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Peptides

Darinaparsin

Also known as clarinaparsin, DMAs(III)G, DMAs(III)SG

CAS 69819-86-9Formula C12H22AsN3O6SMolar mass 411.31 g/molEC 684-606-6
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Hazardous to the environment 2 suppliers listed
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Darinaparsin chemical structure, C12H22AsN3O6S, CAS 69819-86-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
69819-86-9
Formula
C12H22AsN3O6S
Molar mass
411.31 g/mol
EC number
684-606-6
HS code
293190
Category
Peptides

What is Darinaparsin?

Plain description, key identifiers and synonyms

(2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-3-(dimethylarsinothio)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid is a peptide.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-3-dimethylarsanylsulfanyl-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
CAS number
69819-86-9 CAS number cross-checked
EC number
684-606-6
Molecular formula
C12H22AsN3O6S
UNII
9XX54M675G
MDL number
MFCD17215931
InChIKey
JGDXFQORBMPJGR-YUMQZZPRSA-N
InChI
InChI=1S/C12H22AsN3O6S/c1-13(2)23-6-8(11(20)15-5-10(18)19)16-9(17)4-3-7(14)12(21)22/h7-8H,3-6,14H2,1-2H3,(H,15,20)(H,16,17)(H,18,19)(H,21,22)/t7-,8-/m0/s1
Canonical SMILES
C[As](C)SCC(NC(=O)CCC(N)C(=O)O)C(=O)NCC(=O)O
Isomeric SMILES
C[As](C)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N

Synonyms

  • clarinaparsin
  • DMAs(III)G
  • DMAs(III)SG
  • Darinaparsina
  • Darinaparsine
  • dimethylarsinous glutathione
  • S-dimethylarsino-glutathione
  • S-(dimethylarsino)glutathione
  • S-(dimethylarsino)-glutathione
  • darinaparsinum
  • Dmaiii(sg)
  • ZIO 101
  • Zinapar
  • (2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-3-dimethylarsanylsulfanyl-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
  • L-gamma-Glutamyl-S-(dimethylarsanyl)-L-cysteinylglycine
  • C12H22AsN3O6S
  • Darvias (TN)
  • SGLU1
  • S-dimethylarsinoglutathione
  • Darinaparsin (JAN/USAN)
  • S-Dimethylarsino Glutathione
  • (S)-2-amino-5-(((R)-1-((carboxymethyl)amino)-3-((dimethylarsino)thio)-1-oxopropan-2-yl)amino)-5-oxopentanoic acid
  • Glycine, L-|A-glutaMyl-S-(diMethylarsino)-L-cysteinyl-
  • Glycine, L-gamma-glutamyl-S-(dimethylarsino)-L-cysteinyl
  • l-gamma-glutamyl-S-(dimethylarsino)-l-cysteinyl-glycine
Show all 27 synonyms
  • Glycine, l-gamma-glutamyl-S-(dimethylarsino)-l-cysteinyl-
  • (2S)-2-amino-5-[[(1R)-2-(carboxymethylamino)-1-(dimethylarsanylsulfanylmethyl)-2-oxo-ethyl]amino]-5-oxo-pentanoic acid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
411.31 g/molcalc.
Exact mass
411.0445 Dacalc.
LogP (octanol/water)
-1.15calc.
Topological polar surface area
158.8 Ųcalc.
Hydrogen bond donors
5calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
11calc.
Heavy atoms
23calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.67calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H301Toxic if swallowed.
  • H331Toxic if inhaled.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (14)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P273Avoid release to the environment.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P316Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P391Collect spillage.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Darinaparsin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 2 suppliers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

2 suppliers in 2 countries

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Darinaparsin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Pharmacology

Darinaparsin is a small-molecule organic arsenical with potential antineoplastic activity. Although the exact mechanism of action is unclear, darinaparsin, a highly toxic metabolic intermediate of inorganic arsenicals (iAs) that occurs in vivo, appears to generate volatile cytotoxic arsenic compounds when glutathione (GSH) concentrations are low.

Read more

The arsenic compounds generated from darinaparsin disrupt mitochondrial bioenergetics, producing reactive oxygen species (ROS) and inducing ROS-mediated tumor cell apoptosis, in addition, this agent or its byproducts may initiate cell death by interrupting the G2/M phase of the cell cycle and may exhibit antiangiogenic effects. Compared to inorganic arsenic compounds such as arsenic trioxide (As2O3), darinaparsin appears to exhibit a wide therapeutic window.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Darinaparsin is traded under.

HS 2931.90Indicative HS code

Organo-inorganic compounds, other than tetramethyl lead, tetraethyl lead, tributyltin compounds…

World exports in 2024
$3.97B
+5.3% vs 2023, imports $3.93B
2019 to 2024
Top exporters
  1. China28.3%
  2. United States15.6%
  3. Germany15.1%
Top importers
  1. United States14.6%
  2. China13.0%
  3. South Korea8.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Darinaparsin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Darinaparsin, based on the data on this page

What is Darinaparsin?

(2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-3-(dimethylarsinothio)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid is a peptide.

Is Darinaparsin hazardous?

Darinaparsin carries the GHS signal word "Danger". Main hazards: toxic if swallowed, toxic if inhaled, very toxic to aquatic life. This summary is not an SDS, always read the supplier safety data sheet.

Guides for buyers

Practical guides that help when you source, ship or handle Darinaparsin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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