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Cardiovascular and metabolic drugs

Dofetilide

Also known as Tikosyn, Dofetilida, Dofetilidum

CAS 115256-11-6Formula C19H27N3O5S2Molar mass 441.58 g/molEC 638-817-5
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard, Hazardous to the environment 107 suppliers listed Drug substance
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Dofetilide chemical structure, C19H27N3O5S2, CAS 115256-11-6
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
White to off-white powder
Melting point
147 to 149
Solubility
Very slightly soluble in water
HS code
293590
Category
Cardiovascular and metabolic drugs
Illustrative photo, fine white powder in an amber glass reagent bottle on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Dofetilide?

Plain description, key identifiers and synonyms

Dofetilide is a tertiary amino compound that is N-ethyl-N-methylethanamine substituted by a 4-[(methylsulfonyl)amino]phenoxy and a 4-[(methylsulfonyl)amino]phenyl group at the terminal carbon atoms respectively. It is used as an anti-arrhythmia drug. It has a role as an anti-arrhythmia drug and a potassium channel blocker. It is a sulfonamide, an aromatic ether and a tertiary amino compound.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-[4-[2-[2-[4-(methanesulfonamido)phenoxy]ethyl-methylamino]ethyl]phenyl]methanesulfonamide
CAS number
115256-11-6 CAS number cross-checked
EC number
638-817-5
Molecular formula
C19H27N3O5S2
UNII
R4Z9X1N2ND
MDL number
MFCD00869707
InChIKey
IXTMWRCNAAVVAI-UHFFFAOYSA-N
InChI
InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3
SMILES (canonical and isomeric)
CN(CCC1=CC=C(C=C1)NS(=O)(=O)C)CCOC2=CC=C(C=C2)NS(=O)(=O)C

Synonyms

  • Tikosyn
  • Dofetilida
  • Dofetilidum
  • UK-68,798
  • beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide
  • Methanesulfonamide, N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-
  • N-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]methanesulfonamide
  • Methanesulfonamide, N-(4-(2-(methyl(2-(4-((methylsulfonyl)amino)phenoxy)ethyl)amino)ethyl)phenyl)-
  • 1-Mspmpe
  • N-[4-(2-{[2-(4-methanesulfonamidophenoxy)ethyl](methyl)amino}ethyl)phenyl]methanesulfonamide
  • N-(4-{2-[methyl(2-{4-[(methylsulfonyl)amino]phenoxy}ethyl)amino]ethyl}phenyl)methanesulfonamide
  • N-(4-(2-(2-(4-methanesulfonamidophenyl)ethyl-methylamino)ethoxy)phenyl)methanesulfonamide
  • N-[4-[2-[2-(4-methanesulfonamidophenyl)ethyl-methylamino]ethoxy]phenyl]methanesulfonamide
  • Dofetilide 0.5mg
  • N-(4-(2-((2-(4-methanesulfonamidophenoxy)ethyl)(methyl)amino)ethyl)phenyl)methanesulfonamide
  • N-(4-(2-(methyl(2-(4-((methylsulfonyl)amino)phenoxy)ethyl)amino)ethyl)phenyl)methanesulfonamide
  • Dofetilde
  • 1-(4-methanesulfonamidophenoxy)-2-(N-(4-methanesulfonamidophenethyl)-N-methylamine)ethane
  • Dofetilide 0.25mg
  • Dofetilide 0.125mg
  • N-(4-(2-(methyl(2-(4-(methylsulfonamido)phenoxy)ethyl)amino)ethyl)phenyl)methanesulfonamide
  • UK 68798
  • N-[4-[2-[2-[4-(methanesulfonamido)phenoxy]ethyl-methylamino]ethyl]phenyl]methanesulfonamide
  • 1-(4-Methanesulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino]ethane
  • Dofetilide (>90%)
Show all 33 synonyms
  • N-[4-(2-{[2-(4-methanesulfonamidophenyl)ethyl](methyl)amino}ethoxy)phenyl]methanesulfonamide
  • N-[4-(2-{2-[4-(methanesulphonamido)phenoxyl]-N-methylethylamino}ethyl)phenyl]-methanesulphonamide
  • Xelide
  • Tikosyn (TN)
  • UK 68,798
  • N-[4-[2-[Methyl[2-[4-(methylsulfonamido)phenoxy]ethyl]amino]ethyl]phenyl]methanesulfonamide
  • Dofetilide (Standard)
  • Dofetilide (Tikosyn)?

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White to off-white powderexp.
Melting point
147 to 149exp.
Solubility
Very slightly soluble in waterexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
441.58 g/molcalc.
Exact mass
441.1392 Dacalc.
LogP (octanol/water)
1.98calc.
Topological polar surface area
104.8 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
11calc.
Heavy atoms
29calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.37calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(CCNCCOc2ccccc2)cc1

c1ccc(CCNCCOc2ccccc2)cc1

2 rings, 18 atoms, the (2-Phenoxyethyl)(2-phenylethyl)amine ring system.

95 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H302Harmful if swallowed.
  • H360May damage fertility or the unborn child.
  • H373May cause damage to organs through prolonged or repeated exposure.
  • H411Toxic to aquatic life with long lasting effects.
Precautionary statements (13)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P330Rinse mouth.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Dofetilide suppliers

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Where suppliers are based

107 suppliers in 18 countries

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Dofetilide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Anti-Arrhythmia Agents
  • Potassium Channel Blockers

Roles

  • anti-arrhythmia drug
  • biophysical role
  • cardiovascular drug
  • membrane transport modulator
  • pharmaceutical
  • potassium channel blocker
  • potassium channel modulator

Pharmacology

Dofetilide is an Antiarrhythmic.

How it is made

By nucleophilic displacement of the halogen in 4-(2-bromoethoxy)methanesulfonanilide by N-methyl-p-nitrophenethylamine and potassium carbonate in acetonitrile, the tertiary amine precursor of the product is formed. The p-nitro group is catalytically reduced to the amine, which is then sulfonated with dimethyl sulfate in methylene chloride to afford the product.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Dofetilide is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Dofetilide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Dofetilide, based on the data on this page

What is Dofetilide?

Dofetilide is a tertiary amino compound that is N-ethyl-N-methylethanamine substituted by a 4-[(methylsulfonyl)amino]phenoxy and a 4-[(methylsulfonyl)amino]phenyl group at the terminal carbon atoms respectively. It is used as an anti-arrhythmia drug.

What is the CAS number of Dofetilide?

The CAS registry number of Dofetilide is 115256-11-6.

What is the molecular formula and weight of Dofetilide?

The molecular formula of Dofetilide is C19H27N3O5S2 and its molar mass is 441.58 g/mol.

What is Dofetilide used for?

Known uses and roles of Dofetilide include cardiovascular drugs in pharmaceuticals, anti-arrhythmia drug, biophysical role, cardiovascular drug, membrane transport modulator and 5 more.

Is Dofetilide hazardous?

Dofetilide carries the GHS signal word "Danger". Main hazards: harmful if swallowed, may damage fertility or the unborn child, may cause damage to organs through prolonged or repeated exposure. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Dofetilide?

Dofetilide is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Dofetilide?

CompoundList lists 107 suppliers of Dofetilide in United States, China, India, United Kingdom and 14 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Dofetilide in India?

11 suppliers in India list Dofetilide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Dofetilide?

Suppliers quote Dofetilide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Dofetilide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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