Faricimab
Also known as faricimabum, Vabysmo, faricimab-svoa
Key facts
What buyers check first
- CAS number
- 1607793-29-2
- Formula
- C25H30ClN3O2
- Molar mass
- 439.99 g/mol
- HS code
- 293499
- Category
- Oncology and immunology drugs
What is Faricimab?
Plain description, key identifiers and synonyms
Faricimab is a humanized bispecific antibody targeting both vascular endothelial growth factor A (VEGF-A) and angiopoietin-2 (Ang-2, Ang2, ANGPT2), that is used for the treatment of neovascular (wet) age-related macular degeneration and diabetic macular edema. Upon intravitreal administration, faricimab targets and binds to both VEGF-A and Ang-2, and prevents VEGF-A- and Ang-2-mediated signaling. The inhibition of VEGF-A-mediated signaling decreases endothelial cell proliferation, neovascularization and vascular permeability. The inhibition of Ang-2-mediated signaling improves vascular stability and desensitizes blood vessels to the effects of VEGF-A. VEGF and Ang-2, upregulated in some eye diseases, play important roles in pathological neovascularization and increased vascular permeability and inflammation, which may lead to vision loss.
Identifiers
Registry numbers, names and line notations, tap to copy
- IUPAC name
- [6-chloro-1-[2-(dimethylamino)ethyl]-2,3-dihydroindol-3-yl]-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone
- CAS number
- 1607793-29-2
- Molecular formula
- C25H30ClN3O2
- InChIKey
- DRMVDBATNZBNEB-UHFFFAOYSA-N
- InChI
- InChI=1S/C25H30ClN3O2/c1-27(2)13-14-29-16-21(20-8-7-19(26)15-23(20)29)24(30)28-11-9-25(10-12-28)22-6-4-3-5-18(22)17-31-25/h3-8,15,21H,9-14,16-17H2,1-2H3
- SMILES (canonical and isomeric)
- CN(C)CCN1CC(C2=C1C=C(C=C2)Cl)C(=O)N3CCC4(CC3)C5=CC=CC=C5CO4
Synonyms
- faricimabum
- Vabysmo
- faricimab-svoa
- Y8ha1i28d3
- RG-7716 (antivascular endothelial growth factor/anti-angiopoietin 2 bispecific antibody)
Physical and chemical properties
Measured values and descriptors computed from the structure
Physical and chemical properties
Measured values, check the supplier specification for your grade
No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.
Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.
Computed descriptors
Calculated from the structure, useful for screening and formulation
| Molecular weight | 439.99 g/molcalc.Computed value |
|---|---|
| Exact mass | 439.2027 Dacalc.Computed value |
| LogP (octanol/water) | 3.85calc.Computed value |
| Topological polar surface area | 36.02 Ųcalc.Computed value |
| Hydrogen bond donors | 0calc.Computed value |
| Hydrogen bond acceptors | 4calc.Computed value |
| Rotatable bonds | 4calc.Computed value |
| Heavy atoms | 31calc.Computed value |
| Rings | 5calc.Computed value |
| Aromatic rings | 2calc.Computed value |
| Fraction sp3 carbons | 0.48calc.Computed value |
| Formal charge | 0calc.Computed value |
| Stereocentres | 1calc.Computed value |
| Lipinski rule of five | Passes (0 violations)calc.Computed value |
Calculated for screening. Confirm critical figures with the supplier.
Murcko scaffold
The ring system that remains when every side chain is removed
O=C(C1CNc2ccccc21)N1CCC2(CC1)OCc1ccccc12
5 rings, 25 atoms.
No other chemical in our database has this scaffold.
Safety and hazards
GHS classification summary, not a safety data sheet
No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.
GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.
Faricimab suppliers
Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings
Post one free request and suppliers who make or trade Faricimab can send you quotes. Your contact details stay private until you accept a quote.
Faricimab price
Indicative price range per kg from live supplier offers
Suppliers quote this chemical on request. Send one free request and compare quotes side by side.
Uses and applications
What the substance is used for, by industry and function
Industries and functions
Pharmacological actions
- Angiogenesis Inhibitors
Regulatory status
Inventories, regulations and trade controls that list this substance
Health and food
- Active ingredient in FDA approved drug labels
HS code and trade data
Customs classification and reported world trade statistics
Global trade
World import and export statistics for the HS code Faricimab is traded under.
Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934
- United States24.5%
- Germany23.1%
- Japan4.5%
The HS code shown for Faricimab is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.
Related chemicals
Parent and salt forms, stereoisomers, similar structures and isomers
Same formula isomers
Different compounds that share this molecular formula
![1-tert-Butyl-4-{1-[4-(4-chlorophenoxy)butyl]-1H-1,3-benzodiazol-2-yl}pyrrolidin-2-one chemical structure, C25H30ClN3O2, CAS 878693-64-2](/s/HCUNIPXDAAYSAZ-UHFFFAOYSA-N.svg)
![1-tert-Butyl-4-{1-[3-(4-chloro-3-methylphenoxy)propyl]-1H-benzimidazol-2-yl}pyrrolidin-2-one chemical structure, C25H30ClN3O2, CAS 939332-54-4](/s/KTEMSOOIKWCOFH-UHFFFAOYSA-N.svg)
![8-{[5-(Diethylamino)pentyl]amino}quinolin-6-yl 4-chlorobenzoate chemical structure, C25H30ClN3O2, CAS 6633-12-1](/s/SYJJHKDQZZSKLP-UHFFFAOYSA-N.svg)
Frequently asked questions
Quick answers about Faricimab, based on the data on this page
What is Faricimab?
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What is the molecular formula and weight of Faricimab?
What is Faricimab used for?
Is Faricimab hazardous?
What is the HS code of Faricimab?
Where can I buy Faricimab?
What is the price of Faricimab?
Guides for buyers
Practical guides that help when you source, ship or handle Faricimab
- Article, QualityPharma grades explained: IP vs BP vs USP vs EPWhat the Indian, British, US and European pharmacopoeias are, how their monographs differ, what multi grade claims mean and why a grade alone does not make a product fit for medicines.Read
- Article, SourcingHow to write an RFQ that gets fast and accurate quotesWhat suppliers need to quote quickly and comparably: exact product identity, quantity and packing, delivery terms, documents, samples and payment, with a ready to use template.Read
- Guide, Trade and logisticsHS codes for chemicals and why they matterHow the Harmonized System classifies chemicals, the chapters that matter, the rules for chemically defined compounds and mixtures, and practical steps to find the right code.Read
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