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Steroids and sterols

Diosgenin

Also known as Nitogenin, (3beta,25R)-spirost-5-en-3-ol, (25R)-spirost-5-en-3beta-diol

CAS 512-04-9Formula C27H42O3Molar mass 414.63 g/molEC 208-134-3
GHS signal word: Warning. Pictograms: Harmful or irritant 73 suppliers listed
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Diosgenin chemical structure, C27H42O3, CAS 512-04-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
512-04-9
Formula
C27H42O3
Molar mass
414.63 g/mol
EC number
208-134-3
HS code
293299
Category
Steroids and sterols

What is Diosgenin?

Plain description, key identifiers and synonyms

Diosgenin is a sapogenin that is spirostan which is substituted by a hydroxy group at the 3beta position, contains a double bond at the 5-6 position, and has R- configuration at position 25. A natural product found in Dioscorea (wild yam) species, it is used as the starting point for the commercial synthesis of a number of steroids, including cortisone, pregnenolone and progesterone. It has a role as an antiviral agent, a metabolite, an antineoplastic agent and an apoptosis inducer. It is a sapogenin, a 3beta-sterol, a hexacyclic triterpenoid and a spiroketal. It derives from a hydride of a spirostan.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R,16S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-ol
CAS number
512-04-9 CAS number cross-checked
EC number
208-134-3
Molecular formula
C27H42O3
UNII
K49P2K8WLX
MDL number
MFCD00016887
INCI name
DIOSGENIN
InChIKey
WQLVFSAGQJTQCK-VKROHFNGSA-N
InChI
InChI=1S/C27H42O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h5,16-17,19-24,28H,6-15H2,1-4H3/t16-,17+,19+,20-,21+,22+,23+,24+,25+,26+,27-/m1/s1
Canonical SMILES
CC1CCC2(OC1)OC1CC3C4CC=C5CC(O)CCC5(C)C4CCC3(C)C1C2C
Isomeric SMILES
C[C@@H]1CC[C@@]2([C@H]([C@H]3[C@@H](O2)C[C@@H]4[C@@]3(CC[C@H]5[C@H]4CC=C6[C@@]5(CC[C@@H](C6)O)C)C)C)OC1

Synonyms

  • Nitogenin
  • (3beta,25R)-spirost-5-en-3-ol
  • (25R)-spirost-5-en-3beta-diol
  • Spirost-5-en-3-ol, (3beta,25R)-
  • (1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R,16S)-5',7,9,13-tetramethylspiro(5-oxapentacyclo(10.8.0.02,9.04,8.013,18)icos-18-ene-6,2'-oxane)-16-ol
  • (1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R,16S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-ol
  • Diosgenine
  • Disogenin
  • (25R)-Spirost-5-en-3beta-ol
  • (20R,25R)-Spirost-5-en-3beta-ol
  • (25R)-14beta,17beta-spirost-5-en-3beta-ol
  • SP 37
  • Spirost-5-en-3beta-ol, (25R)-
  • Spirost-5-en-3-ol, (3b,25R)-
  • nitrogen in
  • Diosgenin CRS
  • 22alpha-Spirost-5-en-3beta-ol
  • YUV
  • Diosgenin (Standard)
  • Diosgenin, >=93%
  • 3A-Hydroxy-5-spirostene
  • 3?-Hydroxy-5-spirostene
  • 5-19-03-00030 (Beilstein Handbook Reference)
  • (25R)-5-Spirosten-3b-ol
  • (25R)-5-Spirosten-3A-ol
Show all 33 synonyms
  • (3|_,25R)-spirost-5-en-3-ol
  • (3|A,25R)-Spirost-5-en-3-ol
  • Spirost-5-en-3-beta-ol, (25R)-
  • Spirost-5-en-3-ol, (3-beta,25R)-
  • doi:10.14272/WQLVFSAGQJTQCK-VKROHFNGSA-N.1
  • Diosgenin (constituent of fenugreek seed)
  • Diosgenin, European Pharmacopoeia (EP) Reference Standard
  • (25R)-5-Spirosten-3(1/4)?-ol, 3(1/4)?-Hydroxy-5-spirostene

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
414.63 g/molcalc.
Exact mass
414.3134 Dacalc.
LogP (octanol/water)
5.71calc.
Topological polar surface area
38.69 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
0calc.
Heavy atoms
30calc.
Rings
6calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.93calc.
Formal charge
0calc.
Stereocentres
11calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1=C2CCCCC2C2CCC3C4CC5(CCCCO5)OC4CC3C2C1

C1=C2CCCCC2C2CCC3C4CC5(CCCCO5)OC4CC3C2C1

6 rings, 25 atoms.

35 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
  • H413May cause long lasting harmful effects to aquatic life.
Precautionary statements (17)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Diosgenin suppliers

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Where suppliers are based

73 suppliers in 13 countries

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Diosgenin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name DIOSGENIN(skin conditioning)

Roles

  • antimicrobial agent
  • antineoplastic agent
  • antiviral agent
  • apoptosis inducer
  • metabolite
  • pharmaceutical

Functional uses

  • Softener and conditioner

Cosmetic functions

  • Skin conditioning

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Diosgenin is traded under.

HS 2932.99Indicative HS code

Heterocyclic compounds with oxygen hetero-atom(s) only, other

World exports in 2024
$3.81B
+10.3% vs 2023, imports $7.05B
2019 to 2024
Top exporters
  1. China28.9%
  2. Switzerland * partner reported12.7%
  3. Germany7.8%
Top importers
  1. United States49.7%
  2. China11.9%
  3. India * partner reported3.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Diosgenin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Diosgenin, based on the data on this page

What is Diosgenin?

Diosgenin is a sapogenin that is spirostan which is substituted by a hydroxy group at the 3beta position, contains a double bond at the 5-6 position, and has R- configuration at position 25.

What is the CAS number of Diosgenin?

The CAS registry number of Diosgenin is 512-04-9.

What is the molecular formula and weight of Diosgenin?

The molecular formula of Diosgenin is C27H42O3 and its molar mass is 414.63 g/mol.

What is Diosgenin used for?

Known uses and roles of Diosgenin include skin conditioning agents in cosmetics and personal care, antimicrobial agent, antineoplastic agent, antiviral agent, apoptosis inducer and 4 more.

Is Diosgenin hazardous?

Diosgenin carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Diosgenin?

Diosgenin is usually classified under HS code 293299 (Heterocyclic compounds with oxygen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Diosgenin?

CompoundList lists 73 suppliers of Diosgenin in China, United States, United Kingdom, India and 9 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Diosgenin in India?

3 suppliers in India list Diosgenin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Diosgenin?

Suppliers quote Diosgenin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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