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Cardiovascular and metabolic drugs

Edoxaban

Also known as N'-(5-chloropyridin-2-yl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-{5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine-2-amido}cyclohexyl]ethanediamide, edoxabanum, N'-(5-chloropyridin-2-yl)-N-((1S,2R,4S)-4-(dimethylcarbamoyl)-2-((5-methyl6,7-dihydro-4H-(1,3)thiazolo(5,4-c)pyridine-2-carbonyl)amino)cyclohexyl)oxamide

CAS 480449-70-5Formula C24H30ClN7O4SMolar mass 548.07 g/molEC 859-181-7
GHS signal word: Warning. Pictograms: Serious health hazard 80 suppliers listed Drug substance
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Edoxaban chemical structure, C24H30ClN7O4S, CAS 480449-70-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
480449-70-5
Formula
C24H30ClN7O4S
Appearance
White to pale yellowish-white crystalline powder
Melting point
Crystals as monohydrate from ethanol + water. MP: 245-48 (decomposes) /Edoxaban tosylate/
HS code
293499
Category
Cardiovascular and metabolic drugs
Illustrative photo, off-white crystalline powder in fibre drums in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Edoxaban?

Plain description, key identifiers and synonyms

Edoxaban is a monocarboxylic acid amide that is used (as its tosylate monohydrate) for the treatment of deep vein thrombosis and pulmonary embolism. It has a role as an anticoagulant, a platelet aggregation inhibitor and an EC 3.4.21.6 (coagulation factor Xa) inhibitor. It is a monocarboxylic acid amide, a chloropyridine, a thiazolopyridine and a tertiary amino compound. It is a conjugate base of an edoxaban(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N'-(5-chloro-2-pyridinyl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide
CAS number
480449-70-5 CAS number cross-checkedOther or deprecated CAS: 912273-65-5
EC number
859-181-7
Molecular formula
C24H30ClN7O4S
UNII
NDU3J18APO
MDL number
MFCD13195544
InChIKey
HGVDHZBSSITLCT-JLJPHGGASA-N
InChI
InChI=1S/C24H30ClN7O4S/c1-31(2)24(36)13-4-6-15(27-20(33)21(34)30-19-7-5-14(25)11-26-19)17(10-13)28-22(35)23-29-16-8-9-32(3)12-18(16)37-23/h5,7,11,13,15,17H,4,6,8-10,12H2,1-3H3,(H,27,33)(H,28,35)(H,26,30,34)/t13-,15-,17+/m0/s1
Canonical SMILES
CN1CCc2nc(C(=O)NC3CC(C(=O)N(C)C)CCC3NC(=O)C(=O)Nc3ccc(Cl)cn3)sc2C1
Isomeric SMILES
CN1CCC2=C(C1)SC(=N2)C(=O)N[C@@H]3C[C@H](CC[C@@H]3NC(=O)C(=O)NC4=NC=C(C=C4)Cl)C(=O)N(C)C

Synonyms

  • N'-(5-chloropyridin-2-yl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-{5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine-2-amido}cyclohexyl]ethanediamide
  • edoxabanum
  • N'-(5-chloropyridin-2-yl)-N-((1S,2R,4S)-4-(dimethylcarbamoyl)-2-((5-methyl6,7-dihydro-4H-(1,3)thiazolo(5,4-c)pyridine-2-carbonyl)amino)cyclohexyl)oxamide
  • N'-(5-chloropyridin-2-yl)-N-((1S,2R,4S)-4-(dimethylcarbamoyl)-2-(5-methyl-4H,5H,6H,7H-(1,3)thiazolo(5,4-c)pyridine-2-amido)cyclohexyl)ethanediamide
  • N'-(5-chloropyridin-2-yl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide
  • N-(5-chloropyridin-2-yl)-N'-((1S,2R,4S)-4-(N,N-dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydro(1,3)thiazolo(5,4-c)pyridine-2-carboxamido)cyclohexyl)oxamide
  • N-(5-chloropyridin-2-yl)-N'-[(1S,2R,4S)-4-(N,N-dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamido)cyclohexyl]oxamide
  • edoxaban tosilate hydrochloride
  • DU-176b
  • N1-(5-chloropyridin-2-yl)-N2-((1S,2R,4S)-4-(dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexyl)oxalamide
  • C24H30ClN7O4S
  • N'-(5-chloro-2-pyridinyl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide
  • N1-(5-Chloropyridin-2-yl)-N2-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexyl]oxalamide
  • 480449-70-5 (free base)
  • Edoxaban (Standard)
  • Edoxaban (USAN/INN)
  • N'-(5-chloro-2-pyridyl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide
  • N'-(5-chloropyridin-2-yl)-N-[(1s,2r,4s)-4-(dimethylcarbamoyl)-2-[(5-methyl-6,7-dihydro-4h-[1,3] thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide
  • N-(5-Chloropyridin-2-yl)-N'-((1S,2R,4S)-4-(N,N-dimethylcarbamoyl)-2-(5-methyl-4,5,6,7- tetrahydro(1,3)thiazolo(5,4-c)pyridine-2-carboxamido)cyclohexyl)oxamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White to pale yellowish-white crystalline powderexp.
Melting point
Crystals as monohydrate from ethanol + water. MP: 245-48 (decomposes) /Edoxaban tosylate/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
548.07 g/molcalc.
Exact mass
547.1769 Dacalc.
LogP (octanol/water)
1.29calc.
Topological polar surface area
136.6 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
5calc.
Heavy atoms
37calc.
Rings
4calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.5calc.
Formal charge
0calc.
Stereocentres
3calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(Nc1ccccn1)C(=O)NC1CCCCC1NC(=O)c1nc2c(s1)CNCC2

O=C(Nc1ccccn1)C(=O)NC1CCCCC1NC(=O)c1nc2c(s1)CNCC2

4 rings, 30 atoms.

31 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H373May cause damage to organs through prolonged or repeated exposure.
Precautionary statements (3)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P319Get medical help if you feel unwell.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Edoxaban suppliers

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All 80 suppliers
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Where suppliers are based

80 suppliers in 14 countries

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Edoxaban price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Factor Xa Inhibitors.

Pharmacological actions

  • Factor Xa Inhibitors

Roles

  • anti-arrhythmia drug
  • anticoagulant
  • antimicrobial agent
  • antiviral agent
  • cardiovascular drug
  • enzyme inhibitor
  • hematologic agent
  • hepatoprotective agent
  • pharmaceutical
  • platelet aggregation inhibitor
  • protective agent

Pharmacology

Edoxaban is a Factor Xa Inhibitor. The mechanism of action of edoxaban is as a Factor Xa Inhibitor.

How it is made

Preparation: T. Ohta et al., World Intellectual Property Organization patent 03000657, eidem, United States of America patent 7365205 (2003, 2008 both to Daiichi).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Edoxaban is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Edoxaban is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Edoxaban, based on the data on this page

What is Edoxaban?

Edoxaban is a monocarboxylic acid amide that is used (as its tosylate monohydrate) for the treatment of deep vein thrombosis and pulmonary embolism. It has a role as an anticoagulant, a platelet aggregation inhibitor and an EC 3.4.21.6 (coagulation factor Xa) inhibitor.

What is the CAS number of Edoxaban?

The CAS registry number of Edoxaban is 480449-70-5. Other or deprecated CAS numbers: 912273-65-5.

What is the molecular formula and weight of Edoxaban?

The molecular formula of Edoxaban is C24H30ClN7O4S and its molar mass is 548.07 g/mol.

What is Edoxaban used for?

Factor Xa Inhibitors.

Is Edoxaban hazardous?

Edoxaban carries the GHS signal word "Warning". Main hazards: may cause damage to organs through prolonged or repeated exposure. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Edoxaban?

Edoxaban is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Edoxaban?

CompoundList lists 80 suppliers of Edoxaban in United States, China, Germany, United Kingdom and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Edoxaban in India?

3 suppliers in India list Edoxaban on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Edoxaban?

Suppliers quote Edoxaban on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Edoxaban

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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