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Pharmaceuticals and APIs

Guanabenz acetate

Also known as Wytensin, WY-8678 acetate, Guanabenz monoacetate

CAS 23256-50-0Formula C10H12Cl2N4O2Molar mass 291.14 g/molEC 245-534-7
GHS signal word: Danger. Pictograms: Acute toxicity (severe) 51 suppliers listed Drug substance
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Guanabenz acetate chemical structure, C10H12Cl2N4O2, CAS 23256-50-0
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
White solid from acetonitrile
Melting point
227 to 229
Solubility
In water, 11 mg/ml @ 25 °C
HS code
292529
Category
Pharmaceuticals and APIs
Illustrative photo, 25 kg kraft paper sacks of white powder in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Guanabenz acetate?

Plain description, key identifiers and synonyms

Guanabenz acetate is a dichlorobenzene. It has a role as a geroprotector.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
acetic acid, 2-[(E)-(2,6-dichlorophenyl)methylideneamino]guanidine
CAS number
23256-50-0Other or deprecated CAS: 60329-04-6
EC number
245-534-7
Molecular formula
C10H12Cl2N4O2
UNII
443O19GK1A
MDL number
MFCD00153801
InChIKey
MCSPBPXATWBACD-GAYQJXMFSA-N
InChI
InChI=1S/C8H8Cl2N4.C2H4O2/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12;1-2(3)4/h1-4H,(H4,11,12,14);1H3,(H,3,4)/b13-4+;
Canonical SMILES
CC(=O)O.NC(N)=NN=Cc1c(Cl)cccc1Cl
Isomeric SMILES
CC(=O)O.C1=CC(=C(C(=C1)Cl)/C=N/N=C(N)N)Cl

Synonyms

  • Wytensin
  • WY-8678 acetate
  • Guanabenz monoacetate
  • Hydrazinecarboximidamide, 2-((2,6-dichlorophenyl)methylene)-, monoacetate
  • (E)-1-(2,6-Dichlorobenzylideneamino)guanidine monoacetate
  • 3-((2,6-Dichlorophenyl)methylene)carbazamidine monoacetate
  • Acetate, Guanabenz
  • Monoacetate, Guanabenz
  • Guanabenz Acetate Wyeth-Ayerst
  • Acetate Wyeth-Ayerst, Guanabenz
  • Wyeth Ayerst of Guanabenz Acetate
  • Wyeth-Ayerst of Guanabenz Acetate
  • Guanabenz (Acetate)
  • Guanabenz acetate salt
  • acetic acid, 2-[(E)-(2,6-dichlorophenyl)methylideneamino]guanidine
  • Hydrazinecarboximidamide, 2-[(2,6-dichlorophenyl)methylene]-, acetate (1:1)
  • (E)-2-(2,6-Dichlorobenzylidene)hydrazinecarboximidamide acetate
  • 2-(2,6-Dichlorobenzylidene)hydrazine-1-carboximidamide acetate
  • acetic acid, 2-[(Z)-(2,6-dichlorophenyl)methylideneamino]guanidine
  • ((2,6-Dichlorobenzylidene)amino)guanidine monoacetate
  • 1-[(E)-[(2,6-dichlorophenyl)methylidene]amino]guanidine, acetic acid
  • WY 8678 acetate
  • BR-750, Wy8678 acetate
  • [(2,6-Dichlorobenzylidene)amino]guanidine monoacetate
  • Wytensin (TN)
Show all 31 synonyms
  • BR 750
  • Guanabenzacetate
  • Guanabenz acetate salt, powder
  • Guanabenz (Acetate) (Standard)
  • Guanabenz acetate (JP18/USP)
  • Guanabenz (WY-8678) Acetate

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White solid from acetonitrileexp.
Odour
Slight odorexp.
Melting point
227 to 229exp.
Solubility
In water, 11 mg/ml @ 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
291.14 g/molcalc.
Exact mass
290.0337 Dacalc.
LogP (octanol/water)
1.69calc.
Topological polar surface area
114.1 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
2calc.
Heavy atoms
18calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.1calc.
Formal charge
0calc.
Stereocentres
0calc.
Components
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H301Toxic if swallowed.
Precautionary statements (7)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Guanabenz acetate suppliers

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All 51 suppliers
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Where suppliers are based

51 suppliers in 11 countries

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Guanabenz acetate price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • geroprotector
  • pharmaceutical
  • protective agent

Pharmacology

Guanabenz Acetate is the orally bioavailable, acetate salt form of guanabenz, a centrally-acting alpha-2 adrenergic receptor agonist, with anti-hypertensive and potential antineoplastic, cytoprotective and bone resorption inhibitory activities. Upon oral administration, guanabenz suppresses endoplasmic reticulum (ER) stress by inhibiting the stress-induced dephosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2a), thereby enhancing the phosphorylation level of eIF2a.

Read more

This causes elF2a-mediated downregulation of the Rac1 pathway, upregulates the expression of activating transcription factor 4 (ATF4), which plays a key role in osteoblastogenesis, and downregulates the expression of nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), which is a transcription factor that plays a key role in osteoclastogenesis. This enhances osteoblastogenesis and suppresses osteoclastogenesis. Altogether, this promotes new bone formation and prevents bone degradation. In addition, guanabenz blocks the proliferation, survival, motility and invasiveness of tumor cells through the eIF2a-mediated downregulation of Rac1 signaling. Rac1, a Ras-related small GTPase belonging to the Rho family, plays a key role in tumor cell proliferation, survival and motility.

How it is made

Preparation: J. Yates, E. Haddock, GB 1019120 (1966 to Schell) ... Use as antihypertensive: W. J. Houlihan et al, DE 1804634 (1969 to Sandoz). (Guanabenz)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Guanabenz acetate is traded under.

HS 2925.29Indicative HS code

Imines and their derivatives, salts thereof, other

World exports in 2024
$1.8B
+12.4% vs 2023, imports $1.84B
2019 to 2024
Top exporters
  1. China35.9%
  2. France * partner reported15.5%
  3. Germany9.1%
Top importers
  1. United States13.3%
  2. China13.0%
  3. Brazil9.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Guanabenz acetate is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Guanabenz acetate, based on the data on this page

What is Guanabenz acetate?

Guanabenz acetate is a dichlorobenzene. It has a role as a geroprotector.

What is the CAS number of Guanabenz acetate?

The CAS registry number of Guanabenz acetate is 23256-50-0. Other or deprecated CAS numbers: 60329-04-6.

What is the molecular formula and weight of Guanabenz acetate?

The molecular formula of Guanabenz acetate is C10H12Cl2N4O2 and its molar mass is 291.14 g/mol.

What is Guanabenz acetate used for?

Known uses and roles of Guanabenz acetate include geroprotector, pharmaceutical and protective agent.

Is Guanabenz acetate hazardous?

Guanabenz acetate carries the GHS signal word "Danger". Main hazards: toxic if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Guanabenz acetate?

Guanabenz acetate is usually classified under HS code 292529 (Imines and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Guanabenz acetate?

CompoundList lists 51 suppliers of Guanabenz acetate in United States, China, United Kingdom, Germany and 7 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Guanabenz acetate?

Suppliers quote Guanabenz acetate on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Guanabenz acetate

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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