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Antibiotics and anti-infectives

Cephradine

Also known as Cefradine, Cephradin, Anspor

CAS 38821-53-3Formula C16H19N3O4SMolar mass 349.41 g/molEC 254-137-8
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 74 suppliers listed
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Cephradine chemical structure, C16H19N3O4S, CAS 38821-53-3
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
White, crystalline powder, polymorphic
Flash point
No Data
Solubility
SPARINGLY SOL IN WATER, VERY SLIGHTLY SOL ALC, PRACTICALLY INSOL IN CHLOROFORM & ETHER
HS code
294190
Category
Antibiotics and anti-infectives
Illustrative photo, off-white crystalline powder with an amber glass bottle on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Cephradine?

Plain description, key identifiers and synonyms

Cephradine is a first-generation cephalosporin antibiotic with a methyl substituent at position 3, and a (2R)-2-amino-2-cyclohexa-1,4-dien-1-ylacetamido substituent at position 7, of the cephem skeleton. It has a role as an antibacterial drug. It is a cephalosporin and a beta-lactam antibiotic allergen.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(6R,7R)-7-[[(2R)-2-amino-2-cyclohexa-1,4-dien-1-ylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS number
38821-53-3 CAS number cross-checked
EC number
254-137-8
Molecular formula
C16H19N3O4S
UNII
9YA6SX5S4D
MDL number
MFCD00865048
InChIKey
RDLPVSKMFDYCOR-UEKVPHQBSA-N
InChI
InChI=1S/C16H19N3O4S/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9/h2-3,6,10-11,15H,4-5,7,17H2,1H3,(H,18,20)(H,22,23)/t10-,11-,15-/m1/s1
Canonical SMILES
CC1=C(C(=O)O)N2C(=O)C(NC(=O)C(N)C3=CCC=CC3)C2SC1
Isomeric SMILES
CC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)[C@@H](C3=CCC=CC3)N)SC1)C(=O)O

Synonyms

  • Cefradine
  • Cephradin
  • Anspor
  • Sefril
  • Velosef
  • Cefradina
  • Eskacef
  • Cefradinum
  • SQ 11436
  • Cephradine anhydrous
  • (6R,7R)-7-((R)-2-Amino-2-(1,4-cyclohexadien-1-yl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid
  • 7-(D-2-Amino-2-(1,4-cyclohexadienyl)acetamide)desacetoxycephalosporanicacid
  • (6R,7R)-7-[[(2R)-2-amino-2-cyclohexa-1,4-dien-1-ylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • Cephradine hydrate
  • Cefradine hydrate
  • SK&F D-39304
  • (6R,7R)-7-[(2R)-2-amino-2-(cyclohexa-1,4-dien-1-yl)acetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • 7-(D-2-Amino-2-(1,4-cyclohexadien-1-yl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)-oct-2-ene-2-caboxylic acid
  • SK&F-D-39304
  • (6R,7R)-7-{[(2R)-2-amino-2-cyclohexa-1,4-dien-1-ylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((amino-1,4-cyclohexadien-1-ylacetyl)amino)-3-methyl-8-oxo-, (6R-(6alpha,7beta(R*)))-
  • (6R,7R)-7-(((2R)-2-Amino-2-cyclohexa-1,4-dien-1-ylacetyl)amino)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid
  • Ecosporina
  • (6R,7R)-7-((2R)-2-amino-2-(cyclohexa-1,4-dien-1-yl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid
  • Dihydrate, Cephradine
Show all 34 synonyms
  • 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(2-amino-2-(1,4-cyclohexadien-1-yl)acetamido)-3-methyl-8-oxo-, hydrate, D-
  • Velosef'125
  • Velosef'250
  • Velosef'500
  • Non-Stoichiometric Hydrate Cephradine
  • Cephradine, Non Stoichiometric Hydrate
  • Cefradin
  • (6R,7R)-7-((R)-2-Amino-2-(cyclohexa-1,4-dien-1-yl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • Megacef

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White, crystalline powder, polymorphicexp.
Flash point
No Dataexp.
Solubility
SPARINGLY SOL IN WATER, VERY SLIGHTLY SOL ALC, PRACTICALLY INSOL IN CHLOROFORM & ETHERexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
349.41 g/molcalc.
Exact mass
349.1096 Dacalc.
LogP (octanol/water)
0.35calc.
Topological polar surface area
112.7 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
4calc.
Heavy atoms
24calc.
Rings
3calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.44calc.
Formal charge
0calc.
Stereocentres
3calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(CC1=CCC=CC1)NC1C(=O)N2C=CCSC12

O=C(CC1=CCC=CC1)NC1C(=O)N2C=CCSC12

3 rings, 19 atoms.

10 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H315Causes skin irritation.
  • H317May cause an allergic skin reaction.
  • H319Causes serious eye irritation.
  • H334May cause allergy or asthma symptoms or breathing difficulties if inhaled.
  • H335May cause respiratory irritation.
Precautionary statements (23)
  • P233Keep container tightly closed.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P342 + P316If experiencing respiratory symptoms: Get emergency medical help immediately.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403Store in a well-ventilated place.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Cephradine suppliers

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All 74 suppliers
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Where suppliers are based

74 suppliers in 14 countries

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Cephradine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Anti-Bacterial Agents

Roles

  • antibacterial agent
  • antibacterial drug
  • antiinfective agent
  • antimicrobial agent
  • antimicrobial drug
  • pharmaceutical

Pharmacology

Cephradine anhydrous is a Cephalosporin Antibacterial.

How it is made

After suitably protecting amino group, d-2-phenyl-glycine is converted to benzoate ester which is then condensed with 7-aminodesacetoxycephalosporanic acid with aid of triethylamine. Cleavage of amino-protecting group with acid yields cephradine.

A semisynthetic cephalosporin.

D-alpha-phenylglycine + 7-amino-3-desacetoxycephalosporanic acid (Birch reduction/Dane salt formation/amide formation/hydrolysis)

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Cephradine is traded under.

HS 2941.90Indicative HS code

Antibiotics, other

World exports in 2024
$6.39B
+2.3% vs 2023, imports $6.97B
2019 to 2024
Top exporters
  1. China39.7%
  2. United States11.3%
  3. Switzerland * partner reported10.9%
Top importers
  1. Italy15.0%
  2. India * partner reported12.0%
  3. China8.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Cephradine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Cephradine, based on the data on this page

What is Cephradine?

Cephradine is a first-generation cephalosporin antibiotic with a methyl substituent at position 3, and a (2R)-2-amino-2-cyclohexa-1,4-dien-1-ylacetamido substituent at position 7, of the cephem skeleton. It has a role as an antibacterial drug. It is a cephalosporin and a beta-lactam antibiotic allergen.

What is the CAS number of Cephradine?

The CAS registry number of Cephradine is 38821-53-3.

What is the molecular formula and weight of Cephradine?

The molecular formula of Cephradine is C16H19N3O4S and its molar mass is 349.41 g/mol.

What is Cephradine used for?

Known uses and roles of Cephradine include antibacterials and antibiotics in pharmaceuticals, antibacterial agent, antibacterial drug, antiinfective agent, antimicrobial agent and 3 more.

Is Cephradine hazardous?

Cephradine carries the GHS signal word "Danger". Main hazards: causes skin irritation, may cause an allergic skin reaction, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Cephradine?

Cephradine is usually classified under HS code 294190 (Antibiotics, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Cephradine?

CompoundList lists 74 suppliers of Cephradine in China, Bangladesh, United States, Pakistan and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Cephradine in India?

5 suppliers in India list Cephradine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Cephradine?

Suppliers quote Cephradine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Cephradine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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