Gluconic acid
Also known as D-gluconic acid, dextronic acid, maltonic acid
Key facts
What buyers check first
- Appearance
- Needles from ethanol & ether
- Melting point
- 131 °C
- Density
- 1.23 g/cm³
- Solubility
- FREELY SOL IN WATER, SLIGHTLY SOL IN ALC, INSOLUBLE IN ETHER AND MOST OTHER ORGANIC SOLV…
- HS code
- 291816
- Category
- Synthetic aroma chemicals

What is Gluconic acid?
Plain description, key identifiers and synonyms
D-gluconic acid is a gluconic acid having D-configuration. It has a role as a chelator and a Penicillium metabolite. It is a conjugate acid of a D-gluconate. It is an enantiomer of a L-gluconic acid.
Gluconic acid is a product of glucose oxidation.
Identifiers
Registry numbers, names and line notations, tap to copy
- IUPAC name
- (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid
- CAS number
- 526-95-4 CAS number cross-checkedOther or deprecated CAS: 124423-64-9, 133-42-6
- EC number
- 208-401-4
- Molecular formula
- C6H12O7
- UNII
- R4R8J0Q44B
- MDL number
- MFCD00004240
- INCI name
- GLUCONIC ACID
- InChIKey
- RGHNJXZEOKUKBD-SQOUGZDYSA-N
- InChI
- InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/t2-,3-,4+,5-/m1/s1
- Canonical SMILES
- O=C(O)C(O)C(O)C(O)C(O)CO
- Isomeric SMILES
- C([C@H]([C@H]([C@@H]([C@H](C(=O)O)O)O)O)O)O
Synonyms
- D-gluconic acid
- dextronic acid
- maltonic acid
- Glycogenic acid
- (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid
- Glosanto
- Pentahydroxycaproic acid
- D-Gluco-hexonic acid
- INS NO.574
- GlyTouCan:G12678RQ
- Gluconic acid, D-
- Hexonic acid
- Gluconic acid (VAN)
- D-Gluconsaeure
- D-Glukonsaeure
- D-Gluconic Acid (50% in Water)
- Glyconic acid
- Dextronate
- Glycogenate
- Glyconate
- Maltonate
- GCO
- sodium-gluconate
- ketogluconic acid
- D-?Gluconic acid
Show all 32 synonymsShow fewer synonyms
- Pentahydroxycaproate
- (2R,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanoic acid (45-50% in Water)
- L-glycero-Hexonic acid
- Gluconal ga-50
- 4-03-00-01255 (Beilstein Handbook Reference)
- D-Gluconic acid 50% in water
- GluconicAcid(containsGluconolactone)
Physical and chemical properties
Measured values and descriptors computed from the structure
Physical and chemical properties
Measured values, check the supplier specification for your grade
| Appearance | Needles from ethanol & etherexp.Measured value |
|---|---|
| Taste | MILD ACID TASTEexp.Measured value |
| Melting point | 131 °Cexp.Measured value |
| Density | 1.23 g/cm³exp.Measured value |
| Solubility | FREELY SOL IN WATER, SLIGHTLY SOL IN ALC, INSOLUBLE IN ETHER AND MOST OTHER ORGANIC SOLVENTSexp.Measured value |
Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.
Computed descriptors
Calculated from the structure, useful for screening and formulation
| Molecular weight | 196.16 g/molcalc.Computed value |
|---|---|
| Exact mass | 196.0583 Dacalc.Computed value |
| LogP (octanol/water) | -3.49calc.Computed value |
| Topological polar surface area | 138.5 Ųcalc.Computed value |
| Hydrogen bond donors | 6calc.Computed value |
| Hydrogen bond acceptors | 6calc.Computed value |
| Rotatable bonds | 5calc.Computed value |
| Heavy atoms | 13calc.Computed value |
| Rings | 0calc.Computed value |
| Aromatic rings | 0calc.Computed value |
| Fraction sp3 carbons | 0.83calc.Computed value |
| Formal charge | 0calc.Computed value |
| Stereocentres | 4calc.Computed value |
| Lipinski rule of five | Passes (1 violation)calc.Computed value |
Calculated for screening. Confirm critical figures with the supplier.
Safety and hazards
GHS classification summary, not a safety data sheet
Hazard statements
- H315Causes skin irritation.
- H319Causes serious eye irritation.
Precautionary statements (9)
- P264Wash skin thoroughly after handling.
- P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
- P280Wear protective gloves, protective clothing, eye protection and face protection.
- P302 + P352If on skin: Wash with plenty of water.
- P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P321Specific treatment (see supplemental first aid instructions on the label).
- P332 + P317If skin irritation occurs: Get medical help.
- P337 + P317If eye irritation persists: Get medical help.
- P362 + P364Take off contaminated clothing. And wash it before reuse.
GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.
Full safety data and first aidGluconic acid suppliers
Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings
- China, NantongUnclaimed profileGluconic AcidGrade, purity and minimum order on requestPrice on request
- United States, WayneUnclaimed profileGluconic AcidGrade, purity and minimum order on requestPrice on request
- Germany, HamburgUnclaimed profileGluconic AcidGrade, purity and minimum order on requestPrice on request
- Netherlands, HilversumUnclaimed profileD-Gluconic AcidGrade, purity and minimum order on requestPrice on request
- Austria, Wien ManufacturerUnclaimed profileGluconic AcidGrade, purity and minimum order on requestPrice on request
- China ManufacturerUnclaimed profileGluconic AcidGrade, purity and minimum order on requestPrice on request
- ChinaUnclaimed profileGluconic AcidGrade, purity and minimum order on requestPrice on request
- ChinaUnclaimed profileGluconic AcidGrade, purity and minimum order on requestPrice on request
- Price on request
- Price on request
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Where suppliers are based
141 suppliers in 29 countries
- United States43
- China30
- India11
- Germany7
- United Kingdom5
- Spain4
- and 23 more countries
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Gluconic acid price
Indicative price range per kg from live supplier offers
Suppliers quote this chemical on request. Send one free request and compare quotes side by side.
Uses and applications
What the substance is used for, by industry and function
The active ingredient is no longer contained in any registered pesticide products ... "cancelled.".
In dairy indust to prevent milkstone, in breweries to prevent beerstone, latent acid catalyst for acid colloid resins, particularly in textile printing component of many cleaning compounds... (Gluconolactone).
In pharmaceutical & food products, cleaning & pickling metals, sequestrant.
Industrial uses: Anti-scaling agent, Intermediate, Chelating agent, pH regulating agent, Plating agent, Processing aids not otherwise specified.
Consumer uses: Processing aids not otherwise specified, pH regulating agent, Anti-scaling agent, Intermediate, Chelating agent.
Use classes: Chelating Agents, Processing Aids and Additives, Safer Chemical Classes, Food additives, Cosmetics.
Industries and functions
Cosmetic ingredient, INCI name GLUCONIC ACID(chelating, perfuming)
Roles
- Penicillium metabolite
- chelator
- eukaryotic metabolite
- fungal metabolite
- ligand
- metabolite
Functional uses
- Chelating agent
- Flavouring and nutrient
- Fragrance
- Humectant
- Pharmaceutical
- Processing aids not otherwise specified
- Solvent
- pH regulating agent
Cosmetic functions
- Chelating
- Perfuming
Pharmacology
Gluconic Acid is the carboxylic acid formed by the oxidation of the first carbon of glucose with antiseptic and chelating properties. Gluconic acid, found abundantly in plant, honey and wine, can be prepared by fungal fermentation process commercially. This agent and its derivatives can used in formulation of pharmaceuticals, cosmetics and food products as additive or buffer salts. Aqueous gluconic acid solution contains cyclic ester glucono delta lactone structure, which chelates metal ions and forms very stable complexes. In alkaline solution, this agent exhibits strong chelating activities towards anions, i.e. calcium, iron, aluminium, copper, and other heavy metals.
How it is made
May be prepared from glucose by electrolytic oxidn in alkaline medium, by chem oxidn with hypobromites
By hydrolysis of alpha-d-glucose with bromine plus h2so4, by gamma-irradiation of d-glucose.
At present produced in commercial quantities by fermentative oxidn of aldehyde group in glucose from corn using aspergillus niger, aspergillus fumaricus, acetobacter aceti, penicillium chrysogenum, & other penicillia.
Regulatory status
Inventories, regulations and trade controls that list this substance
Health and food
- EU cosmetic ingredient inventory
- Food additive
United States
- Safer Choice ingredient list (USA)
- TSCA inventory (USA)Status: Active in US commerce
HS code and trade data
Customs classification and reported world trade statistics
Global trade
World import and export statistics for the HS code Gluconic acid is traded under.
Gluconic acid, its salts and esters
- China64.9%
- France * partner reported12.1%
- Netherlands4.8%
- India * partner reported14.1%
- United States6.0%
- Portugal5.1%
* Partner reported figures, a lower bound.
The HS code shown for Gluconic acid is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.
Frequently asked questions
Quick answers about Gluconic acid, based on the data on this page
What is Gluconic acid?
What is the CAS number of Gluconic acid?
What is the molecular formula and weight of Gluconic acid?
What is Gluconic acid used for?
Is Gluconic acid hazardous?
What is the HS code of Gluconic acid?
Where can I buy Gluconic acid?
Where can I buy Gluconic acid in India?
What is the price of Gluconic acid?
Guides for buyers
Practical guides that help when you source, ship or handle Gluconic acid
- Guide, SafetyHow to read a safety data sheet in 10 minutesA section by section method to pull the essentials out of any 16 section SDS: identity, hazards, composition, storage, PPE, properties, transport and emergency measures.Read
- Guide, SafetyGHS pictograms, signal words and hazard statements explainedA practical guide to the nine GHS pictograms, the signal words Danger and Warning, H and P statements, and how to read a chemical label in seconds.Read
- Article, FormulationHow to choose a cosmetic emulsifierA structured way to choose an emulsifier for creams and lotions: emulsion type, HLB and its limits, emulsifier families, formula fit, stability testing and what to ask suppliers.Read
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