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Impurities and reference standards

Icariin

Also known as Ieariline, Epimedii herba icariin, 3-((6-Deoxymannopyranosyl)oxy)-7-(glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one

CAS 489-32-7Formula C33H40O15Molar mass 676.67 g/molEC 610-440-0
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Icariin chemical structure, C33H40O15, CAS 489-32-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
489-32-7
Formula
C33H40O15
Molar mass
676.67 g/mol
EC number
610-440-0
HS code
293299
Category
Impurities and reference standards

What is Icariin?

Plain description, key identifiers and synonyms

Icariin is a member of the class of flavonols that is kaempferol which is substituted at position 8 by a 3-methylbut-2-en-1-yl group and in which the hydroxy groups at positions 3, 4', and 7 have been converted to the corresponding 6-deoxy-alpha-L-mannopyranoside, methyl ether, and beta-D-glucopyranoside, respectively. A phoshphodiesterase-5 inhibitor, it is obtained from several species of plants in the genus Epimedium and is thought to be the main active ingredient of the Chinese herbal medicine Herba Epimedii (yinyanghuo). It has a role as an antioxidant, a bone density conservation agent, an EC 3.1.4.35 (3',5'-cyclic-GMP phosphodiesterase) inhibitor and a phytoestrogen. It is a member of flavonols and a glycosyloxyflavone.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one
CAS number
489-32-7 CAS number cross-checked
EC number
610-440-0
Molecular formula
C33H40O15
UNII
VNM47R2QSQ
MDL number
MFCD00210516
InChIKey
TZJALUIVHRYQQB-XLRXWWTNSA-N
InChI
InChI=1S/C33H40O15/c1-13(2)5-10-17-19(45-33-28(42)26(40)23(37)20(12-34)46-33)11-18(35)21-24(38)31(48-32-27(41)25(39)22(36)14(3)44-32)29(47-30(17)21)15-6-8-16(43-4)9-7-15/h5-9,11,14,20,22-23,25-28,32-37,39-42H,10,12H2,1-4H3/t14-,20+,22-,23+,25+,26-,27+,28+,32-,33+/m0/s1
Canonical SMILES
COc1ccc(-c2oc3c(CC=C(C)C)c(OC4OC(CO)C(O)C(O)C4O)cc(O)c3c(=O)c2OC2OC(C)C(O)C(O)C2O)cc1
Isomeric SMILES
C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC2=C(OC3=C(C2=O)C(=CC(=C3CC=C(C)C)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O)C5=CC=C(C=C5)OC)O)O)O

Synonyms

  • Ieariline
  • Epimedii herba icariin
  • 3-((6-Deoxymannopyranosyl)oxy)-7-(glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
  • Icariine
  • Icarrin
  • Icariin (Standard)
  • 3-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-7-yl beta-D-glucopyranoside
  • Anhydroicaritin
  • Ieariline (Standard)
  • Horny goat weed extract
  • Icariin, analytical standard
  • Icariin, >=94% (HPLC)
  • Anhydroicaritin Impurity 6, Icariin
  • 3-[(6-Deoxy-alpha-L-mannopyranosyl)oxy]-7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
  • Sdccgmls-0066754.p001
  • 4H-1-Benzopyran-4-one, 3-((6-deoxy-alpha-L-mannopyranosyl)oxy)-7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-butenyl)-
  • 4'-Me ether, 3-O-alpha- L -rhamnopyranoside,
  • 4??-O-methyl-8-|?,|?-dimethylallylkaempferol-3-rhamnoside-7-glucoside
  • 3-[(6-Deoxy-?-L-mannopyranosyl)oxy]-7-?-D-glucopyranosyloxy-5-hydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
  • 3-[(6-Deoxy-alpha-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-1-benzopyran-7-yl beta-D-glucopyranoside
  • 4 inverted exclamation marka-O-methyl-8-|A,|A-dimethylallylkaempferol-3-rhamnoside-7-glucoside
  • 4H-1-Benzopyran-4-one, 3-((6-deoxy-alpha-l-mannopyranosyl)oxy)-7-(beta-d-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-
  • 5-Hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-7-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3-[(3,4,5-trihyd

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
676.67 g/molcalc.
Exact mass
676.2367 Dacalc.
LogP (octanol/water)
0.07calc.
Topological polar surface area
238.2 Ųcalc.
Hydrogen bond donors
8calc.
Hydrogen bond acceptors
15calc.
Rotatable bonds
9calc.
Heavy atoms
48calc.
Rings
5calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.49calc.
Formal charge
0calc.
Stereocentres
10calc.
Lipinski rule of five
Fails (3 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1c(OC2CCCCO2)c(-c2ccccc2)oc2cc(OC3CCCCO3)ccc12

O=c1c(OC2CCCCO2)c(-c2ccccc2)oc2cc(OC3CCCCO3)ccc12

5 rings, 31 atoms.

44 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Icariin suppliers

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Where suppliers are based

70 suppliers in 11 countries

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Icariin price

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Uses and applications

What the substance is used for, by industry and function

Roles

  • agonist
  • antioxidant
  • bone density conservation agent
  • enzyme inhibitor
  • estrogen
  • hormone
  • molecular messenger
  • pharmaceutical
  • phytoestrogen
  • sex hormone

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Icariin is traded under.

HS 2932.99Indicative HS code

Heterocyclic compounds with oxygen hetero-atom(s) only, other

World exports in 2024
$3.81B
+10.3% vs 2023, imports $7.05B
2019 to 2024
Top exporters
  1. China28.9%
  2. Switzerland * partner reported12.7%
  3. Germany7.8%
Top importers
  1. United States49.7%
  2. China11.9%
  3. India * partner reported3.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Icariin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Icariin, based on the data on this page

What is Icariin?

Icariin is a member of the class of flavonols that is kaempferol which is substituted at position 8 by a 3-methylbut-2-en-1-yl group and in which the hydroxy groups at positions 3, 4', and 7 have been converted to the corresponding 6-deoxy-alpha-L-mannopyranoside, methyl ether, and beta-D-glucopyranoside, respectively.

What is the CAS number of Icariin?

The CAS registry number of Icariin is 489-32-7.

What is the molecular formula and weight of Icariin?

The molecular formula of Icariin is C33H40O15 and its molar mass is 676.67 g/mol.

What is Icariin used for?

Known uses and roles of Icariin include agonist, antioxidant, bone density conservation agent, enzyme inhibitor, estrogen and 5 more.

Is Icariin hazardous?

No GHS hazard classification for Icariin is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Icariin?

Icariin is usually classified under HS code 293299 (Heterocyclic compounds with oxygen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Icariin?

CompoundList lists 70 suppliers of Icariin in China, United States, Germany, United Kingdom and 7 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Icariin in India?

1 supplier in India list Icariin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Icariin?

Suppliers quote Icariin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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