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Antibiotics and anti-infectives

Doramectin

Also known as Doramectina, Dectomax, Doramectine

CAS 117704-25-3Formula C50H74O14Molar mass 899.13 g/molEC 601-490-4
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard, Hazardous to the environment 56 suppliers listed Drug substance
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Doramectin chemical structure, C50H74O14, CAS 117704-25-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
117704-25-3
Formula
C50H74O14
Molar mass
899.13 g/mol
Melting point
116 to 119
HS code
293220
Category
Antibiotics and anti-infectives

What is Doramectin?

Plain description, key identifiers and synonyms

doramectin has been reported in Streptomyces avermitilis.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(1'R,2R,3S,4'S,6S,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-2-cyclohexyl-21',24'-dihydroxy-12'-[(2R,4S,5S,6S)-5-[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-3,11',13',22'-tetramethylspiro[2,3-dihydropyran-6,6'-3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene]-2'-one
CAS number
117704-25-3 CAS number cross-checked
EC numbers
601-490-4, 923-471-2
Molecular formula
C50H74O14
UNII
KGD7A54H5P
MDL number
MFCD00894747
InChIKey
QLFZZSKTJWDQOS-YDBLARSUSA-N
InChI
InChI=1S/C50H74O14/c1-27-13-12-16-34-26-57-47-42(51)30(4)21-37(50(34,47)54)48(53)60-36-22-35(63-49(25-36)20-19-29(3)45(64-49)33-14-10-9-11-15-33)18-17-28(2)44(27)61-41-24-39(56-8)46(32(6)59-41)62-40-23-38(55-7)43(52)31(5)58-40/h12-13,16-17,19-21,27,29,31-33,35-47,51-52,54H,9-11,14-15,18,22-26H2,1-8H3/b13-12+,28-17+,34-16+/t27-,29-,31-,32-,35+,36-,37-,38-,39-,40-,41-,42+,43-,44-,45-,46-,47+,49+,50+/m0/s1
Canonical SMILES
COC1CC(OC2C(C)OC(OC3C(C)=CCC4CC(CC5(C=CC(C)C(C6CCCCC6)O5)O4)OC(=O)C4C=C(C)C(O)C5OCC(=CC=CC3C)C45O)CC2OC)OC(C)C1O
Isomeric SMILES
C[C@H]1/C=C/C=C/2\CO[C@H]3[C@@]2([C@@H](C=C([C@H]3O)C)C(=O)O[C@H]4C[C@@H](C/C=C(/[C@H]1O[C@H]5C[C@@H]([C@H]([C@@H](O5)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O)OC)OC)\C)O[C@]7(C4)C=C[C@@H]([C@H](O7)C8CCCCC8)C)O

Synonyms

  • Doramectina
  • Dectomax
  • Doramectine
  • Doramectinum
  • UK 67994
  • UK-67,994
  • Avermectin A1a, 25-cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)-
  • Doraject
  • DectoGard
  • Dectomax Pour-On
  • DectoGard Pour-On
  • Dectomax Pour-on Solution for Cattle
  • Dectomax Injectable Solution for Cattle and Swine
  • 25-cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)-Avermectin A1a
  • 25-cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin A1a
  • Doramecti
  • Doramectin (Standard)
  • UK 67,994
  • 25-cyclohexyl-avermectin B1
  • Cyclohexylavermectin B1, Dectomax
  • Doramectin 100 |Ig/mL in Acetonitrile
  • Doramectin 100 microg/mL in Acetonitrile
  • Doramectin Solution in Methanol, 100ug/mL
  • Doramectin Solution in Methanol, 1000ug/mL
  • Avermectin A(sub 1a), 25-cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Melting point
116 to 119exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
899.13 g/molcalc.
Exact mass
898.5079 Dacalc.
LogP (octanol/water)
5.91calc.
Topological polar surface area
170.1 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
14calc.
Rotatable bonds
7calc.
Heavy atoms
64calc.
Rings
8calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.78calc.
Formal charge
0calc.
Stereocentres
19calc.
Lipinski rule of five
Fails (3 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1OC2CC(CC=CC(OC3CCC(OC4CCCCO4)CO3)CC=CC=C3COC4CC=CC1C34)OC1(C=CCC(C3CCCCC3)O1)C2

O=C1OC2CC(CC=CC(OC3CCC(OC4CCCCO4)CO3)CC=CC=C3COC4CC=CC1C34)OC1(C=CCC(C3CCCCC3)O1)C2

8 rings, 51 atoms.

1 other chemical share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H300Fatal if swallowed.
  • H301Toxic if swallowed.
  • H302Harmful if swallowed.
  • H360May damage fertility or the unborn child.
  • H361Suspected of damaging fertility or the unborn child.
  • H362May cause harm to breast-fed children.
  • H370Causes damage to organs.
  • H372Causes damage to organs through prolonged or repeated exposure.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (17)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P263Avoid contact during pregnancy and while nursing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P301 + P317If swallowed: Get medical help.
  • P308 + P316If exposed or concerned: Get emergency medical help immediately.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Doramectin suppliers

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All 56 suppliers
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Where suppliers are based

56 suppliers in 12 countries

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Doramectin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Therapeutic category (veterinary): antiparasitic.

Control of certain gastrointestinal roundworms, lungworms, eyeworms, kidney worms, grubs, lice, and mange mites (in cattle and swine)[US FDA, Animal Drugs, Feeds, and Related Products: Doramectin. Federal Register: November 21, 1997 (Volume 62, Number 225)] [Rules and Regulations].

Veterinary medication:.

Use classes: Animal Drugs.

Pharmacological actions

  • Anthelmintics
  • Anti-Anxiety Agents
  • Anticonvulsants
  • Insecticides

Functional uses

  • Biocide

How it is made

S.P. Gibson et al., European patent 214,731, (corresponds to) US patent 5,089,480 (1987, 1992 both to Pfizer).

Fermentation product of a specific strain of Streptomyces avermitilis...

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Doramectin is traded under.

HS 2932.20Indicative HS code

Lactones

World exports in 2024
$1.97B
−4.7% vs 2023, imports $2.07B
2019 to 2024
Top exporters
  1. China56.3%
  2. India * partner reported7.4%
  3. Germany7.3%
Top importers
  1. United States14.2%
  2. India * partner reported13.5%
  3. Brazil8.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Doramectin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Doramectin, based on the data on this page

What is Doramectin?

doramectin has been reported in Streptomyces avermitilis.

What is the CAS number of Doramectin?

The CAS registry number of Doramectin is 117704-25-3.

What is the molecular formula and weight of Doramectin?

The molecular formula of Doramectin is C50H74O14 and its molar mass is 899.13 g/mol.

What is Doramectin used for?

Therapeutic category (veterinary): antiparasitic. Control of certain gastrointestinal roundworms, lungworms, eyeworms, kidney worms, grubs, lice, and mange mites (in cattle and swine)[US FDA, Animal Drugs, Feeds, and Related Products: Doramectin.

Is Doramectin hazardous?

Doramectin carries the GHS signal word "Danger". Main hazards: fatal if swallowed, toxic if swallowed, harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Doramectin?

Doramectin is usually classified under HS code 293220 (Lactones). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Doramectin?

CompoundList lists 56 suppliers of Doramectin in China, United States, Germany, United Kingdom and 8 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Doramectin in India?

1 supplier in India list Doramectin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Doramectin?

Suppliers quote Doramectin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Doramectin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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