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Skin conditioning agents and actives

Creatine

Also known as Creatin, N-amidinosarcosine, Kreatin

CAS 57-00-1Formula C4H9N3O2Molar mass 131.14 g/molEC 200-306-6
GHS signal word: Warning. Pictograms: Harmful or irritant 120 suppliers listed
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Creatine chemical structure, C4H9N3O2, CAS 57-00-1
2D chemical structure

Key facts

What buyers check first

All properties
Physical form
Solid
Melting point
303 °C
Density
1.33 at 25 °C
Solubility
Slightly soluble in water, insoluble in ether
HS code
292529
Category
Skin conditioning agents and actives
Illustrative photo, closed white HDPE bottles and amber jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Creatine?

Plain description, key identifiers and synonyms

Creatine is a glycine derivative having methyl and amidino groups attached to the nitrogen. It has a role as a geroprotector, a nutraceutical, a neuroprotective agent, a mouse metabolite and a human metabolite. It is a glycine derivative and a member of guanidines. It is a conjugate acid of a creatinate. It is a tautomer of a creatine zwitterion.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-[carbamimidoyl(methyl)amino]acetic acid
CAS number
57-00-1 CAS number cross-checkedOther or deprecated CAS: 1093737-19-9, 6020-87-7
EC number
200-306-6
Molecular formula
C4H9N3O2
UNII
MU72812GK0
MDL number
MFCD00004282
INCI name
CREATINE
InChIKey
CVSVTCORWBXHQV-UHFFFAOYSA-N
InChI
InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9)
SMILES (canonical and isomeric)
CN(CC(=O)O)C(=N)N

Synonyms

  • Creatin
  • N-amidinosarcosine
  • Kreatin
  • Krebiozon
  • methylglycocyamine
  • N-methyl-N-guanylglycine
  • Glycine, N-(aminoiminomethyl)-N-methyl-
  • Pyrolysate
  • (alpha-Methylguanido)acetic acid
  • N-carbamimidoyl-N-methylglycine
  • Cosmocair C 100
  • Kreatinum
  • Neotine
  • 2-(1-methylcarbamimidamido)acetic acid
  • N-(aminoiminomethyl)-N-methylglycine
  • alpha-Methylguanidino acetic acid
  • 2-[carbamimidoyl(methyl)amino]acetic acid
  • (N-methylcarbamimidamido)acetic acid
  • ((amino(imino)methyl)(methyl)amino)acetic acid
  • N-[(E)-Amino(imino)methyl]-N-methylglycine
  • 2-(carbamimidoyl(methyl)amino)acetic acid
  • [[Amino(imino)methyl](methyl)amino]acetic acid
  • N-((E)-Amino(imino)methyl)-N-methylglycine
  • 2-(1-Methylguanidino)acetic acid
  • Creatine, hydrate
Show all 37 synonyms
  • Creatine, anhydrous
  • Methylguanidoacetic acid
  • Creatine anhydrous
  • N-Methyl-N-amidinoglycine
  • 2-(N-methylcarbamimidamido)acetic acid
  • N-Guanyl-N-methylglycine
  • N-(Aminoiminomethyl)-N-methyl-glycine
  • 2-(amidinomethylamino)acetic acid
  • Creatine (8CI)
  • ((amino(imino)methyl)(methyl)amino)acetate
  • [[Amino(imino)methyl](methyl)amino]acetate
  • Kre-Alkalyn

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Physical form
Solidexp.
Melting point
303 °Cexp.
Density
1.33 at 25 °Cexp.
Solubility
Slightly soluble in water, insoluble in etherexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
131.14 g/molcalc.
Exact mass
131.0695 Dacalc.
LogP (octanol/water)
-1.1calc.
Topological polar surface area
90.41 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
2calc.
Heavy atoms
9calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.5calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Creatine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 120 suppliers
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Where suppliers are based

120 suppliers in 22 countries

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Creatine price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Used in diagnosis of myocardial disfunction, dietary supplement for exercise performance.

Cosmetic ingredient, INCI name CREATINE(skin conditioning)

Roles

  • animal metabolite
  • anti-inflammatory agent
  • antidepressant
  • antidyskinesia agent
  • antineoplastic agent
  • antiparkinson drug
  • antipsychotic agent
  • central nervous system depressant
  • central nervous system drug
  • eukaryotic metabolite
  • geroprotector
  • human metabolite
  • immunomodulator
  • immunosuppressive agent
  • mammalian metabolite
  • metabolite
  • mouse metabolite
  • neuroprotective agent
  • nutraceutical
  • pharmaceutical
  • protective agent
  • psychotropic drug
  • tranquilizing drug

Functional uses

  • Softener and conditioner

Cosmetic functions

  • Skin conditioning

Pharmacology

Creatine is an endogenous amino acid derivative produced by vertebrate animals and occurring primarily in muscle cells. Creatine is important for energy storage, it is phosphorylated to creatine phosphate, which serves as a phosphate donor in the conversion of ADP to ATP and supplies energy necessary for muscle contraction. Dietary supplementation with creatine may improve muscle wasting associated with cancer and other chronic diseases.

How it is made

Monosubstituted and N,N-disubstituted compounds, including guanidinocarboxylic acids (eg, creatine), are produced industrially by the reaction of cyanamide with the corresponding amines or aminocarboxylic acids.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Creatine is traded under.

HS 2925.29Indicative HS code

Imines and their derivatives, salts thereof, other

World exports in 2024
$1.8B
+12.4% vs 2023, imports $1.84B
2019 to 2024
Top exporters
  1. China35.9%
  2. France * partner reported15.5%
  3. Germany9.1%
Top importers
  1. United States13.3%
  2. China13.0%
  3. Brazil9.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Creatine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Creatine, based on the data on this page

What is Creatine?

Creatine is a glycine derivative having methyl and amidino groups attached to the nitrogen. It has a role as a geroprotector, a nutraceutical, a neuroprotective agent, a mouse metabolite and a human metabolite. It is a glycine derivative and a member of guanidines. It is a conjugate acid of a creatinate.

What is the CAS number of Creatine?

The CAS registry number of Creatine is 57-00-1. Other or deprecated CAS numbers: 1093737-19-9, 6020-87-7.

What is the molecular formula and weight of Creatine?

The molecular formula of Creatine is C4H9N3O2 and its molar mass is 131.14 g/mol.

What is Creatine used for?

Used in diagnosis of myocardial disfunction, dietary supplement for exercise performance.

Is Creatine hazardous?

Creatine carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Creatine?

Creatine is usually classified under HS code 292529 (Imines and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Creatine?

CompoundList lists 120 suppliers of Creatine in China, United States, Germany, United Kingdom and 18 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Creatine in India?

1 supplier in India list Creatine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Creatine?

Suppliers quote Creatine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Creatine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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