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Antibiotics and anti-infectives

Fumagillin

Also known as Fugillin, Fumidil, Amebacilin

CAS 23110-15-8Formula C26H34O7Molar mass 458.55 g/molEC 245-433-8
GHS signal word: Warning. Pictograms: Harmful or irritant 35 suppliers listed Drug substance
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Fumagillin chemical structure, C26H34O7, CAS 23110-15-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
23110-15-8
Formula
C26H34O7
Molar mass
458.55 g/mol
EC number
245-433-8
HS code
291719
Category
Antibiotics and anti-infectives

What is Fumagillin?

Plain description, key identifiers and synonyms

Fumagillin is a meroterpenoid resulting from the formal condensation of the hydroxy group of fumagillol with the carboxylic acid group of (all-E)-deca-2,4,6,8-tetraenedioic acid. Originally isolated from the fungus Aspergillus fumigatus, it is used for the control of Nosema infection in honey bees. It has a role as an antimicrobial agent, an antiprotozoal drug, an antibacterial drug, an angiogenesis inhibitor, a methionine aminopeptidase 2 inhibitor and a fungal metabolite. It is a spiro-epoxide, an organooxygen heterocyclic antibiotic, a carboxylic ester, a dicarboxylic acid monoester, a meroterpenoid and an antibiotic antifungal drug. It is functionally related to a fumagillol and an (all-E)-deca-2,4,6,8-tetraenedioic acid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2E,4E,6E,8E)-10-[[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl]oxy]-10-oxodeca-2,4,6,8-tetraenoic acid
CAS number
23110-15-8 CAS number cross-checkedOther or deprecated CAS: 127913-45-5
EC number
245-433-8
Molecular formula
C26H34O7
UNII
7OW73204U1
MDL number
MFCD03990453
InChIKey
NGGMYCMLYOUNGM-CSDLUJIJSA-N
InChI
InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+/t19-,20-,23-,24-,25+,26+/m1/s1
Canonical SMILES
COC1C(OC(=O)C=CC=CC=CC=CC(=O)O)CCC2(CO2)C1C1(C)OC1CC=C(C)C
Isomeric SMILES
CC(=CC[C@@H]1[C@@](O1)(C)[C@H]2[C@@H]([C@@H](CC[C@]23CO3)OC(=O)/C=C/C=C/C=C/C=C/C(=O)O)OC)C

Synonyms

  • Fugillin
  • Fumidil
  • Amebacilin
  • Fumagilina
  • Fumagilline
  • Fumagillinum
  • Fumagillina
  • 2,4,6,8-Decatetraenedioic acid, 4-(1,2-epoxy-1,5-dimethyl-4-hexenyl)-5-methoxy-1-oxaspiro(2,5)oct-6-yl ester
  • 2,4,6,8-Decatetraenedioic acid, mono((3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl)-1-oxaspiro(2.5)oct-6-yl) ester, (2E,4E,6E,8E)-
  • Fumidil-B
  • (-)-Fumagillin
  • Fugilin
  • Amebacillin
  • Fumagillin DCH
  • Flisint
  • Fumagillin?
  • Fumagillin (Standard)
  • (2E,4E,6E,8E)-10-(((3R,4S,5S,6R)-5-Methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl)oxy)-10-oxodeca-2,4,6,8-tetraeno
  • Fumagillin Solution in Acetonitrile, 100ug/mL
  • (2E,4E,6E,8E)-Mono[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1- oxaspiro[2.5]oct-6-yl] 2,4,6,8-decatetraenedioic acid ester
  • (2E,4E,6E,8E)-Mono[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl] 2,4,6,8-deca tetraenedioic acid ester
  • 2,4,6,8-decatetraenedioic acid, 4-(1,2-epoxy-1,5-dimethyl-4-hexenyl)-5-methoxy-1-oxaspiro(2,5)oct-6-yl ester, Fumagillin
  • 2,4,6,8-Decatetraenedioic acid, mono(4-(1,2-epoxy-1,5-dimethyl-4-hexenyl)-5-methoxy-1-oxaspiro(2.5)oct-6-yl) ester
  • 2,4,6,8-Decatetraenedioic acid, mono(4-(1,2-epoxy-1,5-dimethyl-4-hexenyl)-5-methoxy-1-oxaspiro(2.5)oct-6-yl) ester (VAN)
  • 2,4,6,8-Decatetraenedioic acid, mono(5-methoxy-4-(2-methyl-3-(3-methyl-2-butenyl)oxiranyl)-1-oxaspiro(2.5)oct-6-yl) ester, (3R-(3alp
Show all 26 synonyms
  • Antibiotic obtained from cultures of Aspergillus fumigatus, or the same substance produced by any other means

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
458.55 g/molcalc.
Exact mass
458.2305 Dacalc.
LogP (octanol/water)
3.92calc.
Topological polar surface area
97.89 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
10calc.
Heavy atoms
33calc.
Rings
3calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.54calc.
Formal charge
0calc.
Stereocentres
6calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1CCC2(CO2)C(C2CO2)C1

C1CCC2(CO2)C(C2CO2)C1

3 rings, 11 atoms.

14 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Fumagillin suppliers

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All 35 suppliers
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Where suppliers are based

35 suppliers in 10 countries

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Fumagillin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Angiogenesis Inhibitors
  • Anti-Bacterial Agents
  • Antiprotozoal Agents

Roles

  • angiogenesis inhibitor
  • antibacterial agent
  • antibacterial drug
  • antiinfective agent
  • antimicrobial agent
  • antimicrobial drug
  • antiparasitic agent
  • antiprotozoal drug
  • enzyme inhibitor
  • eukaryotic metabolite
  • fungal metabolite
  • metabolite
  • methionine aminopeptidase 2 inhibitor
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Fumagillin is traded under.

HS 2917.19Indicative HS code

Acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and…

World exports in 2024
$718M
+8.1% vs 2023, imports $915M
2019 to 2024
Top exporters
  1. China46.6%
  2. United States13.7%
  3. Germany10.1%
Top importers
  1. United States16.2%
  2. Denmark11.8%
  3. Germany10.0%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Fumagillin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Fumagillin, based on the data on this page

What is Fumagillin?

Fumagillin is a meroterpenoid resulting from the formal condensation of the hydroxy group of fumagillol with the carboxylic acid group of (all-E)-deca-2,4,6,8-tetraenedioic acid. Originally isolated from the fungus Aspergillus fumigatus, it is used for the control of Nosema infection in honey bees.

What is the CAS number of Fumagillin?

The CAS registry number of Fumagillin is 23110-15-8. Other or deprecated CAS numbers: 127913-45-5.

What is the molecular formula and weight of Fumagillin?

The molecular formula of Fumagillin is C26H34O7 and its molar mass is 458.55 g/mol.

What is Fumagillin used for?

Known uses and roles of Fumagillin include antibacterials and antibiotics in pharmaceuticals, anticancer drugs in pharmaceuticals, angiogenesis inhibitor, antibacterial agent, antibacterial drug and 14 more.

Is Fumagillin hazardous?

Fumagillin carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Fumagillin?

Fumagillin is usually classified under HS code 291719 (Acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Fumagillin?

CompoundList lists 35 suppliers of Fumagillin in United States, China, Germany, United Kingdom and 6 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Fumagillin?

Suppliers quote Fumagillin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Fumagillin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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