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Cardiovascular and metabolic drugs

Guanfacine

Also known as N-carbamimidoyl-2-(2,6-dichlorophenyl)acetamide, Guanfacina, N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide

CAS 29110-47-2Formula C9H9Cl2N3OMolar mass 246.10 g/molEC 249-442-8
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Serious health hazard, Hazardous to the environment 59 suppliers listed Drug substance
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Guanfacine chemical structure, C9H9Cl2N3O, CAS 29110-47-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
29110-47-2
Formula
C9H9Cl2N3O
Molar mass
246.10 g/mol
EC number
249-442-8
HS code
292529
Category
Cardiovascular and metabolic drugs

What is Guanfacine?

Plain description, key identifiers and synonyms

Guanfacine is a member of acetamides.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide
CAS number
29110-47-2 CAS number cross-checked
EC number
249-442-8
Molecular formula
C9H9Cl2N3O
UNII
30OMY4G3MK
MDL number
MFCD00865944
InChIKey
INJOMKTZOLKMBF-UHFFFAOYSA-N
InChI
InChI=1S/C9H9Cl2N3O/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13/h1-3H,4H2,(H4,12,13,14,15)
SMILES (canonical and isomeric)
C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl

Synonyms

  • N-carbamimidoyl-2-(2,6-dichlorophenyl)acetamide
  • Guanfacina
  • N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide
  • Guanfacinum
  • Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-
  • N-amidino-2-(2,6-dichlorophenyl)acetamide
  • Estulic
  • Guanfacine (INN)
  • Guanfacine hydrochloride (Salt/Mix)
  • SPD 503
  • Estulic (TN)
  • Tenex (Salt/Mix)
  • GUANF
  • Estulic (Salt/Mix)
  • Tocris-1030
  • LON 798 (Salt/Mix)
  • (2,6-dichlorophenylacetyl)-guanidine
  • [(2,6-dichlorophenyl)acetyl]guanidine
  • Sdccgsbi-0050502.p002
  • N-(diaminomethylene)-2-(2,6-dichlorophenyl)acetamide
  • N-(Diaminomethyliden)-2-(2,6-dichlorophenyl)acetamid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
246.10 g/molcalc.
Exact mass
245.0123 Dacalc.
LogP (octanol/water)
1.34calc.
Topological polar surface area
81.47 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
2calc.
Heavy atoms
15calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.11calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H301Toxic if swallowed.
  • H361Suspected of damaging fertility or the unborn child.
  • H373May cause damage to organs through prolonged or repeated exposure.
  • H411Toxic to aquatic life with long lasting effects.
Precautionary statements (14)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Guanfacine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 59 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

59 suppliers in 14 countries

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Guanfacine price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Pharmacological actions

  • Adrenergic alpha-2 Receptor Agonists
  • Antihypertensive Agents

Roles

  • antidepressant
  • antihypertensive agent
  • cardiovascular drug
  • central nervous system drug
  • pharmaceutical
  • psychotropic drug

Pharmacology

Guanfacine is a Central alpha-2 Adrenergic Agonist. The mechanism of action of guanfacine is as an Adrenergic alpha2-Agonist.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Guanfacine is traded under.

HS 2925.29Indicative HS code

Imines and their derivatives, salts thereof, other

World exports in 2024
$1.8B
+12.4% vs 2023, imports $1.84B
2019 to 2024
Top exporters
  1. China35.9%
  2. France * partner reported15.5%
  3. Germany9.1%
Top importers
  1. United States13.3%
  2. China13.0%
  3. Brazil9.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Guanfacine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Guanfacine, based on the data on this page

What is Guanfacine?

Guanfacine is a member of acetamides.

What is the CAS number of Guanfacine?

The CAS registry number of Guanfacine is 29110-47-2.

What is the molecular formula and weight of Guanfacine?

The molecular formula of Guanfacine is C9H9Cl2N3O and its molar mass is 246.10 g/mol.

What is Guanfacine used for?

Known uses and roles of Guanfacine include antihypertensives in pharmaceuticals, antidepressant, antihypertensive agent, cardiovascular drug, central nervous system drug and 4 more.

Is Guanfacine hazardous?

Guanfacine carries the GHS signal word "Danger". Main hazards: toxic if swallowed, suspected of damaging fertility or the unborn child, may cause damage to organs through prolonged or repeated exposure. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Guanfacine?

Guanfacine is usually classified under HS code 292529 (Imines and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Guanfacine?

CompoundList lists 59 suppliers of Guanfacine in United States, China, Germany, Spain and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Guanfacine in India?

1 supplier in India list Guanfacine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Guanfacine?

Suppliers quote Guanfacine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Guanfacine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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