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Cardiovascular and metabolic drugs

Ethoxzolamide

Also known as 6-Ethoxy-2-benzothiazolesulfonamide, Ethoxyzolamide, Ethoxazolamide

CAS 452-35-7Formula C9H10N2O3S2Molar mass 258.32 g/molEC 207-199-5
GHS signal word: Warning. Pictograms: Harmful or irritant 21 suppliers listed
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Ethoxzolamide chemical structure, C9H10N2O3S2, CAS 452-35-7
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from ethyl acetate + skellysolve b
Melting point
188 to 190.5
Solubility
SLIGHTLY SOL IN ALC, ACETONE, CHLOROFORM & ETHER, PRACTICALLY INSOL IN WATER
HS code
293590
Category
Cardiovascular and metabolic drugs
Illustrative photo, closed blue fibre drums on a pallet in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Ethoxzolamide?

Plain description, key identifiers and synonyms

Ethoxzolamide is a sulfonamide that is 1,3-benzothiazole-2-sulfonamide which is substituted by an ethoxy group at position 6. A carbonic anhydrase inhibitor, it has been used in the treatment of glaucoma, and as a diuretic. It has a role as an EC 4.2.1.1 (carbonic anhydrase) inhibitor, a diuretic and an antiglaucoma drug. It is a sulfonamide, an aromatic ether and a member of benzothiazoles.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
6-ethoxy-1,3-benzothiazole-2-sulfonamide
CAS number
452-35-7 CAS number cross-checked
EC number
207-199-5
Molecular formula
C9H10N2O3S2
UNII
Z52H4811WX
MDL number
MFCD00057089
InChIKey
OUZWUKMCLIBBOG-UHFFFAOYSA-N
InChI
InChI=1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13)
SMILES (canonical and isomeric)
CCOC1=CC2=C(C=C1)N=C(S2)S(=O)(=O)N

Synonyms

  • 6-Ethoxy-2-benzothiazolesulfonamide
  • Ethoxyzolamide
  • Ethoxazolamide
  • Ethamide
  • Cardrase
  • 6-Ethoxy-1,3-benzothiazole-2-sulfonamide
  • Etoxzolamide
  • Glaucotensil
  • Diuretic C
  • Mingoral
  • 2-Benzothiazolesulfonamide, 6-ethoxy-
  • 6-Ethoxyzolamide
  • 6-Ethoxybenzo[d]thiazole-2-sulfonamide
  • 6-Ethoxybenzothiazole-2-sulfonamide
  • Redupresin, L-643786, PNU-4191
  • 6-Ethoxy-benzothiazole-2-sulfonic acid amide
  • Redupresin
  • 6-Ethoxybenzothiazole-2-sulphonamide
  • Cardrase (TN)
  • EZL
  • Athamid
  • 3caj
  • 3dcw
  • 3mdz
  • EZA
Show all 31 synonyms
  • Ethoxzolamide, EZM
  • 3dd0
  • 6-(ethyloxy)-1,3-benzothiazole-2-sulfonamide
  • 4-27-00-04404 (Beilstein Handbook Reference)
  • Ethoxzolamide (1265005)
  • 6-ethoxy-2-benzothiazole sulfonamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from ethyl acetate + skellysolve bexp.
Odour
ODORLESSexp.
Melting point
188 to 190.5exp.
Solubility
SLIGHTLY SOL IN ALC, ACETONE, CHLOROFORM & ETHER, PRACTICALLY INSOL IN WATERexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
258.32 g/molcalc.
Exact mass
258.0133 Dacalc.
LogP (octanol/water)
1.34calc.
Topological polar surface area
82.28 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
3calc.
Heavy atoms
16calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.22calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2scnc2c1

c1ccc2scnc2c1

2 rings, 9 atoms, the Benzothiazole ring system.

6,032 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Ethoxzolamide suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 21 suppliers
21 of 21 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

21 suppliers in 5 countries

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Ethoxzolamide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Pharmacological actions

  • Carbonic Anhydrase Inhibitors
  • Diuretics

Roles

  • antiglaucoma drug
  • diuretic
  • enzyme inhibitor
  • ophthalmology drug
  • pharmaceutical

Pharmacology

Ethoxzolamide is a sulfonamide and carbonic anhydrase (CA) inhibitor with diuretic and anti-glaucoma activity. In the eye, ethoxzolamide inhibits CA, thereby decreasing the secretion of aqueous humor. This may relieve intraocular pressure. Also, this agent prevents reabsorption of bicarbonate and sodium in the proximal convoluted tubule thereby producing a mild diuresis.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Ethoxzolamide is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Ethoxzolamide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Ethoxzolamide, based on the data on this page

What is Ethoxzolamide?

Ethoxzolamide is a sulfonamide that is 1,3-benzothiazole-2-sulfonamide which is substituted by an ethoxy group at position 6. A carbonic anhydrase inhibitor, it has been used in the treatment of glaucoma, and as a diuretic.

What is the CAS number of Ethoxzolamide?

The CAS registry number of Ethoxzolamide is 452-35-7.

What is the molecular formula and weight of Ethoxzolamide?

The molecular formula of Ethoxzolamide is C9H10N2O3S2 and its molar mass is 258.32 g/mol.

What is Ethoxzolamide used for?

Known uses and roles of Ethoxzolamide include antihypertensives in pharmaceuticals, antiglaucoma drug, diuretic, enzyme inhibitor, ophthalmology drug and 3 more.

Is Ethoxzolamide hazardous?

Ethoxzolamide carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Ethoxzolamide?

Ethoxzolamide is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Ethoxzolamide?

CompoundList lists 21 suppliers of Ethoxzolamide in United States, China, United Kingdom, Hong Kong and 1 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Ethoxzolamide?

Suppliers quote Ethoxzolamide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Ethoxzolamide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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