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Impurities and reference standards

Hexamethyldisiloxane

Also known as Disiloxane, hexamethyl-, Oxybis(trimethylsilane), Fluka AG

CAS 107-46-0Formula C6H18OSi2Molar mass 162.38 g/molEC 203-492-7
GHS signal word: Danger. Pictograms: Flammable, Hazardous to the environment 68 suppliers listed
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Hexamethyldisiloxane chemical structure, C6H18OSi2, CAS 107-46-0
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Fluid
Melting point
-66 °C
Boiling point
99 °C
Density
0.7638 at 20 °C
Flash point
-30 °C
HS code
293190
Category
Impurities and reference standards
Illustrative photo, 200 litre steel drums of liquid in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Hexamethyldisiloxane?

Plain description, key identifiers and synonyms

Hexamethyldisiloxane is an organosiloxane consisting of two trimethylsilyl groups covalently bound to a central oxygen.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
trimethyl(trimethylsilyloxy)silane
CAS number
107-46-0 CAS number cross-checkedOther or deprecated CAS: 26298-61-3
EC number
203-492-7
Molecular formula
C6H18OSi2
UNII
D7M4659BPU
MDL number
MFCD00008265
INCI name
DIMETHICONE, DISILOXANE
InChIKey
UQEAIHBTYFGYIE-UHFFFAOYSA-N
InChI
InChI=1S/C6H18OSi2/c1-8(2,3)7-9(4,5)6/h1-6H3
SMILES (canonical and isomeric)
C[Si](C)(C)O[Si](C)(C)C

Synonyms

  • Disiloxane, hexamethyl-
  • Oxybis(trimethylsilane)
  • Fluka AG
  • Hexamethyl disiloxane
  • Bis(trimethylsilyl)ether
  • Belsil DM 0.65
  • Bis(trimethylsilyl)oxide
  • Bistrimethylsilyl ether
  • KF 96L
  • Silane, oxybis(trimethyl-
  • Dow corning 200
  • OS 10
  • Aec disiloxane
  • Mirasil hms
  • Volasil dm-0.65
  • SI-TEC DM 0.65
  • SF1000N-0.65 cSt
  • Xiameter PMX-200 Silicone Fluid 0.65 cSt
  • HMDSO
  • Bis(trimethylsilyl) ether
  • trimethyl(trimethylsilyloxy)silane
  • 1,1,1,3,3,3-Hexamethyldisiloxane
  • SWS-F 221
  • Bis(trimethylsilyl) oxide
  • Medetomidine Impurity 43
Show all 38 synonyms
  • trimethylsilyl ether
  • trimethyl[(trimethylsilyl)oxy]silane
  • Silane, oxybis(trimethyl)-
  • ((CH3)3Si)2O
  • Disiloxane, 1,1,1,3,3,3-hexamethyl-
  • Dimethicone ~4000 (Polydimethylsiloxane)
  • Bis-trimethylsilyl oxide
  • C6H18OSi2
  • Silcorel(R) adp1000 antifoam compound
  • bis-tms ether
  • di-tms ether
  • TMS ether
  • trimethylsilylether

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Fluidexp.
Melting point
-66 °Cexp.
Boiling point
99 °Cexp.
Density
0.7638 at 20 °Cexp.
Flash point
-30 °Cexp.
Solubility
In water, 0.93 mg/L at 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
162.38 g/molcalc.
Exact mass
162.0896 Dacalc.
LogP (octanol/water)
2.67calc.
Topological polar surface area
9.23 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
2calc.
Heavy atoms
9calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS02: Flammable
Flammable
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H225Highly flammable liquid and vapour.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
  • H411Toxic to aquatic life with long lasting effects.
Precautionary statements (13)
  • P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
  • P233Keep container tightly closed.
  • P240Ground and bond container and receiving equipment.
  • P241Use explosion-proof electrical, ventilating and lighting equipment.
  • P242Use non-sparking tools.
  • P243Take action to prevent static discharges.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P303 + P361 + P353If on skin (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower.
  • P370 + P378In case of fire: Use appropriate media to extinguish.
  • P391Collect spillage.
  • P403 + P235Store in a well-ventilated place. Keep cool.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Hexamethyldisiloxane suppliers

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Where suppliers are based

68 suppliers in 7 countries

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Hexamethyldisiloxane price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Hydraulic fluid (Organo Silicate MLO 5277).

Chemical intermediate for silicone fluids and elastomers.

Hexamethyldisiloxane is used in cosmetic and personal care products, in the production of octamethylcyclotetrasiloxane, as an adhesion promotor-priming agent for photolithography applications, and as an end blocking agent in the production of fluorosilicone oils.

/Used/ ... for headlights ... as a protective layer 20-30 nm thick ... effective diffusion barrier (condensed water resistance is 1000 times greater than without coating)... Other applications include the hydrophilic coating of contact lenses and the coating of medical materials to improve biocompatibility.

Used as antifoams in aqueous systems, in petroleum processing, and in laundry detergents ... In human and veterinary medicine ... used as antiflatulent agents ...

Read more

Useful as lubricants (eg, for films, yarn, medical articles, wine corks, and fillers). (Polydimethylsiloxanes).

Industrial uses: Other, Binder, Dispersing agent, Solvent, Insulators, Anti-adhesive/cohesive, Terminator/Blocker, Surface modifier.

Consumer uses: Diluent, Anti-static agent, Insulators, Solvent, Other.

Use classes: Cosmetics.

Cosmetic ingredient, INCI name DIMETHICONE(antifoaming, skin conditioning - emollient, skin conditioning, skin protecting)

Functional uses

  • Anti-stain agent
  • Chemical reaction regulator
  • Defoamer
  • Emulsifier
  • Film former
  • Humectant
  • Lubricating agent
  • Processing aids not otherwise specified
  • Softener and conditioner
  • Stabilizing agent
  • Surface modifier
  • Waterproofing agent

Cosmetic functions

  • Antifoaming
  • Skin conditioning
  • Skin conditioning - emollient
  • Skin conditioning - miscellaneous
  • Skin protecting

How it is made

Acid hydrolysis of chlorotrimethylsilane and purification by distillation.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Hexamethyldisiloxane is traded under.

HS 2931.90Indicative HS code

Organo-inorganic compounds, other than tetramethyl lead, tetraethyl lead, tributyltin compounds…

World exports in 2024
$3.97B
+5.3% vs 2023, imports $3.93B
2019 to 2024
Top exporters
  1. China28.3%
  2. United States15.6%
  3. Germany15.1%
Top importers
  1. United States14.6%
  2. China13.0%
  3. South Korea8.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Hexamethyldisiloxane is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Hexamethyldisiloxane, based on the data on this page

What is Hexamethyldisiloxane?

Hexamethyldisiloxane is an organosiloxane consisting of two trimethylsilyl groups covalently bound to a central oxygen.

What is the CAS number of Hexamethyldisiloxane?

The CAS registry number of Hexamethyldisiloxane is 107-46-0. Other or deprecated CAS numbers: 26298-61-3.

What is the molecular formula and weight of Hexamethyldisiloxane?

The molecular formula of Hexamethyldisiloxane is C6H18OSi2 and its molar mass is 162.38 g/mol.

What is Hexamethyldisiloxane used for?

Hydraulic fluid (Organo Silicate MLO 5277). Chemical intermediate for silicone fluids and elastomers.

Is Hexamethyldisiloxane hazardous?

Hexamethyldisiloxane carries the GHS signal word "Danger". Main hazards: highly flammable liquid and vapour, very toxic to aquatic life, very toxic to aquatic life with long lasting effects. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Hexamethyldisiloxane?

Hexamethyldisiloxane is usually classified under HS code 293190 (X. ORGANO-INORGANIC COMPOUNDS, HETEROCYCLIC COMPOUNDS, NUCLEIC ACIDS AND THEIR SALTS…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Hexamethyldisiloxane?

CompoundList lists 68 suppliers of Hexamethyldisiloxane in China, United States, India, Germany and 3 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Hexamethyldisiloxane in India?

4 suppliers in India list Hexamethyldisiloxane on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Hexamethyldisiloxane?

Suppliers quote Hexamethyldisiloxane on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Hexamethyldisiloxane

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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