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Amino acids and derivatives

D-Proline

Also known as (2R)-pyrrolidine-2-carboxylic acid, (R)-pyrrolidine-2-carboxylic acid, D-(+)-Proline

CAS 344-25-2Formula C5H9NO2Molar mass 115.13 g/molEC 206-452-7
GHS signal word: Warning. Pictograms: Harmful or irritant 30 suppliers listed
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D-Proline chemical structure, C5H9NO2, CAS 344-25-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
344-25-2
Formula
C5H9NO2
Molar mass
115.13 g/mol
EC number
206-452-7
HS code
293399
Category
Amino acids and derivatives

What is D-Proline?

Plain description, key identifiers and synonyms

D-proline is the D-enantiomer of proline. It has a role as a mouse metabolite. It is a D-alpha-amino acid and a proline. It is a conjugate base of a D-prolinium. It is a conjugate acid of a D-prolinate. It is an enantiomer of a L-proline. It is a tautomer of a D-proline zwitterion.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2R)-pyrrolidine-2-carboxylic acid
CAS number
344-25-2 CAS number cross-checkedOther or deprecated CAS: 1331908-17-8
EC number
206-452-7
Molecular formula
C5H9NO2
UNII
L01Q4LGZ5L
MDL number
MFCD00064317
InChIKey
ONIBWKKTOPOVIA-SCSAIBSYSA-N
InChI
InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
Canonical SMILES
O=C(O)C1CCCN1
Isomeric SMILES
C1C[C@@H](NC1)C(=O)O

Synonyms

  • (2R)-pyrrolidine-2-carboxylic acid
  • (R)-pyrrolidine-2-carboxylic acid
  • D-(+)-Proline
  • D-Prolin
  • (R)-Proline
  • (R)-2-Carboxypyrrolidine
  • Proline, d-
  • (+)-(R)-Proline
  • (2R)-pyrrolidin-1-ium-2-carboxylate
  • H-D-Pro-OH
  • R-Proline
  • D-Pro
  • H-Pros-OH
  • (D)-proline
  • Captopril Impurity 32
  • D-D-Pro-OH
  • R)-2-Carboxypyrrolidine
  • (2R)-pyrrolidine-2-carboxylate
  • d-2-pyrrolidinecarboxylic acid
  • H-DPro-OH
  • (R)-pyrrolidine-2-carboxylate
  • pyrrolidine-2-(R)-carboxylic acid
  • D-Proline, ReagentPlus(R), >=99%
  • D-Proline, Vetec(TM) reagent grade, 98%

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
115.13 g/molcalc.
Exact mass
115.0633 Dacalc.
LogP (octanol/water)
-0.18calc.
Topological polar surface area
49.33 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
1calc.
Heavy atoms
8calc.
Rings
1calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.8calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1CCNC1

C1CCNC1

1 ring, 5 atoms, the Pyrrolidine ring system.

22,348 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

D-Proline suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 30 suppliers
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Where suppliers are based

30 suppliers in 4 countries

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D-Proline price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Roles

  • animal metabolite
  • eukaryotic metabolite
  • mammalian metabolite
  • metabolite
  • mouse metabolite

Regulatory status

Inventories, regulations and trade controls that list this substance

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code D-Proline is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for D-Proline is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about D-Proline, based on the data on this page

What is D-Proline?

D-proline is the D-enantiomer of proline. It has a role as a mouse metabolite. It is a D-alpha-amino acid and a proline. It is a conjugate base of a D-prolinium. It is a conjugate acid of a D-prolinate. It is an enantiomer of a L-proline. It is a tautomer of a D-proline zwitterion.

What is the CAS number of D-Proline?

The CAS registry number of D-Proline is 344-25-2. Other or deprecated CAS numbers: 1331908-17-8.

What is the molecular formula and weight of D-Proline?

The molecular formula of D-Proline is C5H9NO2 and its molar mass is 115.13 g/mol.

What is D-Proline used for?

Known uses and roles of D-Proline include animal metabolite, eukaryotic metabolite, mammalian metabolite, metabolite and mouse metabolite.

Is D-Proline hazardous?

D-Proline carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of D-Proline?

D-Proline is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy D-Proline?

CompoundList lists 30 suppliers of D-Proline in China, United States, India and Canada. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy D-Proline in India?

2 suppliers in India list D-Proline on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of D-Proline?

Suppliers quote D-Proline on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle D-Proline

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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