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Cardiovascular and metabolic drugs

Fasudil

Also known as ha-1077, Fasudilum, 1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-

CAS 103745-39-7Formula C14H17N3O2SMolar mass 291.38 g/molEC 816-154-4
GHS signal word: Warning. Pictograms: Harmful or irritant 58 suppliers listed
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Fasudil chemical structure, C14H17N3O2S, CAS 103745-39-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
103745-39-7
Formula
C14H17N3O2S
Molar mass
291.38 g/mol
EC number
816-154-4
HS code
293590
Category
Cardiovascular and metabolic drugs

What is Fasudil?

Plain description, key identifiers and synonyms

Fasudil is an isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia. It has a role as a geroprotector, a vasodilator agent, an antihypertensive agent, a calcium channel blocker, an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor, a neuroprotective agent and a nootropic agent. It is a member of isoquinolines and a N-sulfonyldiazepane. It is a conjugate base of a fasudil(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
5-(1,4-diazepan-1-ylsulfonyl)isoquinoline
CAS number
103745-39-7 CAS number cross-checked
EC number
816-154-4
Molecular formula
C14H17N3O2S
UNII
Q0CH43PGXS
MDL number
MFCD00866182
InChIKey
NGOGFTYYXHNFQH-UHFFFAOYSA-N
InChI
InChI=1S/C14H17N3O2S/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14/h1,3-5,7,11,15H,2,6,8-10H2
SMILES (canonical and isomeric)
C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3

Synonyms

  • ha-1077
  • Fasudilum
  • 1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-
  • HA 1077
  • AT 877
  • 1-(5-Isoquinolinesulfonyl)homopiperazine
  • Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine
  • 5-[(Hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]isoquinoline
  • 5-((Hexahydro-1H-1,4-diazepin-1-yl)sulfonyl)isoquinoline
  • 5-(1,4-diazepane-1-sulfonyl)isoquinoline
  • 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline
  • HA-1077 (hydrochloride)
  • 5-((1,4-diazepan-1-yl)sulfonyl)isoquinoline
  • 5-(1,4-Diazepan-1-sulfonyl)isoquinoline
  • Fasudil (INN)
  • Hexahydro-1-(5-isoquinolylsulfonyl)-1H-1,4-diazepine
  • 1-(5-Isoquinoline-sulfonyl)-homopiperazine
  • Fasudil?
  • 2esm
  • 2gni
  • dihydrochloride fasudil
  • Fasudil Impurity 49
  • Kinome_3390
  • Kinome_3391
  • Tocris-0541
Show all 29 synonyms
  • 1q8w
  • BiomolKI2_000046
  • Fasudil (HA-1077)
  • Bio2_000386

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
291.38 g/molcalc.
Exact mass
291.1041 Dacalc.
LogP (octanol/water)
1.22calc.
Topological polar surface area
62.3 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
2calc.
Heavy atoms
20calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.36calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=S(=O)(c1cccc2cnccc12)N1CCCNCC1

O=S(=O)(c1cccc2cnccc12)N1CCCNCC1

3 rings, 20 atoms. This chemical is the scaffold itself.

35 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Fasudil suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 58 suppliers
30 of 30 offers
  • api-chem.com
    ChinaUnclaimed profile
    FasudilGrade, purity and minimum order on request
    Price on request
    View
  • 10X Chem
    United States, San DiegoUnclaimed profile
    FasudilGrade, purity and minimum order on request
    Price on request
    View
  • A2B Chem LLC
    United States, San DiegoUnclaimed profile
    FasudilGrade, purity and minimum order on request
    Price on request
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  • Aa Blocks LLC
    United States, San DiegoUnclaimed profile
    FasudilGrade, purity and minimum order on request
    Price on request
    View
  • Aaron Chemicals LLC.
    China, NanjingUnclaimed profile
    FasudilGrade, purity and minimum order on request
    Price on request
    View
  • AbaChemScene, LLC
    United States, Monmouth JunctionUnclaimed profile
    FasudilGrade, purity and minimum order on request
    Price on request
    View
  • ABCR GmbH & CO. KG
    GermanyUnclaimed profile
    FasudilGrade, purity and minimum order on request
    Price on request
    View
  • Abmole Bioscience Inc.
    United States, HoustonUnclaimed profile
    FasudilGrade, purity and minimum order on request
    Price on request
    View
  • Accel Scientific S.L.
    Spain, BarcelonaUnclaimed profile
    FasudilGrade, purity and minimum order on request
    Price on request
    View
  • Accela ChemBio Inc.
    United States, San DiegoUnclaimed profile
    FasudilGrade, purity and minimum order on request
    Price on request
    View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

58 suppliers in 11 countries

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Fasudil price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Calcium Channel Blockers
  • Protein Kinase Inhibitors
  • Vasodilator Agents

Roles

  • antagonist
  • antihypertensive agent
  • biophysical role
  • calcium channel blocker
  • calcium channel modulator
  • cardiovascular drug
  • enzyme inhibitor
  • geroprotector
  • membrane transport modulator
  • neuroprotective agent
  • nootropic agent
  • pharmaceutical
  • protective agent
  • protein kinase inhibitor
  • vasodilator agent

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Fasudil is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Fasudil is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Fasudil, based on the data on this page

What is Fasudil?

Fasudil is an isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.

What is the CAS number of Fasudil?

The CAS registry number of Fasudil is 103745-39-7.

What is the molecular formula and weight of Fasudil?

The molecular formula of Fasudil is C14H17N3O2S and its molar mass is 291.38 g/mol.

What is Fasudil used for?

Known uses and roles of Fasudil include antihypertensives in pharmaceuticals, cardiovascular drugs in pharmaceuticals, anticancer drugs in pharmaceuticals, biochemical and pharmacological tools in research and laboratory, antagonist and 17 more.

Is Fasudil hazardous?

Fasudil carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Fasudil?

Fasudil is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Fasudil?

CompoundList lists 58 suppliers of Fasudil in United States, China, United Kingdom, Germany and 7 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Fasudil?

Suppliers quote Fasudil on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Fasudil

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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