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Analgesics and anti-inflammatories

Flufenamic acid

Also known as Arlef, Fluphenamic acid, Achless

CAS 530-78-9Formula C14H10F3NO2Molar mass 281.23 g/molEC 208-494-1
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Hazardous to the environment 93 suppliers listed
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Flufenamic acid chemical structure, C14H10F3NO2, CAS 530-78-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
530-78-9
Formula
C14H10F3NO2
Molar mass
281.23 g/mol
EC number
208-494-1
HS code
292249
Category
Analgesics and anti-inflammatories

What is Flufenamic acid?

Plain description, key identifiers and synonyms

Flufenamic acid is an aromatic amino acid consisting of anthranilic acid carrying an N-(trifluoromethyl)phenyl substituent. An analgesic and anti-inflammatory, it is used in rheumatic disorders. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic and an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor. It is an aromatic amino acid and an organofluorine compound. It is functionally related to an anthranilic acid, a (trifluoromethyl)benzene and a diphenylamine. It is a conjugate acid of a flufenamate.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-[3-(trifluoromethyl)anilino]benzoic acid
CAS number
530-78-9 CAS number cross-checked
EC number
208-494-1
Molecular formula
C14H10F3NO2
UNII
60GCX7Y6BH
MDL number
MFCD00002422
InChIKey
LPEPZBJOKDYZAD-UHFFFAOYSA-N
InChI
InChI=1S/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20)
SMILES (canonical and isomeric)
C1=CC=C(C(=C1)C(=O)O)NC2=CC=CC(=C2)C(F)(F)F

Synonyms

  • Arlef
  • Fluphenamic acid
  • Achless
  • 2-((3-(Trifluoromethyl)phenyl)amino)benzoic acid
  • N-(3-Trifluoromethylphenyl)anthranilic acid
  • Acido flufenamico
  • Flufenaminsaeure
  • Meralen
  • 2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid
  • Acide flufenamique
  • 2-[3-(Trifluoromethyl)anilino]benzoic acid
  • CI 440
  • Acidum flufenamicum
  • 2-[[3-(Trifluoromethyl)phenyl]amino]benzoic acid
  • CN-27,554
  • 3'-Trifluoromethyldiphenylamine-2-carboxylic acid
  • Benzoic acid, 2-[[3-(trifluoromethyl)phenyl]amino]-
  • Benzoic acid, 2-((3-(trifluoromethyl)phenyl)amino)-
  • N-(alpha,alpha,alpha-Trifluoro-m-tolyl)anthranilic acid
  • Acid, Flufenamic
  • 2-(3-(trifluoromethyl)anilino)benzoic acid
  • flufenamic acid aluminium
  • Fullsafe
  • Nichisedan
  • Tecramine
Show all 38 synonyms
  • Paraflu
  • Parlef
  • Flufacid
  • Lanceat
  • Plostene
  • Parlif
  • Surika
  • Reumajust A
  • Ristogen
  • Sastridex
  • Ansatin
  • Fluore-200
  • TVX 916

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
281.23 g/molcalc.
Exact mass
281.0664 Dacalc.
LogP (octanol/water)
4.15calc.
Topological polar surface area
49.33 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
3calc.
Heavy atoms
20calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.07calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(Nc2ccccc2)cc1

c1ccc(Nc2ccccc2)cc1

2 rings, 13 atoms, the Diphenylamine ring system.

3,181 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H301Toxic if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
  • H411Toxic to aquatic life with long lasting effects.
Precautionary statements (21)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Flufenamic acid suppliers

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All 93 suppliers
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Where suppliers are based

93 suppliers in 16 countries

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Flufenamic acid price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Pharmacological actions

  • Anti-Inflammatory Agents

Roles

  • analgesic
  • anti-inflammatory agent
  • anti-inflammatory drug
  • antipyretic
  • antirheumatic drug
  • enzyme inhibitor
  • non-narcotic analgesic
  • non-steroidal anti-inflammatory drug
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Flufenamic acid is traded under.

HS 2922.49Indicative HS code

Amino-acids, other than those containing more than one kind of oxygen function, and…

World exports in 2024
$3.88B
−11.5% vs 2023, imports $3.87B
2019 to 2024
Top exporters
  1. China38.7%
  2. India * partner reported8.3%
  3. Germany8.1%
Top importers
  1. United States13.4%
  2. Germany11.1%
  3. Japan6.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Flufenamic acid is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Flufenamic acid, based on the data on this page

What is Flufenamic acid?

Flufenamic acid is an aromatic amino acid consisting of anthranilic acid carrying an N-(trifluoromethyl)phenyl substituent. An analgesic and anti-inflammatory, it is used in rheumatic disorders.

What is the CAS number of Flufenamic acid?

The CAS registry number of Flufenamic acid is 530-78-9.

What is the molecular formula and weight of Flufenamic acid?

The molecular formula of Flufenamic acid is C14H10F3NO2 and its molar mass is 281.23 g/mol.

What is Flufenamic acid used for?

Use classes: Pharmaceuticals.

Is Flufenamic acid hazardous?

Flufenamic acid carries the GHS signal word "Danger". Main hazards: toxic if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Flufenamic acid?

Flufenamic acid is usually classified under HS code 292249 (Amino-acids, other than those containing more than one kind of oxygen function, and…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Flufenamic acid?

CompoundList lists 93 suppliers of Flufenamic acid in United States, China, Germany, United Kingdom and 12 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Flufenamic acid?

Suppliers quote Flufenamic acid on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Flufenamic acid

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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