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Antibiotics and anti-infectives

(-)-Dehydrocostus lactone

Also known as Dehydrocostus lactone, Dehydrocostus lactone, (-)-, (3aS,6aR,9aR,9bS)-3,6,9-trimethylidene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-2-one

CAS 477-43-0Formula C15H18O2Molar mass 230.31 g/molEC 683-106-5
GHS signal word: Warning. Pictograms: Harmful or irritant 10 suppliers listed
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(-)-Dehydrocostus lactone chemical structure, C15H18O2, CAS 477-43-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
477-43-0
Formula
C15H18O2
Molar mass
230.31 g/mol
EC number
683-106-5
HS code
293220
Category
Antibiotics and anti-infectives

What is (-)-Dehydrocostus lactone?

Plain description, key identifiers and synonyms

Dehydrocostus lactone is an organic heterotricyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-bis(methylene)decahydoazulen-5-yl group and in which the hydroxy group and the carboxy group have undergone formal condensation to afford the corresponding gamma-lactone. It has a role as a metabolite, an antineoplastic agent, a trypanocidal drug, a cyclooxygenase 2 inhibitor, an antimycobacterial drug and an apoptosis inducer. It is an organic heterotricyclic compound, a guaiane sesquiterpenoid, a gamma-lactone and a sesquiterpene lactone.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(3aS,6aR,9aR,9bS)-3,6,9-trimethylidene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-2-one
CAS number
477-43-0 CAS number cross-checked
EC number
683-106-5
Molecular formula
C15H18O2
UNII
71TRF5K040
MDL number
MFCD00210277
InChIKey
NETSQGRTUNRXEO-XUXIUFHCSA-N
InChI
InChI=1S/C15H18O2/c1-8-4-7-12-10(3)15(16)17-14(12)13-9(2)5-6-11(8)13/h11-14H,1-7H2/t11-,12-,13-,14-/m0/s1
Canonical SMILES
C=C1C(=O)OC2C1CCC(=C)C1CCC(=C)C12
Isomeric SMILES
C=C1CC[C@@H]2[C@@H]([C@@H]3[C@H]1CCC3=C)OC(=O)C2=C

Synonyms

  • Dehydrocostus lactone
  • Dehydrocostus lactone, (-)-
  • (3aS,6aR,9aR,9bS)-3,6,9-trimethylidene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-2-one
  • (3aR,6aS,9aS,9bR)-3,6,9-tris(methylidene)octahydroazuleno[4,5-b]furan-2,8(3H,4H)-dione
  • Azuleno(4,5-b)furan-2(3H)-one, decahydro-3,6,9-tris(methylene)-, (3aS-(3aalpha,6aalpha,9aalpha,9bbeta))-
  • (3aR,6aS,9aS,9bR)-3,6,9-tris(methylidene)octahydroazuleno(4,5-b)furan-2,8(3H,4H)-dione
  • (3aS,6aR,9aR,9bS)-3,6,9-trimethylidene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno(4,5-b)furan-2-one
  • dehydrocostuslactone
  • Epiligulyl oxide
  • (-)-dehydrocostuslactone
  • (3aS,6aR,9aR,9bS)-3,6,9-trimethylenedecahydroazuleno[4,5-b]furan-2(3H)-one
  • (3aS,6aR,9aR,9bS)-decahydro-3,6,9-tris(methylene)azuleno[4,5-b]furan-2(3H)-one
  • (3aS,6aR,9aR,9bS)-3,6,9-Trimethylenedecahydroazuleno[4,5-b]furan-2(9bH)-one
  • (3aS,6aR,9aR,9bS)-3,6,9-trimethylene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-2-one
  • (3as,6ar,9ar,9bs)-3,6,9-trimethylidenedecahydroazuleno[4,5-b]furan-2(3h)-one
  • dihydrocostuslactone
  • (-)-Dehydrocostus lactone, Epiligulyl oxide
  • Dehydrocostus-Lactone
  • Costus lactone, dehydro-
  • Dehydrocostus Lactone (Standard)
  • Azuleno[4,5-b]furan-2(3H)-one,decahydro-3,6,9-tris(methylene)-
  • Dehydrocostus lactone, >=98% (HPLC)
  • Dehydrocostus lactone, analytical standard
  • 4(15),10(14),11(13)-guaiatrien-12,6-olide
  • (3aR,6aS,9aS,9bR)-3,6,9-tris(methylene)octahydroazuleno[4,5-b]furan-2,8(3H,4H)-dione
Show all 27 synonyms
  • Azuleno(4,5-b)furan-2(3H)-one, decahydro-3,6,9-tris(methylene)-, (3as,6ar,9ar,9bs)-
  • Guaia-4(15),10(14),11(13)-trien-12-oic acid, 6alpha-hydroxy-, gamma-lactone

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
230.31 g/molcalc.
Exact mass
230.1307 Dacalc.
LogP (octanol/water)
3.02calc.
Topological polar surface area
26.3 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
0calc.
Heavy atoms
17calc.
Rings
3calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.53calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C=C1C(=O)OC2C1CCC(=C)C1CCC(=C)C12

C=C1C(=O)OC2C1CCC(=C)C1CCC(=C)C12

3 rings, 17 atoms, the 3,6,9-Trimethylidene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno(4,5-b)furan-2-one ring system.

14 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H317May cause an allergic skin reaction.
Precautionary statements (8)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

(-)-Dehydrocostus lactone suppliers

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Where suppliers are based

10 suppliers in 2 countries

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(-)-Dehydrocostus lactone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antibacterial agent
  • antibacterial drug
  • antiinfective agent
  • antimicrobial agent
  • antimicrobial drug
  • antimycobacterial drug
  • antineoplastic agent
  • antiparasitic agent
  • antiprotozoal drug
  • apoptosis inducer
  • cyclooxygenase 2 inhibitor
  • enzyme inhibitor
  • metabolite
  • pharmaceutical
  • trypanocidal drug

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code (-)-Dehydrocostus lactone is traded under.

HS 2932.20Indicative HS code

Lactones

World exports in 2024
$1.97B
−4.7% vs 2023, imports $2.07B
2019 to 2024
Top exporters
  1. China56.3%
  2. India * partner reported7.4%
  3. Germany7.3%
Top importers
  1. United States14.2%
  2. India * partner reported13.5%
  3. Brazil8.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for (-)-Dehydrocostus lactone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about (-)-Dehydrocostus lactone, based on the data on this page

What is (-)-Dehydrocostus lactone?

Dehydrocostus lactone is an organic heterotricyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-bis(methylene)decahydoazulen-5-yl group and in which the hydroxy group and the carboxy group have undergone formal condensation to afford the cor…

What is the CAS number of (-)-Dehydrocostus lactone?

The CAS registry number of (-)-Dehydrocostus lactone is 477-43-0.

What is the molecular formula and weight of (-)-Dehydrocostus lactone?

The molecular formula of (-)-Dehydrocostus lactone is C15H18O2 and its molar mass is 230.31 g/mol.

What is (-)-Dehydrocostus lactone used for?

Known uses and roles of (-)-Dehydrocostus lactone include antibacterials and antibiotics in pharmaceuticals, antibacterial agent, antibacterial drug, antiinfective agent, antimicrobial agent and 11 more.

Is (-)-Dehydrocostus lactone hazardous?

(-)-Dehydrocostus lactone carries the GHS signal word "Warning". Main hazards: may cause an allergic skin reaction. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of (-)-Dehydrocostus lactone?

(-)-Dehydrocostus lactone is usually classified under HS code 293220 (Lactones). This is indicative, confirm it with your customs broker before shipping.

Where can I buy (-)-Dehydrocostus lactone?

CompoundList lists 10 suppliers of (-)-Dehydrocostus lactone in China and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of (-)-Dehydrocostus lactone?

Suppliers quote (-)-Dehydrocostus lactone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle (-)-Dehydrocostus lactone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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