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Humectants

Isosorbide

Also known as Isobide, Devicoran, 1,4:3,6-Dianhydro-D-glucitol

CAS 652-67-5Formula C6H10O4Molar mass 146.14 g/molEC 211-492-3
87 suppliers listed Drug substance
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Isosorbide chemical structure, C6H10O4, CAS 652-67-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
652-67-5
Formula
C6H10O4
Appearance
Crystals
Melting point
61 to 64
HS code
294000
Category
Humectants
Illustrative photo, drums, an IBC tote and sacks in a chemical warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Isosorbide?

Plain description, key identifiers and synonyms

Isosorbide is an organic molecular entity.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(3S,3aR,6R,6aR)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3,6-diol
CAS number
652-67-5 CAS number cross-checkedOther or deprecated CAS: 28980-83-8
EC number
211-492-3
Molecular formula
C6H10O4
UNII
WXR179L51S
MDL number
MFCD00064827
INCI name
ISOSORBIDE
InChIKey
KLDXJTOLSGUMSJ-JGWLITMVSA-N
InChI
InChI=1S/C6H10O4/c7-3-1-9-6-4(8)2-10-5(3)6/h3-8H,1-2H2/t3-,4+,5-,6-/m1/s1
Canonical SMILES
OC1COC2C(O)COC12
Isomeric SMILES
C1[C@H]([C@@H]2[C@H](O1)[C@H](CO2)O)O

Synonyms

  • Isobide
  • Devicoran
  • 1,4:3,6-Dianhydro-D-glucitol
  • Hydronol
  • Ismotic
  • (3R,3aR,6S,6aR)-hexahydrofuro[3,2-b]furan-3,6-diol
  • (+)-D-Isosorbide
  • D-Glucitol, 1,4:3,6-dianhydro-
  • 1,4:3,6-Dianhydro-D-sorbitol
  • 1,4:3,6-Dianhydrosorbitol
  • Glucitol, 1,4:3,6-dianhydro-, D-
  • (3R,3aR,6S,6aR)-hexahydrofuro(3,2-b)furan-3,6-diol
  • GlyTouCan:G82967ZA
  • Sorbid
  • Vascardin dinitrate
  • 1,4-Dianhydrosorbitol
  • Dianhydro-D-glucitol
  • Isosorbida
  • (3S,3aR,6R,6aR)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3,6-diol
  • D-Isosorbide, Dianhydro-D-glucitol
  • Sorbitol, 1,4:3,6-dianhydro-
  • D-1,4:3,6-Dianhydroglucitol
  • Hydronol (VAN)
  • Isosorbidum
  • D-Isosorbide
Show all 34 synonyms
  • lsosorbide
  • Devicoran,
  • Hydronol,
  • Ismotic,
  • Sorbide (obsol.)
  • Ismotic (TN)
  • Isobide (TN)
  • Isobide. Isorgen G,
  • 1,6-Dianhydrosorbitol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystalsexp.
Melting point
61 to 64exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
146.14 g/molcalc.
Exact mass
146.0579 Dacalc.
LogP (octanol/water)
-1.49calc.
Topological polar surface area
58.92 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
0calc.
Heavy atoms
10calc.
Rings
2calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1CC2OCCC2O1

C1CC2OCCC2O1

2 rings, 8 atoms, the 1,4:3,6-Dianhydro-2,5-dideoxyhexitol ring system.

149 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Isosorbide suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 87 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

87 suppliers in 15 countries

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Isosorbide price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

Industrial uses: Lubricating agent.

Cosmetic ingredient, INCI name ISOSORBIDE(humectant, skin conditioning)

Pharmacological actions

  • Diuretics, Osmotic

Roles

  • antihypertensive agent
  • antineoplastic agent
  • cardiovascular drug
  • pharmaceutical

Functional uses

  • Humectant
  • Softener and conditioner

Cosmetic functions

  • Humectant
  • Skin conditioning

Pharmacology

Isosorbide is an organic nitrate with vasodilator activity. Isosorbide relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle. Elevated cGMP levels in smooth muscle activate cGMP-dependent kinase activity that leads to release of sequestered Ca2+. In turn, free Ca+ triggers dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition isosorbide relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area.

How it is made

Prepared by acid dehydration of d-glucitol: haworth, wiggins, british patent 600,870 (1948). Purification: hartmann, us patent 3,160,641 (1964 to atlas chem industries).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce, Regulatory flags: Added by a premanufacture notice

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Isosorbide is traded under.

HS 2940.00Indicative HS code

Sugar ethers, sugar acetals and sugar esters, and their salts, other than the products of heading 29.37…

World exports in 2024
$1.4B
−5.4% vs 2023, imports $1.42B
2019 to 2024
Top exporters
  1. Germany23.7%
  2. China20.6%
  3. United States11.5%
Top importers
  1. United States14.0%
  2. Japan7.4%
  3. Germany6.1%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Isosorbide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Isosorbide, based on the data on this page

What is Isosorbide?

Isosorbide is an organic molecular entity.

What is the CAS number of Isosorbide?

The CAS registry number of Isosorbide is 652-67-5. Other or deprecated CAS numbers: 28980-83-8.

What is the molecular formula and weight of Isosorbide?

The molecular formula of Isosorbide is C6H10O4 and its molar mass is 146.14 g/mol.

What is Isosorbide used for?

Veterinary medication:. Industrial uses: Lubricating agent.

Is Isosorbide hazardous?

No GHS hazard classification for Isosorbide is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Isosorbide?

Isosorbide is usually classified under HS code 294000 (Sugars, chemically pure, other than sucrose, lactose, maltose, glucose and fructose…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Isosorbide?

CompoundList lists 87 suppliers of Isosorbide in China, United States, India, United Kingdom and 11 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Isosorbide in India?

7 suppliers in India list Isosorbide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Isosorbide?

Suppliers quote Isosorbide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Isosorbide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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