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Cardiovascular and metabolic drugs

Ciglitazone

Also known as Ciglitizone, Ciglitazona, Ciglitazonum

CAS 74772-77-3Formula C18H23NO3SMolar mass 333.45 g/molEC 692-459-4
GHS signal word: Warning. Pictograms: Serious health hazard 30 suppliers listed
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Ciglitazone chemical structure, C18H23NO3S, CAS 74772-77-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
74772-77-3
Formula
C18H23NO3S
Molar mass
333.45 g/mol
EC number
692-459-4
HS code
293410
Category
Cardiovascular and metabolic drugs

What is Ciglitazone?

Plain description, key identifiers and synonyms

Ciglitazone is an aromatic ether that consists of 1,3-thiazolidine-2,4-dione with position 5 substituted by a 4-[(1-methylcyclohexyl)methoxy]benzyl group. A selective PPARgamma agonist. It has a role as an antineoplastic agent and an insulin-sensitizing drug. It is an aromatic ether and a thiazolidinone.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
5-[[4-[(1-methylcyclohexyl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
CAS number
74772-77-3 CAS number cross-checked
EC number
692-459-4
Molecular formula
C18H23NO3S
UNII
U8QXS1WU8G
MDL number
MFCD00865499
InChIKey
YZFWTZACSRHJQD-UHFFFAOYSA-N
InChI
InChI=1S/C18H23NO3S/c1-18(9-3-2-4-10-18)12-22-14-7-5-13(6-8-14)11-15-16(20)19-17(21)23-15/h5-8,15H,2-4,9-12H2,1H3,(H,19,20,21)
SMILES (canonical and isomeric)
CC1(CCCCC1)COC2=CC=C(C=C2)CC3C(=O)NC(=O)S3

Synonyms

  • Ciglitizone
  • Ciglitazona
  • Ciglitazonum
  • 5-[[4-[(1-methylcyclohexyl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
  • 5-{4-[(1-methylcyclohexyl)methoxy]benzyl}-1,3-thiazolidine-2,4-dione
  • 5-({4-[(1-methylcyclohexyl)methoxy]phenyl}methyl)-1,3-thiazolidine-2,4-dione
  • 5-(4-((1-methylcyclohexyl)methoxy)benzyl)-1,3-thiazolidine-2,4-dione
  • 5-((4-((1-methylcyclohexyl)methoxy)phenyl)methyl)-1,3-thiazolidine-2,4-dione
  • 5-(4-(1-methylcyclohexylmethoxy)benzyl)thiazolidine-2,4-dione
  • ADD 3878
  • 5-(4-((1-methylcyclohexyl)methoxy)benzyl)thiazolidine-2,4-dione
  • 5-[[4-[(1-Methylcyclohexyl)methoxy]phenyl]methyl]-2,4-thiazolidinedione
  • (+-)-5-(p-((1-Methylcyclohexyl)methoxy)benzyl)-2,4-thiazolidinedione
  • (+/-)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione
  • Ciglitazone (USAN/INN)
  • Ciglitizone, >=98% (HPLC)
  • Bio1_000144
  • Bio1_000633
  • Bio1_001122
  • Bio2_000295
  • Bio2_000775
  • 2,4-Thiazolidinedione, 5-[[4-[(1-methylcyclohexyl)methoxy]phenyl]methyl]-
  • 2,4-Thiazolidinedione, 5-((4-((1-methylcyclohexyl)methoxy)phenyl)methyl)-, (+-)-
  • 5-[4-(1-methylcyclohexylmethyloxy)benzyl]thiazolidine-2,4-dione
  • (+/-)-5-[4-(1-Methylcyclohexylmethoxy)-benzyl]thiazolidine-2,4-dione
Show all 29 synonyms
  • 5-[[4-[(1-Methylcyclohexyl)methoxy] phenyl]methyl]-2,4-thiazolidinedione
  • 5-[[4-[(1-methylcyclohexyl)methoxy]phenyl]methyl]thiazolidine-2,4-dione
  • (+/-)-5-(P-((1-methylcyclohexyl)methoxy)benzyl)-2,4-thiazolidinedione
  • 2,4-Thiazolidinedione, 5-((4-((1-methylcyclohexyl)methoxy)phenyl)methyl)-, (+/-)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
333.45 g/molcalc.
Exact mass
333.1399 Dacalc.
LogP (octanol/water)
3.93calc.
Topological polar surface area
55.4 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
5calc.
Heavy atoms
23calc.
Rings
3calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.56calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1NC(=O)C(Cc2ccc(OCC3CCCCC3)cc2)S1

O=C1NC(=O)C(Cc2ccc(OCC3CCCCC3)cc2)S1

3 rings, 22 atoms.

3 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H361Suspected of damaging fertility or the unborn child.
Precautionary statements (5)
  • P203Obtain, read and follow all safety instructions before use.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Ciglitazone suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 30 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

30 suppliers in 5 countries

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Ciglitazone price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Pharmacological actions

  • Hypoglycemic Agents

Roles

  • PPAR modulator
  • agonist
  • antineoplastic agent
  • hypoglycemic agent
  • insulin-sensitizing drug
  • pharmaceutical

Pharmacology

Ciglitazone is an agent belonging to the glitazone (thiazolidinedione) class of antidiabetic agents with antihyperglycemic activity. Ciglitazone also exerts anti-inflammatory activity through the modulation of nuclear factor-kappaB-mediated pathways. In addition, this agent inhibits angiogenesis by reducing vascular endothelial growth factor (VEGF) production and inhibits growth of melanoma cells by inhibiting the expression of (C-X-C motif) ligand 1 (CXCL1). This agent is the prototypical compound for the thiazolidinedione class, and has never been marketed.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Ciglitazone is traded under.

HS 2934.10Indicative HS code

Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the…

World exports in 2024
$3.88B
−16.1% vs 2023, imports $3.12B
2019 to 2024
Top exporters
  1. Switzerland * partner reported36.4%
  2. Ireland28.8%
  3. China10.0%
Top importers
  1. Canada33.4%
  2. United States14.4%
  3. Ireland13.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Ciglitazone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Ciglitazone, based on the data on this page

What is Ciglitazone?

Ciglitazone is an aromatic ether that consists of 1,3-thiazolidine-2,4-dione with position 5 substituted by a 4-[(1-methylcyclohexyl)methoxy]benzyl group. A selective PPARgamma agonist. It has a role as an antineoplastic agent and an insulin-sensitizing drug. It is an aromatic ether and a thiazolidinone.

What is the CAS number of Ciglitazone?

The CAS registry number of Ciglitazone is 74772-77-3.

What is the molecular formula and weight of Ciglitazone?

The molecular formula of Ciglitazone is C18H23NO3S and its molar mass is 333.45 g/mol.

What is Ciglitazone used for?

Known uses and roles of Ciglitazone include antidiabetics in pharmaceuticals, ppar modulator, agonist, antineoplastic agent, hypoglycemic agent and 3 more.

Is Ciglitazone hazardous?

Ciglitazone carries the GHS signal word "Warning". Main hazards: suspected of damaging fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Ciglitazone?

Ciglitazone is usually classified under HS code 293410 (Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Ciglitazone?

CompoundList lists 30 suppliers of Ciglitazone in United States, China, United Kingdom, Australia and 1 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Ciglitazone?

Suppliers quote Ciglitazone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Ciglitazone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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