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Cardiovascular and metabolic drugs

Eipa

Also known as Ethylisopropylamiloride, 5-(Ethylisopropyl)amiloride, Ethyl isopropyl amiloride

CAS 1154-25-2Formula C11H18ClN7OMolar mass 299.77 g/molEC 634-217-2
GHS signal word: Warning. Pictograms: Harmful or irritant 24 suppliers listed
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Eipa chemical structure, C11H18ClN7O, CAS 1154-25-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1154-25-2
Formula
C11H18ClN7O
Molar mass
299.77 g/mol
EC number
634-217-2
HS code
293399
Category
Cardiovascular and metabolic drugs

What is Eipa?

Plain description, key identifiers and synonyms

Ethylisopropylamiloride is a member of the class of pyrazines that is amiloride in which the amino substitutent of the pyrazine ring that is adjacent to the chloro substituent has been substituted by an ethyl group and by an isopropyl group. It has a role as an anti-arrhythmia drug, a sodium channel blocker and a neuroprotective agent. It is a member of guanidines, a monocarboxylic acid amide, an aromatic amine, an organochlorine compound, a member of pyrazines and a tertiary amino compound. It is functionally related to an amiloride.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
3-amino-6-chloro-N-(diaminomethylidene)-5-[ethyl(propan-2-yl)amino]pyrazine-2-carboxamide
CAS number
1154-25-2 CAS number cross-checked
EC number
634-217-2
Molecular formula
C11H18ClN7O
UNII
VW50CE070T
MDL number
MFCD00151710
InChIKey
QDERNBXNXJCIQK-UHFFFAOYSA-N
InChI
InChI=1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)
SMILES (canonical and isomeric)
CCN(C1=NC(=C(N=C1Cl)C(=O)N=C(N)N)N)C(C)C

Synonyms

  • Ethylisopropylamiloride
  • 5-(Ethylisopropyl)amiloride
  • Ethyl isopropyl amiloride
  • 3-amino-6-chloro-N-(diaminomethylidene)-5-[ethyl(propan-2-yl)amino]pyrazine-2-carboxamide
  • N-Amidino-3-amino-5-ethylisopropylamino-6-chloropyrazine carboxamide
  • 3-Amino-N-(aminoiminomethyl)-6-chloro-5-(ethyl(1-methylethyl)amino)pyrazinecarboxamide
  • Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-6-chloro-5-(ethyl(1-methylethyl)amino)-
  • 3-amino-6-chloro-N-(diaminomethylidene)-5-(ethyl(propan-2-yl)amino)pyrazine-2-carboxamide
  • 5-(N-Ethyl-N-isopropyl)amiloride
  • 3-Amino-N-carbamimidoyl-6-chloro-5-(ethyl(isopropyl)amino)pyrazine-2-carboxamide
  • 3-Amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-2-pyrazinecarboxamide
  • 3-amino-N-carbamimidoyl-6-chloro-5-[ethyl(isopropyl)amino]pyrazine-2-carboxamide
  • 2-Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-
  • 5-(N-ethyl-N-isopropyl)-Amiloride
  • Ethylisopropyl amiloride
  • 2-Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-6-chloro-5-(ethyl(1-methylethyl)amino)-
  • 3-amino-6-chloro-n-(diaminomethylene)-5-[ethyl(isopropyl)amino]pyrazine-2-carboxamide
  • REGID_for_CID_1795
  • EIPA (L593754)
  • 5''-(N-ethyl-N-isopropyl)amiloride
  • N-Amidino-3-amino-5-ethylisopropylami
  • Sdccgsbi-0050034.p002
  • 3-amino-N-carbamimidoyl-6-chloro-5-[ethyl(propan-2-yl)amino]pyrazine-2-carboxamide
  • {3-amino-6-chloro-5-[ethyl(methylethyl)amino]pyrazin-2-yl}-N-(???methyl)carbox amide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
299.77 g/molcalc.
Exact mass
299.1261 Dacalc.
LogP (octanol/water)
0.36calc.
Topological polar surface area
136.5 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
4calc.
Heavy atoms
20calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.46calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1cnccn1

c1cnccn1

1 ring, 6 atoms, the Pyrazine ring system.

6,118 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Eipa suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 24 suppliers
24 of 24 offers
  • Cool Pharm Co., Ltd.
    China, ShanghaiUnclaimed profile
    EipaGrade, purity and minimum order on request
    Price on request
    View
  • 1st Scientific LLC
    China, NanjingUnclaimed profile
    EipaGrade, purity and minimum order on request
    Price on request
    View
  • Abmole Bioscience Inc.
    United States, HoustonUnclaimed profile
    EipaGrade, purity and minimum order on request
    Price on request
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  • Acmec Biochemical
    China, ShanghaiUnclaimed profile
    EipaGrade, purity and minimum order on request
    Price on request
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  • AiFChem
    United States, SomervilleUnclaimed profile
    EipaGrade, purity and minimum order on request
    Price on request
    View
  • Ambeed, Inc.
    United States, Buffalo GroveUnclaimed profile
    EipaGrade, purity and minimum order on request
    Price on request
    View
  • Ambinter
    France, OrleansUnclaimed profile
    EipaGrade, purity and minimum order on request
    Price on request
    View
  • BioCrick
    China, ChengduUnclaimed profile
    EipaGrade, purity and minimum order on request
    Price on request
    View
  • Chemenu. Inc.
    China, ShanghaiUnclaimed profile
    EipaGrade, purity and minimum order on request
    Price on request
    View
  • Cooke Chemical Co., Ltd.
    China, FuxinUnclaimed profile
    EipaGrade, purity and minimum order on request
    Price on request
    View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

24 suppliers in 6 countries

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Eipa price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Acid Sensing Ion Channel Blockers
  • Anti-Arrhythmia Agents
  • Epithelial Sodium Channel Blockers
  • Neuroprotective Agents

Roles

  • anti-arrhythmia drug
  • biophysical role
  • cardiovascular drug
  • membrane transport modulator
  • neuroprotective agent
  • pharmaceutical
  • protective agent
  • sodium channel blocker
  • sodium channel modulator

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Eipa is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Eipa is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Eipa, based on the data on this page

What is Eipa?

Ethylisopropylamiloride is a member of the class of pyrazines that is amiloride in which the amino substitutent of the pyrazine ring that is adjacent to the chloro substituent has been substituted by an ethyl group and by an isopropyl group.

What is the CAS number of Eipa?

The CAS registry number of Eipa is 1154-25-2.

What is the molecular formula and weight of Eipa?

The molecular formula of Eipa is C11H18ClN7O and its molar mass is 299.77 g/mol.

What is Eipa used for?

Known uses and roles of Eipa include cardiovascular drugs in pharmaceuticals, anti-arrhythmia drug, biophysical role, cardiovascular drug, membrane transport modulator and 9 more.

Is Eipa hazardous?

Eipa carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Eipa?

Eipa is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Eipa?

CompoundList lists 24 suppliers of Eipa in China, United States, France, United Kingdom and 2 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Eipa?

Suppliers quote Eipa on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Eipa

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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