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Respiratory, allergy and digestive drugs

Cisapride

Also known as Cisaprida, Cisapridum, Enteropride

CAS 81098-60-4Formula C23H29ClFN3O4Molar mass 465.95 g/molEC 279-689-7
GHS signal word: Danger. Pictograms: Corrosive 43 suppliers listed Drug substance
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Cisapride chemical structure, C23H29ClFN3O4, CAS 81098-60-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
81098-60-4
Formula
C23H29ClFN3O4
Appearance
White to slightly biege powder
Solubility
Practically insoluble in water.
HS code
293339
Category
Respiratory, allergy and digestive drugs
Illustrative photo, fine white powder in a white HDPE jar on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Cisapride?

Plain description, key identifiers and synonyms

Cisapride is the amide resulting from formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with cis-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-amine. It has been used (as its monohydrate or as its tartrate) for the treatment of gastro-oesophageal reflux disease and for non-ulcer dyspepsia, but its propensity to cause cardiac arrhythmias resulted in its complete withdrawal from many countries, including the U.K., and restrictions on its use elsewhere. It has a role as a serotonergic agonist, an anti-ulcer drug and a gastrointestinal drug. It is a member of benzamides, a member of piperidines, an aromatic ether, an organofluorine compound, a substituted aniline and a member of monochlorobenzenes.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-amino-5-chloro-N-[(3S,4R)-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl]-2-methoxybenzamide
CAS number
81098-60-4 CAS number cross-checkedOther or deprecated CAS: 260779-88-2, 86718-70-9
EC numbers
279-689-7, 623-862-5
Molecular formula
C23H29ClFN3O4
UNII
UVL329170W
InChIKey
DCSUBABJRXZOMT-IRLDBZIGSA-N
InChI
InChI=1S/C23H29ClFN3O4/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29)/t20-,22+/m1/s1
Canonical SMILES
COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC
Isomeric SMILES
CO[C@H]1CN(CC[C@H]1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F

Synonyms

  • Cisaprida
  • Cisapridum
  • Enteropride
  • Kinestase
  • Pridesia
  • Prepulsid
  • 4-amino-5-chloro-N-[(3S,4R)-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl]-2-methoxybenzamide
  • cis-4-Amino-5-chloro-N-(1-(3-(p-fluorophenoxy)propyl)-3-methoxy-4-piperidyl)-o-anisamide
  • Benzamide, 4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-3-methoxy-4-piperidinyl)-2-methoxy-, cis-
  • 4-amino-5-chloro-N-((3S,4R)-1-(3-(4-fluorophenoxy)propyl)-3-methoxypiperidin-4-yl)-2-methoxybenzamide
  • Prepulsid quicklet
  • cis-4-amino-5-chloro-N-(1-(3-(p-fluorophenoxy)propyl)-3-methoxy-4-piperidinyl)-o-anisamide
  • cis-4-amino-5-chloro-N-{1-[3-(p-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl}-o-anisamide
  • Propulsid Quicksolv
  • 4-Amino-5-chloro-N-(1-(3-(4-fluoro-phenoxy)-propyl)-3-methoxy-piperidin-4-yl)-2-methoxy-benzamide
  • 4-Amino-5-chloro-N-{(3S,4R)-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl}-2-methoxybenzamide
  • 4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl]-3-methoxy-piperidin-4-yl}-2-methoxy-benzamide
  • cis-4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-3-methoxy-4-piperidinyl)-2-methoxybenzamide
  • cis-4-amino-5-chloro-N-{1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl}-2-methoxybenzamide
  • 4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-3-methoxypiperidin-4-yl)-2-methoxybenzamide
  • (+-)-Cisapride
  • Acenalin
  • Propulsin
  • Risamol
  • C23H29ClFN3O4
Show all 38 synonyms
  • Acpulsif
  • Alipride
  • Cipride
  • Cisapron
  • Cisawal
  • Colinorm
  • Kaudalit
  • Rapulid
  • Syspride
  • Unipride
  • Vomiprid
  • Vomipride
  • Dispep

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White to slightly biege powderexp.
Odour
Odorlessexp.
Solubility
Practically insoluble in water.exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
465.95 g/molcalc.
Exact mass
465.1831 Dacalc.
LogP (octanol/water)
3.36calc.
Topological polar surface area
86.05 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
9calc.
Heavy atoms
32calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.44calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(NC1CCN(CCCOc2ccccc2)CC1)c1ccccc1

O=C(NC1CCN(CCCOc2ccccc2)CC1)c1ccccc1

3 rings, 25 atoms.

18 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS05: Corrosive
Corrosive

Hazard statements

  • H318Causes serious eye damage.
Precautionary statements (4)
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P317Get medical help.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Cisapride suppliers

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All 43 suppliers
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Where suppliers are based

43 suppliers in 14 countries

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Cisapride price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Pharmacological actions

  • Anti-Ulcer Agents
  • Gastrointestinal Agents
  • Serotonin Receptor Agonists

Roles

  • anti-ulcer drug
  • gastrointestinal drug
  • neurotransmitter agent
  • pharmaceutical
  • serotonergic agonist
  • serotonergic drug

Pharmacology

Cisapride is a substituted piperidinyl benzamide prokinetic agent. Cisapride facilitates release of acetylcholine from the myenteric plexus, resulting in increased gastrointestinal motility. In addition, cisapride has been found to act as a serotonin agonist, stimulating type 4 receptors, and a serotonin 5-HT3 receptor antagonist. (NCI)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Cisapride is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Cisapride is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Cisapride, based on the data on this page

What is Cisapride?

Cisapride is the amide resulting from formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with cis-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-amine.

What is the CAS number of Cisapride?

The CAS registry number of Cisapride is 81098-60-4. Other or deprecated CAS numbers: 260779-88-2, 86718-70-9.

What is the molecular formula and weight of Cisapride?

The molecular formula of Cisapride is C23H29ClFN3O4 and its molar mass is 465.95 g/mol.

What is Cisapride used for?

Known uses and roles of Cisapride include cns agents in pharmaceuticals, anti-ulcer drug, gastrointestinal drug, neurotransmitter agent, pharmaceutical and 5 more.

Is Cisapride hazardous?

Cisapride carries the GHS signal word "Danger". Main hazards: causes serious eye damage. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Cisapride?

Cisapride is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Cisapride?

CompoundList lists 43 suppliers of Cisapride in China, United States, Spain, United Kingdom and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Cisapride in India?

1 supplier in India list Cisapride on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Cisapride?

Suppliers quote Cisapride on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Cisapride

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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