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Alkaloids

Cepharanthine

Also known as (+)-Cepharanthine, 6',12'-Dimethoxy-2,2'-dimethyl-6,7-(methylenebis(oxy))oxyacanthan, Cepharanthin

CAS 481-49-2Formula C37H38N2O6Molar mass 606.72 g/molEC 683-114-9
GHS signal word: Warning. Pictograms: Harmful or irritant 21 suppliers listed
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Cepharanthine chemical structure, C37H38N2O6, CAS 481-49-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
481-49-2
Formula
C37H38N2O6
Molar mass
606.72 g/mol
EC number
683-114-9
HS code
293979
Category
Alkaloids

What is Cepharanthine?

Plain description, key identifiers and synonyms

Cepharanthine is a bisbenzylisoquinoline alkaloid from tubers of Stephania, stimulates recovery of immunologic function in lymphatic system after administration of antineoplastic agents or x-irradiation. It is a bisbenzylisoquinoline alkaloid and a member of isoquinolines.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(14S,27R)-22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.216,19.13,10.121,25.04,8.031,35.014,39]nonatriaconta-1(33),3(39),4(8),9,16(38),17,19(37),21,23,25(36),31,34-dodecaene
CAS number
481-49-2 CAS number cross-checked
EC number
683-114-9
Molecular formula
C37H38N2O6
UNII
7592YJ0J6T
MDL number
MFCD00210482
InChIKey
YVPXVXANRNDGTA-WDYNHAJCSA-N
InChI
InChI=1S/C37H38N2O6/c1-38-13-11-24-18-31(41-4)33-20-27(24)28(38)16-23-7-10-30(40-3)32(17-23)44-26-8-5-22(6-9-26)15-29-35-25(12-14-39(29)2)19-34-36(37(35)45-33)43-21-42-34/h5-10,17-20,28-29H,11-16,21H2,1-4H3/t28-,29+/m1/s1
Canonical SMILES
COc1ccc2cc1Oc1ccc(cc1)CC1c3c(cc4c(c3Oc3cc5c(cc3OC)CCN(C)C5C2)OCO4)CCN1C
Isomeric SMILES
CN1CCC2=CC3=C(C4=C2[C@@H]1CC5=CC=C(C=C5)OC6=C(C=CC(=C6)C[C@@H]7C8=CC(=C(C=C8CCN7C)OC)O4)OC)OCO3

Synonyms

  • (+)-Cepharanthine
  • 6',12'-Dimethoxy-2,2'-dimethyl-6,7-(methylenebis(oxy))oxyacanthan
  • Cepharanthin
  • O-Methylcepharanoline
  • Cepharantin
  • Ex Cepharantha tuber
  • 4,37-dodecaene
  • Cepharanthine (JAN)
  • Oxyacanthan, 6',12'-dimethoxy-2,2'-dimethyl-6,7-(methylenebis(oxy))-
  • ecaene (non-preferred name)
  • Cepharanthine, 95%
  • Cepharanthine (Standard)
  • 4-27-00-09061 (Beilstein Handbook Reference)
  • Cepharanthine, >=95% (HPLC)
  • Cepharanthine, >=98% (HPLC)
  • Sdccgmls-0066893.p001

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
606.72 g/molcalc.
Exact mass
606.273 Dacalc.
LogP (octanol/water)
6.87calc.
Topological polar surface area
61.86 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
2calc.
Heavy atoms
45calc.
Rings
9calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.35calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1cc2cc(c1)Oc1ccc(cc1)CC1NCCc3cc4c(c(c31)Oc1ccc3c(c1)C(C2)NCC3)OCO4

c1cc2cc(c1)Oc1ccc(cc1)CC1NCCc3cc4c(c(c31)Oc1ccc3c(c1)C(C2)NCC3)OCO4

9 rings, 39 atoms.

11 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Cepharanthine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 21 suppliers
21 of 21 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

21 suppliers in 4 countries

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Cepharanthine price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Anti-Inflammatory Agents, Non-Steroidal
  • Antineoplastic Agents, Phytogenic
  • Radiation-Protective Agents

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Cepharanthine is traded under.

HS 2939.79Indicative HS code

Alkaloids of vegetal origin, other than cocaine, ecgonine, salts, esters and other derivatives, not elsewhere…

World exports in 2024
$701M
+18.9% vs 2023, imports $830M
2019 to 2024
Top exporters
  1. Switzerland * partner reported25.3%
  2. Germany21.4%
  3. India * partner reported14.9%
Top importers
  1. United States20.9%
  2. Germany14.7%
  3. Italy14.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Cepharanthine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Cepharanthine, based on the data on this page

What is Cepharanthine?

Cepharanthine is a bisbenzylisoquinoline alkaloid from tubers of Stephania, stimulates recovery of immunologic function in lymphatic system after administration of antineoplastic agents or x-irradiation. It is a bisbenzylisoquinoline alkaloid and a member of isoquinolines.

What is the CAS number of Cepharanthine?

The CAS registry number of Cepharanthine is 481-49-2.

What is the molecular formula and weight of Cepharanthine?

The molecular formula of Cepharanthine is C37H38N2O6 and its molar mass is 606.72 g/mol.

What is Cepharanthine used for?

Known uses and roles of Cepharanthine include anti-inflammatory agents, non-steroidal, antineoplastic agents, phytogenic and radiation-protective agents.

Is Cepharanthine hazardous?

Cepharanthine carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Cepharanthine?

Cepharanthine is usually classified under HS code 293979 (Alkaloids, natural or reproduced by synthesis, and their salts, ethers, esters and other…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Cepharanthine?

CompoundList lists 21 suppliers of Cepharanthine in China, United States, Hong Kong and Germany. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Cepharanthine?

Suppliers quote Cepharanthine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Cepharanthine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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