptor agonist
  • mu-opioid agent
  • mu-opioid receptor agonist
  • neurotransmitter agent
  • opioid agent
  • opioid analgesic
  • opioid receptor agonist
  • pharmaceutical

Pharmacology

Butorphanol is an Opioid Agonist/Antagonist. The mechanism of action of butorphanol is as a Competitive Opioid Antagonist and Partial Opioid Agonist.

Regulatory status

Inventories, regulations and trade controls that list this substance

Controls

  • US DEA controlled substance or listed chemical

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Butorphanol is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Butorphanol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Butorphanol, based on the data on this page

What is Butorphanol?

Butorphanol is levorphanol in which a hydrogen at position 14 of the morphinan skeleton is substituted by hydroxy and one of the hydrogens of the N-methyl group is substituted by cyclopropyl.

What is the CAS number of Butorphanol?

The CAS registry number of Butorphanol is 42408-82-2. Other or deprecated CAS numbers: 58115-67-6.

What is the molecular formula and weight of Butorphanol?

The molecular formula of Butorphanol is C21H29NO2 and its molar mass is 327.47 g/mol.

What is Butorphanol used for?

Use classes: Pharmaceuticals.

Is Butorphanol hazardous?

Butorphanol carries the GHS signal word "Danger". Main hazards: harmful if swallowed, may cause an allergic skin reaction, harmful if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Butorphanol?

Butorphanol is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Butorphanol?

CompoundList lists 15 suppliers of Butorphanol in China, United States, Germany, Canada and 5 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Butorphanol in India?

1 supplier in India list Butorphanol on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Butorphanol?

Suppliers quote Butorphanol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Butorphanol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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