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Antibiotics and anti-infectives

Ethambutol

Also known as Ethambutolum, (+)-ethambutol, Aethambutolum

CAS 74-55-5Formula C10H24N2O2Molar mass 204.31 g/molEC 200-810-6
GHS signal word: Warning. Pictograms: Harmful or irritant, Serious health hazard 58 suppliers listed Drug substance
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Ethambutol chemical structure, C10H24N2O2, CAS 74-55-5
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals
Melting point
87.5 to 88.8
Solubility
Soluble in chloroform, methylene chloride, less soluble in benzene, sparingly soluble in…
HS code
292219
Category
Antibiotics and anti-infectives
Illustrative photo, 25 kg white woven sacks of powder on a pallet in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Ethambutol?

Plain description, key identifiers and synonyms

Ethambutol is an ethylenediamine derivative that is ethane-1,2-diamine in which one hydrogen attached to each of the nitrogens is sutstituted by a 1-hydroxybutan-2-yl group (S,S-configuration). It is a bacteriostatic antimycobacterial drug, effective against Mycobacterium tuberculosis and some other mycobacteria. It is used (as the dihydrochloride salt) in combination with other antituberculous drugs in the treatment of pulmonary and extrapulmonary tuberculosis, resistant strains of M. tuberculosis are readily produced if ethambutol is used alone. It has a role as an antitubercular agent, a xenobiotic and an environmental contaminant. It is a member of ethanolamines and an ethylenediamine derivative.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S)-2-[2-[[(2S)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol
CAS number
74-55-5 CAS number cross-checkedOther or deprecated CAS: 36697-71-9
EC number
200-810-6
Molecular formula
C10H24N2O2
UNII
8G167061QZ
InChIKey
AEUTYOVWOVBAKS-UWVGGRQHSA-N
InChI
InChI=1S/C10H24N2O2/c1-3-9(7-13)11-5-6-12-10(4-2)8-14/h9-14H,3-8H2,1-2H3/t9-,10-/m0/s1
Canonical SMILES
CCC(CO)NCCNC(CC)CO
Isomeric SMILES
CC[C@@H](CO)NCCN[C@@H](CC)CO

Synonyms

  • Ethambutolum
  • (+)-ethambutol
  • Aethambutolum
  • Diambutol
  • D-Ethambutol
  • (+)-S,S-Ethambutol
  • (S,S)-ethambutol
  • Etambutolo
  • S,S-Ethambutol
  • (+)-2,2'-(Ethylenediimino)di-1-butanol
  • (2S)-2-[2-[[(2S)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol
  • (+)-N,N'-Bis(1-(hydroxymethyl)propyl)ethylenediamine
  • D-2,2'-(Ethylenediimino)di-1-butanol
  • D-2,2'-(Ethylenediimino)bis(1-butanol)
  • 1-Butanol, 2,2'-(ethylenediimino)di-, (+)-
  • D-N,N'-Bis(1-hydroxymethylpropyl)ethylenediamine
  • (2S,7S)-2,7-diethyl-3,6-diazaoctane-1,8-diol
  • 1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, (S-(R*,R*))-
  • (2S)-2-[(2-{[(2S)-1-hydroxybutan-2-yl]amino}ethyl)amino]butan-1-ol
  • 1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, (R-(R*,R*))-
  • (2S)-2-((2-(((2S)-1-hydroxybutan-2-yl)amino)ethyl)amino)butan-1-ol
  • (2S)-2-(2-(((2S)-1-hydroxybutan-2-yl)amino)ethylamino)butan-1-ol
  • EMB Hefa
  • Llorente, Etambutol
  • Etambutol
Show all 34 synonyms
  • (2S,2'S)-2,2'-(Ethane-1,2-diylbis(azanediyl))bis(butan-1-ol)
  • EMB
  • Purderal
  • DivK1c_000561
  • Ethambutol (INN)
  • (2R)-2-[2-(1-hydroxybutan-2-ylamino)ethylamino]butan-1-ol
  • 1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, (2S,2'S)-
  • (2S,2'S)-2,2'-(ethane-1,2-diyldiimino)dibutan-1-ol
  • (2S)-2-[2-[[(1S)-1-(hydroxymethyl)propyl]amino]ethylamino]butan-1-ol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystalsexp.
Odour
ESSENTIALLY ODORLESSexp.
Taste
HAS BITTER TASTEexp.
Melting point
87.5 to 88.8exp.
Solubility
Soluble in chloroform, methylene chloride, less soluble in benzene, sparingly soluble in waterexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
204.31 g/molcalc.
Exact mass
204.1838 Dacalc.
LogP (octanol/water)
-0.29calc.
Topological polar surface area
64.52 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
9calc.
Heavy atoms
14calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H373May cause damage to organs through prolonged or repeated exposure.
Precautionary statements (7)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P319Get medical help if you feel unwell.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Ethambutol suppliers

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All 58 suppliers
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Where suppliers are based

58 suppliers in 12 countries

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Ethambutol price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Used to treat atypical mycobacteria, M. kansasii ... M. avium-intracellularis ... a tuberculostatic agent active against most human strains of tubercle bacilli (Hydrochloride).

Therapeutic category: Antibacterial (tuberculostatic).

Pharmacological actions

  • Antitubercular Agents

Roles

  • anti-inflammatory agent
  • antibacterial agent
  • antibacterial drug
  • antiinfective agent
  • antimicrobial agent
  • antimicrobial drug
  • antimycobacterial drug
  • antitubercular agent
  • environmental contaminant
  • pharmaceutical
  • xenobiotic

Pharmacology

Ethambutol is an Antimycobacterial.

How it is made

(+-)-2-Aminobutanol is resolved via its tartrate and (+)-enantiomorph is condensed with 1,2-dichloroethane in an appropriate dehydrochlorinating environment. Ethambutol thus formed is dissolved in suitable solvent & reacted with hcl. (Ethambutol hydrochloride)

Prepd by heating ethylene dichloride with (+)-2-aminobutanol or, alternatively, by alkylating 2-aminobutanol with glyoxal using nabh4 as reducing agent.

2-Aminobutanol + glyoxal (racemate separation/reductive amination)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Ethambutol is traded under.

HS 2922.19Indicative HS code

Amino-alcohols, other than those containing more than one kind of oxygen function, their…

World exports in 2024
$2.2B
−4.7% vs 2023, imports $2.27B
2019 to 2024
Top exporters
  1. China21.7%
  2. Germany17.3%
  3. United States15.6%
Top importers
  1. India * partner reported11.0%
  2. United States9.0%
  3. Germany7.2%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Ethambutol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Ethambutol, based on the data on this page

What is Ethambutol?

Ethambutol is an ethylenediamine derivative that is ethane-1,2-diamine in which one hydrogen attached to each of the nitrogens is sutstituted by a 1-hydroxybutan-2-yl group (S,S-configuration). It is a bacteriostatic antimycobacterial drug, effective against Mycobacterium tuberculosis and some other mycobacteria.

What is the CAS number of Ethambutol?

The CAS registry number of Ethambutol is 74-55-5. Other or deprecated CAS numbers: 36697-71-9.

What is the molecular formula and weight of Ethambutol?

The molecular formula of Ethambutol is C10H24N2O2 and its molar mass is 204.31 g/mol.

What is Ethambutol used for?

Used to treat atypical mycobacteria, M. kansasii ... M. avium-intracellularis ... a tuberculostatic agent active against most human strains of tubercle bacilli (Hydrochloride). Therapeutic category: Antibacterial (tuberculostatic).

Is Ethambutol hazardous?

Ethambutol carries the GHS signal word "Warning". Main hazards: harmful if swallowed, may cause damage to organs through prolonged or repeated exposure. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Ethambutol?

Ethambutol is usually classified under HS code 292219 (Amino-alcohols, other than those containing more than one kind of oxygen function, their…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Ethambutol?

CompoundList lists 58 suppliers of Ethambutol in United States, China, India, United Kingdom and 8 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Ethambutol in India?

10 suppliers in India list Ethambutol on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Ethambutol?

Suppliers quote Ethambutol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Ethambutol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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