Chloroform
Also known as Trichloromethane, Trichlormethan, Trichloroform
Key facts
What buyers check first
- Appearance
- Highly refractive, nonflammable, heavy, very volatile liquid
- Melting point
- -63.5 °C
- Boiling point
- 61.1 °C
- Density
- 1.4788 g/cm³ at 25 °C
- Flash point
- None
- HS code
- 290313
- Category
- Refrigerants and blowing agents
- UN number
- UN 1888
What is Chloroform?
Plain description, key identifiers and synonyms
Chloroform is a one-carbon compound that is methane in which three of the hydrogens are replaced by chlorines. It has a role as a central nervous system drug, an inhalation anaesthetic, a non-polar solvent, a carcinogenic agent and a refrigerant. It is a member of chloromethanes and a one-carbon compound.
Identifiers
Registry numbers, names and line notations, tap to copy
- IUPAC name
- chloroform
- CAS number
- 67-66-3 CAS number cross-checked
- EC number
- 200-663-8
- Molecular formula
- CHCl3
- UNII
- 7V31YC746X
- MDL number
- MFCD00000826
- INCI name
- CHLOROFORM
- InChIKey
- HEDRZPFGACZZDS-UHFFFAOYSA-N
- InChI
- InChI=1S/CHCl3/c2-1(3)4/h1H
- SMILES (canonical and isomeric)
- C(Cl)(Cl)Cl
Synonyms
- Trichloromethane
- Trichlormethan
- Trichloroform
- Formyl trichloride
- Methane, trichloro-
- Methenyl trichloride
- Methyl trichloride
- Methane trichloride
- Chloroforme
- CHCl3
- R 20 (Refrigerant)
- Triclorometano
- Cloroformio
- Trichloormethaan
- Freon 20
- 1,1,1-Trichloromethane
- Methenyl chloride
- RCRA waste number U044
- Chloroformum
- Chloroform bp
- Hcc 20
- Methylidyne trichloride
- Refrigerant R20
- trichloro-methane
- Chloroform, acs
Show all 31 synonymsShow fewer synonyms
- CHLOROFORMWith Amylene
- CHLOROFORMWith Ethanol
- chloroform CHCl3
- Chloroform (Stabilized with ~1% Ethanol)
- Chloroform, analytical standard
- Chloroform (Anhydrous) Contains Amylenes as stabilizer
Physical and chemical properties
Measured values and descriptors computed from the structure
Physical and chemical properties
Measured values, check the supplier specification for your grade
| Appearance | Highly refractive, nonflammable, heavy, very volatile liquidexp.Measured value |
|---|---|
| Odour | Pleasant, etheric, nonirritatingexp.Measured value |
| Taste | Sweet tasteexp.Measured value |
| Melting point | -63.5 °Cexp.Measured value |
| Boiling point | 61.1 °Cexp.Measured value |
| Density | 1.4788 g/cm³ at 25 °Cexp.Measured value |
| Flash point | Noneexp.Measured value |
| Autoignition temperature | Not flammableexp.Measured value |
| Solubility | In water, 7.95 × 10⁺³ mg/L at 25 °Cexp.Measured value |
| Vapour pressure | VP: 100 mm Hg at 10.4 °Cexp.Measured value |
Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.
Computed descriptors
Calculated from the structure, useful for screening and formulation
| Molecular weight | 119.38 g/molcalc.Computed value |
|---|---|
| Exact mass | 117.9144 Dacalc.Computed value |
| LogP (octanol/water) | 1.99calc.Computed value |
| Topological polar surface area | 0 Ųcalc.Computed value |
| Hydrogen bond donors | 0calc.Computed value |
| Hydrogen bond acceptors | 0calc.Computed value |
| Rotatable bonds | 0calc.Computed value |
| Heavy atoms | 4calc.Computed value |
| Rings | 0calc.Computed value |
| Aromatic rings | 0calc.Computed value |
| Fraction sp3 carbons | 1calc.Computed value |
| Formal charge | 0calc.Computed value |
| Stereocentres | 0calc.Computed value |
| Lipinski rule of five | Passes (0 violations)calc.Computed value |
Calculated for screening. Confirm critical figures with the supplier.
Safety and hazards
GHS classification summary, not a safety data sheet
Hazard statements
- H302Harmful if swallowed.
- H315Causes skin irritation.
- H319Causes serious eye irritation.
- H331Toxic if inhaled.
- H351Suspected of causing cancer.
- H361dSuspected of damaging the unborn child.
- H372Causes damage to organs through prolonged or repeated exposure.
Precautionary statements (23)
- P203Obtain, read and follow all safety instructions before use.
- P260Do not breathe dust, fume, gas, mist, vapours or spray.
- P261Avoid breathing dust, fume, gas, mist, vapours or spray.
- P264Wash skin thoroughly after handling.
- P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
- P270Do not eat, drink or smoke when using this product.
- P271Use only outdoors or in a well-ventilated area.
- P280Wear protective gloves, protective clothing, eye protection and face protection.
- P301 + P317If swallowed: Get medical help.
- P302 + P352If on skin: Wash with plenty of water.
- P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
- P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P316Get emergency medical help immediately.
- P318If exposed or concerned, get medical advice.
- P319Get medical help if you feel unwell.
- P321Specific treatment (see supplemental first aid instructions on the label).
- P330Rinse mouth.
- P332 + P317If skin irritation occurs: Get medical help.
- P337 + P317If eye irritation persists: Get medical help.
- P362 + P364Take off contaminated clothing. And wash it before reuse.
- P403 + P233Store in a well-ventilated place. Keep container tightly closed.
- P405Store locked up.
- P501Dispose of contents and container in accordance with local regulations.
- UN number
- UN 1888
- Transport hazard class
- 6.1
- Packing group
- III
GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.
Full safety data and first aidChloroform suppliers
Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings
- India, Vadodara ManufacturerUnclaimed profileChloroformGrade, purity and minimum order on requestPrice on request
- India, ChennaiUnclaimed profileChloroformGrade, purity and minimum order on requestPrice on request
- India, MumbaiUnclaimed profileChloroformGrade, purity and minimum order on requestPrice on request
- India, Ahmedabad ManufacturerUnclaimed profileChloroformGrade, purity and minimum order on requestPrice on request
- Germany, HamburgUnclaimed profileChloroformGrade, purity and minimum order on requestPrice on request
- Italy, MilanoUnclaimed profileChloroformGrade, purity and minimum order on requestPrice on request
- France, CourbevoieUnclaimed profileChloroformGrade, purity and minimum order on requestPrice on request
- Thailand, Bang KhaeUnclaimed profileChloroformGrade, purity and minimum order on requestPrice on request
- India, Panchkula ManufacturerUnclaimed profileChloroformGrade, purity and minimum order on requestPrice on request
- JapanUnclaimed profileChloroformGrade, purity and minimum order on requestPrice on request
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Where suppliers are based
280 suppliers in 34 countries
- India96
- United States44
- China40
- United Kingdom10
- Germany8
- Japan8
- and 28 more countries
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Chloroform price
Indicative price range per kg from live supplier offers
Suppliers quote this chemical on request. Send one free request and compare quotes side by side.
Uses and applications
What the substance is used for, by industry and function
Chloroform is now used primarily in the manufacture of HCFC-22, monochlorodifluoromethane, a refrigerant and as a raw material for polytetrafluoroethylene plastics.
In the manufacture of fluorocarbon-22. As a solvent for fats, oils, rubber, alkaloids, waxes, gutta-percha, resins, as cleansing agent, in fire extinguishers to lower the freezing temp of carbon tetrachloride, in the rubber industry.
Chloroform is still used to a limited extent as an extractant for pharmaceutical products. Due to its toxicological properties, its use as an inhalatory anaesthetic is no longer significant. Small amounts are employed in the synthesis of orthoformic esters.
The vast majority of the chloroform produced in the United States is used to make HCFC-22. The rest is produced for export and for miscellaneous uses.
Industrial uses: Laboratory chemicals, Intermediate, Solvent.
Use classes: Volatile organic compounds.
Industries and functions
Cosmetic ingredient, INCI name CHLOROFORM(solvent)
Pharmacological actions
- Solvents
Roles
- aetiopathogenetic role
- anaesthetic
- carcinogenic agent
- central nervous system drug
- general anaesthetic
- inhalation anaesthetic
- non-polar solvent
- pharmaceutical
- refrigerant
- solvent
Functional uses
- Processing aids not otherwise specified
- Solvent
Cosmetic functions
- Solvent
Pharmacology
Chloroform is a colorless, volatile, liquid derivative of methane with an ether-like odor. Formerly used as an inhaled anesthetic during surgery, the primary use of chloroform today is in industry, where it is used as a solvent and in the production of the refrigerant freon. Acute chloroform toxicity results in impaired liver function, cardiac arrhythmia, nausea and central nervous system dysfunction. As a byproduct of water chlorination, chloroform may be present in small amounts in chlorinated water. (NCI04)
How it is made
From the addition of sulfuric acid to acetone and bleaching powder: 2CH3COCH3 + 6CaOCl2.H2O (yields) 2CHCl3 + (CH3COO)2Ca + 2Ca(OH)2 + 3CaCl2 + 6H2O. May also be prepared by carefully controlled chlorination of methane...
Prepared exclusively and on a massive scale by the chlorination of methane and/or monochloromethane.
(1) Reaction of chlorinated lime with acetone, acetaldehyde, or ethanol, (2) by-product from the chlorination of methane.
Regulatory status
Inventories, regulations and trade controls that list this substance
Europe
- EU harmonised classification (CLP Annex VI)Index no: 602-006-00-4
Health and food
- EU cosmetic ingredient inventory
- EU Cosmetics Regulation Annex II, prohibited in cosmeticsName: Chloroform, Ref no: 366, Annex ref: II/366
- Active ingredient in FDA approved drug labels
United States
- TSCA inventory (USA)Status: Active in US commerce
HS code and trade data
Customs classification and reported world trade statistics
Global trade
World import and export statistics for the HS code Chloroform is traded under.
Chloroform (trichloromethane)
- Germany34.8%
- France * partner reported20.9%
- United States16.4%
- Netherlands17.6%
- Japan17.6%
- United States12.7%
* Partner reported figures, a lower bound.
The HS code shown for Chloroform is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.
Related chemicals
Parent and salt forms, stereoisomers, similar structures and isomers
Salt and hydrate forms
Records that share this compound as their parent
Stereoisomers and isotopic forms
Same connectivity, different stereochemistry or isotopes (same InChIKey skeleton)
Frequently asked questions
Quick answers about Chloroform, based on the data on this page
What is Chloroform?
What is the CAS number of Chloroform?
What is the molecular formula and weight of Chloroform?
What is Chloroform used for?
Is Chloroform hazardous?
What is the HS code of Chloroform?
Where can I buy Chloroform?
Where can I buy Chloroform in India?
What is the price of Chloroform?
Guides for buyers
Practical guides that help when you source, ship or handle Chloroform
- Guide, Trade and logisticsShipping dangerous goods: UN numbers, classes and packing groupsHow the UN dangerous goods system works for chemicals, from the nine classes and UN numbers to packing groups, UN packaging marks, labels, documents and segregation.Read
- Guide, SafetyHow to read a safety data sheet in 10 minutesA section by section method to pull the essentials out of any 16 section SDS: identity, hazards, composition, storage, PPE, properties, transport and emergency measures.Read
- Guide, SafetyGHS pictograms, signal words and hazard statements explainedA practical guide to the nine GHS pictograms, the signal words Danger and Warning, H and P statements, and how to read a chemical label in seconds.Read
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