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Gluconic acid

Also known as D-gluconic acid, dextronic acid, maltonic acid

Gluconic acid chemical structure, C6H12O7, CAS 526-95-4
2D chemical structure

Key facts

What buyers check first

Appearance
Needles from ethanol & ether
Melting point
131 °C
Density
1.23 g/cm³
Solubility
FREELY SOL IN WATER, SLIGHTLY SOL IN ALC, INSOLUBLE IN ETHER AND MOST OTHER ORGANIC SOLV…
HS code
291816
Category
Synthetic aroma chemicals
Illustrative photo, drums, an IBC tote and sacks in a chemical warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Gluconic acid?

Plain description, key identifiers and synonyms

D-gluconic acid is a gluconic acid having D-configuration. It has a role as a chelator and a Penicillium metabolite. It is a conjugate acid of a D-gluconate. It is an enantiomer of a L-gluconic acid.

Gluconic acid is a product of glucose oxidation.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid
CAS number
526-95-4 CAS number cross-checkedOther or deprecated CAS: 124423-64-9, 133-42-6
EC number
208-401-4
Molecular formula
C6H12O7
UNII
R4R8J0Q44B
MDL number
MFCD00004240
INCI name
GLUCONIC ACID
InChIKey
RGHNJXZEOKUKBD-SQOUGZDYSA-N
InChI
InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/t2-,3-,4+,5-/m1/s1
Canonical SMILES
O=C(O)C(O)C(O)C(O)C(O)CO
Isomeric SMILES
C([C@H]([C@H]([C@@H]([C@H](C(=O)O)O)O)O)O)O

Synonyms

  • D-gluconic acid
  • dextronic acid
  • maltonic acid
  • Glycogenic acid
  • (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid
  • Glosanto
  • Pentahydroxycaproic acid
  • D-Gluco-hexonic acid
  • INS NO.574
  • GlyTouCan:G12678RQ
  • Gluconic acid, D-
  • Hexonic acid
  • Gluconic acid (VAN)
  • D-Gluconsaeure
  • D-Glukonsaeure
  • D-Gluconic Acid (50% in Water)
  • Glyconic acid
  • Dextronate
  • Glycogenate
  • Glyconate
  • Maltonate
  • GCO
  • sodium-gluconate
  • ketogluconic acid
  • D-?Gluconic acid
Show all 32 synonyms
  • Pentahydroxycaproate
  • (2R,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanoic acid (45-50% in Water)
  • L-glycero-Hexonic acid
  • Gluconal ga-50
  • 4-03-00-01255 (Beilstein Handbook Reference)
  • D-Gluconic acid 50% in water
  • GluconicAcid(containsGluconolactone)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Needles from ethanol & etherexp.
Taste
MILD ACID TASTEexp.
Melting point
131 °Cexp.
Density
1.23 g/cm³exp.
Solubility
FREELY SOL IN WATER, SLIGHTLY SOL IN ALC, INSOLUBLE IN ETHER AND MOST OTHER ORGANIC SOLVENTSexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
196.16 g/molcalc.
Exact mass
196.0583 Dacalc.
LogP (octanol/water)
-3.49calc.
Topological polar surface area
138.5 Ųcalc.
Hydrogen bond donors
6calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
5calc.
Heavy atoms
13calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.83calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
Precautionary statements (9)
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Gluconic acid suppliers

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All 141 suppliers
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Where suppliers are based

141 suppliers in 29 countries

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Gluconic acid price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

The active ingredient is no longer contained in any registered pesticide products ... "cancelled.".

In dairy indust to prevent milkstone, in breweries to prevent beerstone, latent acid catalyst for acid colloid resins, particularly in textile printing component of many cleaning compounds... (Gluconolactone).

In pharmaceutical & food products, cleaning & pickling metals, sequestrant.

Industrial uses: Anti-scaling agent, Intermediate, Chelating agent, pH regulating agent, Plating agent, Processing aids not otherwise specified.

Consumer uses: Processing aids not otherwise specified, pH regulating agent, Anti-scaling agent, Intermediate, Chelating agent.

Use classes: Chelating Agents, Processing Aids and Additives, Safer Chemical Classes, Food additives, Cosmetics.

Cosmetic ingredient, INCI name GLUCONIC ACID(chelating, perfuming)

Roles

  • Penicillium metabolite
  • chelator
  • eukaryotic metabolite
  • fungal metabolite
  • ligand
  • metabolite

Functional uses

  • Chelating agent
  • Flavouring and nutrient
  • Fragrance
  • Humectant
  • Pharmaceutical
  • Processing aids not otherwise specified
  • Solvent
  • pH regulating agent

Cosmetic functions

  • Chelating
  • Perfuming

Pharmacology

Gluconic Acid is the carboxylic acid formed by the oxidation of the first carbon of glucose with antiseptic and chelating properties. Gluconic acid, found abundantly in plant, honey and wine, can be prepared by fungal fermentation process commercially. This agent and its derivatives can used in formulation of pharmaceuticals, cosmetics and food products as additive or buffer salts. Aqueous gluconic acid solution contains cyclic ester glucono delta lactone structure, which chelates metal ions and forms very stable complexes. In alkaline solution, this agent exhibits strong chelating activities towards anions, i.e. calcium, iron, aluminium, copper, and other heavy metals.

How it is made

May be prepared from glucose by electrolytic oxidn in alkaline medium, by chem oxidn with hypobromites

By hydrolysis of alpha-d-glucose with bromine plus h2so4, by gamma-irradiation of d-glucose.

At present produced in commercial quantities by fermentative oxidn of aldehyde group in glucose from corn using aspergillus niger, aspergillus fumaricus, acetobacter aceti, penicillium chrysogenum, & other penicillia.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • Food additive

United States

  • Safer Choice ingredient list (USA)
  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Gluconic acid is traded under.

HS 2918.16Exact HS code

Gluconic acid, its salts and esters

World exports in 2024
$273M
+2.4% vs 2023, imports $297M
2019 to 2024
Top exporters
  1. China64.9%
  2. France * partner reported12.1%
  3. Netherlands4.8%
Top importers
  1. India * partner reported14.1%
  2. United States6.0%
  3. Portugal5.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Gluconic acid is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Gluconic acid, based on the data on this page

What is Gluconic acid?

D-gluconic acid is a gluconic acid having D-configuration. It has a role as a chelator and a Penicillium metabolite. It is a conjugate acid of a D-gluconate. It is an enantiomer of a L-gluconic acid.

What is the CAS number of Gluconic acid?

The CAS registry number of Gluconic acid is 526-95-4. Other or deprecated CAS numbers: 124423-64-9, 133-42-6.

What is the molecular formula and weight of Gluconic acid?

The molecular formula of Gluconic acid is C6H12O7 and its molar mass is 196.16 g/mol.

What is Gluconic acid used for?

The active ingredient is no longer contained in any registered pesticide products ... "cancelled.". In dairy indust to prevent milkstone, in breweries to prevent beerstone, latent acid catalyst for acid colloid resins, particularly in textile printing component of many cleaning compounds... (Gluconolactone).

Is Gluconic acid hazardous?

Gluconic acid carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Gluconic acid?

Gluconic acid is usually classified under HS code 291816 (Gluconic acid, its salts and esters). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Gluconic acid?

CompoundList lists 141 suppliers of Gluconic acid in United States, China, India, Germany and 25 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Gluconic acid in India?

11 suppliers in India list Gluconic acid on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Gluconic acid?

Suppliers quote Gluconic acid on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Gluconic acid

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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