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Alkaloids

Harman

Also known as Harmane, 1-Methyl-9H-pyrido[3,4-b]indole, Aribine

CAS 486-84-0Formula C12H10N2Molar mass 182.23 g/molEC 207-642-2
GHS signal word: Warning. Pictograms: Harmful or irritant 48 suppliers listed
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Harman chemical structure, C12H10N2, CAS 486-84-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
486-84-0
Formula
C12H10N2
Molar mass
182.23 g/mol
EC number
207-642-2
HS code
293979
Category
Alkaloids

What is Harman?

Plain description, key identifiers and synonyms

Harman is an indole alkaloid fundamental parent with a structure of 9H-beta-carboline carrying a methyl substituent at C-1. It has been isolated from the bark of Sickingia rubra, Symplocus racemosa, Passiflora incarnata, Peganum harmala, Banisteriopsis caapi and Tribulus terrestris, as well as from tobacco smoke. It is a specific, reversible inhibitor of monoamine oxidase A. It has a role as an EC 1.4.3.4 (monoamine oxidase) inhibitor, an anti-HIV agent and a plant metabolite. It is an indole alkaloid fundamental parent, an indole alkaloid and a harmala alkaloid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-methyl-9H-pyrido[3,4-b]indole
CAS number
486-84-0 CAS number cross-checkedOther or deprecated CAS: 1189461-56-0
EC number
207-642-2
Molecular formula
C12H10N2
UNII
82D6J0535P
MDL number
MFCD00004957
InChIKey
PSFDQSOCUJVVGF-UHFFFAOYSA-N
InChI
InChI=1S/C12H10N2/c1-8-12-10(6-7-13-8)9-4-2-3-5-11(9)14-12/h2-7,14H,1H3
SMILES (canonical and isomeric)
CC1=NC=CC2=C1NC3=CC=CC=C23

Synonyms

  • Harmane
  • 1-Methyl-9H-pyrido[3,4-b]indole
  • Aribine
  • Locuturine
  • Loturine
  • Aribin
  • Locuturin
  • Passiflorin
  • 1-Methylnorharman
  • 1-Methyl-beta-carboline
  • 9H-Pyrido[3,4-b]indole, 1-methyl-
  • 1-methyl-2-carboline
  • 9H-Pyrido(3,4-b)indole, 1-methyl-
  • 1-Methyl-9H-pyrido(3,4-b)indole
  • 1-Methyl-9H-beta-carboline
  • 3-Methyl-4-carboline
  • Pyridobindole, L-methyl-
  • methylbeta-carboline
  • 1-Methyl-9H-beta-carboline #
  • 1-Methyl-9H-pyrid(3,4-b)indole
  • Zygofabagine
  • 1-Methyl-9H-pyrid[3,4-b]indole
  • Passiflorine
  • Harmane, free base
  • Harmane (Standard)
Show all 33 synonyms
  • L-methylpyridobindole
  • 2-Methyl-b-carboline
  • Harmane, 98%
  • L-Methyl-Pyridobindole
  • Tocris-1132
  • Passiflorin-13C2,15N
  • 5-23-08-00261 (Beilstein Handbook Reference)
  • DivK1c_006705

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
182.23 g/molcalc.
Exact mass
182.0844 Dacalc.
LogP (octanol/water)
3.02calc.
Topological polar surface area
28.68 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
0calc.
Heavy atoms
14calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.08calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)[nH]c1cnccc12

c1ccc2c(c1)[nH]c1cnccc12

3 rings, 13 atoms, the beta-Carboline ring system.

374 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
Precautionary statements (10)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Harman suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 48 suppliers
30 of 30 offers
  • 3WAY Pharm Inc
    China, ShanghaiUnclaimed profile
    HarmanGrade, purity and minimum order on request
    Price on request
    View
  • Aaron Chemicals LLC.
    China, NanjingUnclaimed profile
    HarmanGrade, purity and minimum order on request
    Price on request
    View
  • Abmole Bioscience Inc.
    United States, HoustonUnclaimed profile
    HarmanGrade, purity and minimum order on request
    Price on request
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  • Accel Scientific S.L.
    Spain, BarcelonaUnclaimed profile
    HarmanGrade, purity and minimum order on request
    Price on request
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  • Accela ChemBio Inc.
    United States, San DiegoUnclaimed profile
    HarmanGrade, purity and minimum order on request
    Price on request
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  • AChemBlock
    United States, HaywardUnclaimed profile
    HarmanGrade, purity and minimum order on request
    Price on request
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  • Achemtek
    United States, WoburnUnclaimed profile
    HarmanGrade, purity and minimum order on request
    Price on request
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  • Acmec Biochemical
    China, ShanghaiUnclaimed profile
    HarmanGrade, purity and minimum order on request
    Price on request
    View
  • AgroIntelBioScan.com
    Singapore, SingaporeUnclaimed profile
    HarmanGrade, purity and minimum order on request
    Price on request
    View
  • AiFChem
    United States, SomervilleUnclaimed profile
    HarmanGrade, purity and minimum order on request
    Price on request
    View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

48 suppliers in 10 countries

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Harman price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Mutagens
  • Neurotoxins

Roles

  • anti-HIV agent
  • antimicrobial agent
  • antiviral agent
  • enzyme inhibitor
  • eukaryotic metabolite
  • metabolite
  • plant metabolite

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Harman is traded under.

HS 2939.79Indicative HS code

Alkaloids of vegetal origin, other than cocaine, ecgonine, salts, esters and other derivatives, not elsewhere…

World exports in 2024
$701M
+18.9% vs 2023, imports $830M
2019 to 2024
Top exporters
  1. Switzerland * partner reported25.3%
  2. Germany21.4%
  3. India * partner reported14.9%
Top importers
  1. United States20.9%
  2. Germany14.7%
  3. Italy14.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Harman is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Harman, based on the data on this page

What is Harman?

Harman is an indole alkaloid fundamental parent with a structure of 9H-beta-carboline carrying a methyl substituent at C-1. It has been isolated from the bark of Sickingia rubra, Symplocus racemosa, Passiflora incarnata, Peganum harmala, Banisteriopsis caapi and Tribulus terrestris, as well as from tobacco smoke.

What is the CAS number of Harman?

The CAS registry number of Harman is 486-84-0. Other or deprecated CAS numbers: 1189461-56-0.

What is the molecular formula and weight of Harman?

The molecular formula of Harman is C12H10N2 and its molar mass is 182.23 g/mol.

What is Harman used for?

Known uses and roles of Harman include anti-hiv agent, antimicrobial agent, antiviral agent, enzyme inhibitor, eukaryotic metabolite and 4 more.

Is Harman hazardous?

Harman carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes skin irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Harman?

Harman is usually classified under HS code 293979 (Alkaloids, natural or reproduced by synthesis, and their salts, ethers, esters and other…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Harman?

CompoundList lists 48 suppliers of Harman in China, United States, United Kingdom, Hong Kong and 6 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Harman?

Suppliers quote Harman on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Harman

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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