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Synthetic aroma chemicals

Diethyl malonate

Also known as Diethyl propanedioate, Ethyl malonate, Malonic ester

CAS 105-53-3Formula C7H12O4Molar mass 160.17 g/molEC 203-305-9
GHS signal word: Warning. Pictograms: Harmful or irritant 94 suppliers listed
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Diethyl malonate chemical structure, C7H12O4, CAS 105-53-3
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless liquid
Melting point
-50 °C
Boiling point
200 °C
Density
1.0551 g/cm³ at 20 °C
Flash point
93 °C
HS code
291719
Category
Synthetic aroma chemicals
Illustrative photo, clear liquid in a volumetric flask on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Diethyl malonate?

Plain description, key identifiers and synonyms

Ethyl malonate is a dicarboxylic acid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
diethyl propanedioate
CAS number
105-53-3 CAS number cross-checkedOther or deprecated CAS: 2676-55-3
EC number
203-305-9
Molecular formula
C7H12O4
UNII
53A58PA183
MDL number
MFCD00009195
INCI name
DIETHYL MALONATE
InChIKey
IYXGSMUGOJNHAZ-UHFFFAOYSA-N
InChI
InChI=1S/C7H12O4/c1-3-10-6(8)5-7(9)11-4-2/h3-5H2,1-2H3
SMILES (canonical and isomeric)
CCOC(=O)CC(=O)OCC

Synonyms

  • Diethyl propanedioate
  • Ethyl malonate
  • Malonic ester
  • Propanedioic acid, diethyl ester
  • Carbethoxyacetic ester
  • Malonic acid, diethyl ester
  • Dicarbethoxymethane
  • 1,3-diethyl propanedioate
  • Ethyl propanedioate
  • Ethyl methanedicarboxylate
  • Methanedicarboxylic acid, diethyl ester
  • Propanedioic acid, 1,3-diethyl ester
  • diethylmalonate
  • Malonic acid diethyl ester
  • Ethyl malonate (VAN)
  • propanedioic acid diethyl ester
  • diethyl propane-1,3-dioate
  • Malonic acid diethyl
  • dietyl malonate
  • Propanedioic acid 1,3-diethyl ester
  • malonic acid-diethylester
  • CH2(COOEt)2
  • Diethyl propanedioate, 9CI
  • Diethyl malonate, >=98%, FG
  • Diethyl malonate, analytical standard
Show all 32 synonyms
  • Diethyl malonate, ReagentPlus(R), 99%
  • Diethyl malonate, purum, >=97.0% (GC)
  • Diethyl malonate, puriss., >=99.0% (GC)
  • Diethyl malonate Solution in Acetone, 100ug/mL
  • Diethyl malonate, Vetec(TM) reagent grade, 98%
  • Diethyl malonate Solution in Acetone, 1000ug/mL
  • Propanedioic acid,diethyl ester (malonic acid,diethyl ester)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless liquidexp.
Odour
Sweet ester odorexp.
Taste
Sweet and fruity taste with apple and pineapple nuancesexp.
Melting point
-50 °Cexp.
Boiling point
200 °Cexp.
Density
1.0551 g/cm³ at 20 °Cexp.
Flash point
93 °Cexp.
Autoignition temperature
435 °Cexp.
Solubility
In water, 20 g/L at 20 °Cexp.
Vapour pressure
0.19 mm Hg at 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
160.17 g/molcalc.
Exact mass
160.0736 Dacalc.
LogP (octanol/water)
0.5calc.
Topological polar surface area
52.6 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
4calc.
Heavy atoms
11calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.71calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
210NFPA 704 rating

Hazard statements

  • H319Causes serious eye irritation.
Precautionary statements (4)
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P337 + P317If eye irritation persists: Get medical help.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Diethyl malonate suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 94 suppliers
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Where suppliers are based

94 suppliers in 14 countries

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Diethyl malonate price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Dimethyl and diethyl malonates are widely used for the production of vitamins, pharmaceuticals, agrochemicals, fragrances, and dyes.

Manufacture of barbiturates.

Table: Reported uses (ppm): [Table#8510].

Diethyl malonate was used to investigate Knoevenagel condensation reactions in microreactor using zeolite catalysts obtained by grafting amino groups onto NaX and CsNaX zeolites. It may be used in the synthesis of diethyl benzylidenemalonate by base catalyzed Knoevenagel condensation with benzaldehyde. It may be used in the synthesis of a-aryl malonates.

Table: Concentration in final product (%) [Table#8511].

Industrial uses: Processing aids not otherwise specified, Chemical reaction regulator, Flavoring and nutrient, Intermediate, Fragrance.

Consumer uses: Chemical reaction regulator, Fragrance.

Cosmetic ingredient, INCI name DIETHYL MALONATE(perfuming)

Functional uses

  • Flavouring and nutrient
  • Fragrance

Cosmetic functions

  • Perfuming

How it is made

By passing hydrogen chloride into cyanoacetic acid dissolved in absolute alcohol with subsequent distillation.

Carbon Monoxide Process. According to this process, dimethyl, diethyl, and diisopropyl malonates are produced by a dicobalt octacarbonyl-catalyzed reaction of chloroacetates (methyl, ethyl, or isopropyl) with carbon monoxide in the presence of the appropriate alcohol. In the case of diethyl malonate the reaction is conducted at around 100 °C and 18 bar at pH 5.7. Ethyl acetate is formed as a major byproduct. After completion of the reaction, sodium chloride and catalyst are separated.

Read more

The alcohol and the low-boiling components are distilled off and the nonconverted chloroacetate recovered by distillation. The crude ethyl malonate obtained is purified by redistillation.

Reacting chloroacetic acid to cyanoacetic acid using sodium cyanide and subsequent saponification, malonic acid if finally esterified by azeotropic distillation with ethanol in benzene.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Diethyl malonate is traded under.

HS 2917.19Indicative HS code

Acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and…

World exports in 2024
$718M
+8.1% vs 2023, imports $915M
2019 to 2024
Top exporters
  1. China46.6%
  2. United States13.7%
  3. Germany10.1%
Top importers
  1. United States16.2%
  2. Denmark11.8%
  3. Germany10.0%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Diethyl malonate is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Diethyl malonate, based on the data on this page

What is Diethyl malonate?

Ethyl malonate is a dicarboxylic acid.

What is the CAS number of Diethyl malonate?

The CAS registry number of Diethyl malonate is 105-53-3. Other or deprecated CAS numbers: 2676-55-3.

What is the molecular formula and weight of Diethyl malonate?

The molecular formula of Diethyl malonate is C7H12O4 and its molar mass is 160.17 g/mol.

What is Diethyl malonate used for?

Dimethyl and diethyl malonates are widely used for the production of vitamins, pharmaceuticals, agrochemicals, fragrances, and dyes. Manufacture of barbiturates. Table: Reported uses (ppm): [Table#8510].

Is Diethyl malonate hazardous?

Diethyl malonate carries the GHS signal word "Warning". Main hazards: causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Diethyl malonate?

Diethyl malonate is usually classified under HS code 291719 (Acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Diethyl malonate?

CompoundList lists 94 suppliers of Diethyl malonate in China, India, United States, Germany and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Diethyl malonate in India?

27 suppliers in India list Diethyl malonate on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Diethyl malonate?

Suppliers quote Diethyl malonate on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Diethyl malonate

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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