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Alkaloids

(+)-Catharanthine

Also known as Catharanthine, (+)-3,4-Didehydrocoronaridine, methyl (1R,15R,18R)-17-ethyl-3,13-diazapentacyclo[13.3.1.02,10.04,9.013,18]nonadeca-2(10),4,6,8,16-pentaene-1-carboxylate

CAS 2468-21-5Formula C21H24N2O2Molar mass 336.44 g/molEC 219-586-6
GHS signal word: Warning. Pictograms: Harmful or irritant 11 suppliers listed
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(+)-Catharanthine chemical structure, C21H24N2O2, CAS 2468-21-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
2468-21-5
Formula
C21H24N2O2
Molar mass
336.44 g/mol
EC number
219-586-6
HS code
293979
Category
Alkaloids

What is (+)-Catharanthine?

Plain description, key identifiers and synonyms

Catharanthine is an organic heteropentacyclic compound and monoterpenoid indole alkaloid produced by the medicinal plant Catharanthus roseus via strictosidine. It is a methyl ester, a bridged compound, an organic heteropentacyclic compound, an alkaloid ester, a tertiary amino compound and a monoterpenoid indole alkaloid. It is a conjugate base of a catharanthine(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
methyl (1R,15R,18R)-17-ethyl-3,13-diazapentacyclo[13.3.1.02,10.04,9.013,18]nonadeca-2(10),4,6,8,16-pentaene-1-carboxylate
CAS number
2468-21-5 CAS number cross-checked
EC number
219-586-6
Molecular formula
C21H24N2O2
UNII
WT0YJV846J
MDL number
MFCD01753356
InChIKey
CMKFQVZJOWHHDV-NQZBTDCJSA-N
InChI
InChI=1S/C21H24N2O2/c1-3-14-10-13-11-21(20(24)25-2)18-16(8-9-23(12-13)19(14)21)15-6-4-5-7-17(15)22-18/h4-7,10,13,19,22H,3,8-9,11-12H2,1-2H3/t13-,19+,21-/m0/s1
Canonical SMILES
CCC1=CC2CN3CCc4c([nH]c5ccccc45)C(C(=O)OC)(C2)C13
Isomeric SMILES
CCC1=C[C@H]2C[C@]3([C@@H]1N(C2)CCC4=C3NC5=CC=CC=C45)C(=O)OC

Synonyms

  • Catharanthine
  • (+)-3,4-Didehydrocoronaridine
  • methyl (1R,15R,18R)-17-ethyl-3,13-diazapentacyclo[13.3.1.02,10.04,9.013,18]nonadeca-2(10),4,6,8,16-pentaene-1-carboxylate
  • methyl (1R,15R,18R)-17-ethyl-3,13-diazapentacyclo(13.3.1.02,10.04,9.013,18)nonadeca-2(10),4,6,8,16-pentaene-1-carboxylate
  • Catharanthine Base
  • Ibogamine-18-carboxylic acid, 3,4-didehydro-, methyl ester, (2alpha,5beta,6alpha,18beta)-
  • Catharanthine, (+)-
  • (6R,6aR,9R,11R)-Methyl 7-ethyl-6,6a,9,10,12,13-hexahydro-5H-6,9-methanopyrido[1',2':1,2]azepino[4,5-b]indole-6-carboxylate
  • Catharanthine (free base)
  • Catharanthine, >=95% (HPLC)
  • Methyl (2alpha,5beta,6alpha)-3,4-didehydroibogamine-18beta-carboxylate
  • Methyl (2-alpha,5-beta,6-alpha,18-beta)-3,4-didehydroibogamine-18-carboxylate
  • Methyl (2?,5?,6?)-3,4-didehydroibogamine-18?-carboxylate
  • Methyl (6R)-2alpha,5beta,18beta-3,4-didehydroibogamine-18-carboxylate
  • Ibogamine-18-carboxylic acid, 3,4-didehydro-, methyl ester, (2|A,5|A,6|A,18|A)-
  • (6R,6aR,9R,11R)-Methyl7-ethyl-6,6a,9,10,12,13-hexahydro-5H-6,9-methanopyrido[1',2':1,2]azepino[4,5-b]indole-6-carboxylate
  • Ibogamine-18-carboxylic acid, 3,4-didehydro-, methyl ester, (2-alpha,5-beta,6-alpha,18-beta)-
  • Ibogamine-18-carboxylic acid, 3,4-didehydro-, methyl ester,(2alpha,5beta,6alpha,18.beta.)-
  • methyl (1R,15R,18R)-17-ethyl-3,13-diazapentacyclo[13.3.1.0^{2,10}.0^{4,9}.0^{13,18}]nonadeca-2(10),4(9),5,7,16-pentaene-1-carboxylate

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
336.44 g/molcalc.
Exact mass
336.1838 Dacalc.
LogP (octanol/water)
3.18calc.
Topological polar surface area
45.33 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
2calc.
Heavy atoms
25calc.
Rings
6calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.48calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1=CC2C3CC1CN2CCc1c3[nH]c2ccccc12

C1=CC2C3CC1CN2CCc1c3[nH]c2ccccc12

6 rings, 19 atoms.

10 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

(+)-Catharanthine suppliers

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All 11 suppliers
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Where suppliers are based

11 suppliers in 4 countries

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(+)-Catharanthine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Applications are not documented for this substance yet. Suppliers often describe uses on their product pages, linked in the suppliers list above.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code (+)-Catharanthine is traded under.

HS 2939.79Indicative HS code

Alkaloids of vegetal origin, other than cocaine, ecgonine, salts, esters and other derivatives, not elsewhere…

World exports in 2024
$701M
+18.9% vs 2023, imports $830M
2019 to 2024
Top exporters
  1. Switzerland * partner reported25.3%
  2. Germany21.4%
  3. India * partner reported14.9%
Top importers
  1. United States20.9%
  2. Germany14.7%
  3. Italy14.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for (+)-Catharanthine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about (+)-Catharanthine, based on the data on this page

What is (+)-Catharanthine?

Catharanthine is an organic heteropentacyclic compound and monoterpenoid indole alkaloid produced by the medicinal plant Catharanthus roseus via strictosidine.

What is the CAS number of (+)-Catharanthine?

The CAS registry number of (+)-Catharanthine is 2468-21-5.

What is the molecular formula and weight of (+)-Catharanthine?

The molecular formula of (+)-Catharanthine is C21H24N2O2 and its molar mass is 336.44 g/mol.

Is (+)-Catharanthine hazardous?

(+)-Catharanthine carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of (+)-Catharanthine?

(+)-Catharanthine is usually classified under HS code 293979 (Alkaloids, natural or reproduced by synthesis, and their salts, ethers, esters and other…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy (+)-Catharanthine?

CompoundList lists 11 suppliers of (+)-Catharanthine in China, United States, Czech Republic and United Kingdom. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of (+)-Catharanthine?

Suppliers quote (+)-Catharanthine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle (+)-Catharanthine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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